Spatial code recognition in neuronal RNA targeting: Role of RNA–hnRNP A2 interactions

Muslimov, Ilham A.; Patel, Mihir V.; Rose, Arthur L.; Tiedge, Henri

doi:10.1083/jcb.201010027

Cited by 70 publications

(163 citation statements)

References 81 publications

(243 reference statements)

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“…The A2RE-dependent targeting of mRNAs is also involved in the dendritic delivery of Arc, CaMKIIa, and Neurogranin mRNAs, which appear to cluster in the same hnRNPA2-containing granules (Gao et al, 2008). Moreover, hnRNPA2 was also shown to be necessary for the delivery of the non-coding BC1 RNA and PKMz mRNA to distal dendritic domains (Muslimov et al, 2006(Muslimov et al, , 2011. (Cajigas et al, 2012;Lein et al, 2007;Poon et al, 2006;Zhong et al, 2006) was compared with the rat genes present in the Agilent Technologies Whole Rat Genome Microarray (https://earray.chem.agilent.com/ earray/catalogGeneLists.do?action¼displaylist#) using GOrilla.…”

Section: Cis-acting Elements and Mrna Transport Into Dendritesmentioning

confidence: 99%

“…The results focus on the classes of transcripts for which GO terms present a p-value lower than 10 À11 . Surprisingly, the interaction of the latter RNAs with hnRNPA2 depends on a non-canonical purine*purine interaction within BC1 and PKMz zipcodes, suggesting the existence of a spatial code mediating the targeting of these transcripts to dendrites by hnRNPA2 (Muslimov et al, 2011). In a recent study, the guanine (G)-quadruplex structures present in the 3 0 UTRs of CaMKIIa and PSD95 mRNAs were shown to direct these transcripts into dendrites (Subramanian et al, 2011).…”

Section: Cis-acting Elements and Mrna Transport Into Dendritesmentioning

confidence: 99%

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BDNF-induced local protein synthesis and synaptic plasticity

2014

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a b s t r a c tBrain-derived neurotrophic factor (BDNF) is an important regulator of synaptic transmission and longterm potentiation (LTP) in the hippocampus and in other brain regions, playing a role in the formation of certain forms of memory. The effects of BDNF in LTP are mediated by TrkB (tropomyosin-related kinase B) receptors, which are known to be coupled to the activation of the Ras/ERK, phosphatidylinositol 3-kinase/Akt and phospholipase C-g (PLC-g) pathways. The role of BDNF in LTP is best studied in the hippocampus, where the neurotrophin acts at pre-and post-synaptic levels. Recent studies have shown that BDNF regulates the transport of mRNAs along dendrites and their translation at the synapse, by modulating the initiation and elongation phases of protein synthesis, and by acting on specific miRNAs. Furthermore, the effect of BDNF on transcription regulation may further contribute to long-term changes in the synaptic proteome. In this review we discuss the recent progress in understanding the mechanisms contributing to the short-and long-term regulation of the synaptic proteome by BDNF, and the role in synaptic plasticity, which is likely to influence learning and memory formation.This article is part of the Special Issue entitled 'BDNF Regulation of Synaptic Structure, Function, and Plasticity'.

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Section: Cis-acting Elements and Mrna Transport Into Dendritesmentioning

confidence: 99%

Section: Cis-acting Elements and Mrna Transport Into Dendritesmentioning

confidence: 99%

BDNF-induced local protein synthesis and synaptic plasticity

2014

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“…Following their expression, BC200 RNAs immediately migrate to dendrites, where they interact and interfere with various translational initiation factors, including eIF4A, eIF4B, and PABP. [1][2][3][4][5][6][7] BC200 RNA is thought to exert local translational control by forming distinctive microdomains in dendrites, and this is believed to contribute to the maintenance of neuronal plasticity. BC1 RNA is the rodent counterpart of BC200 RNA 3 ; the 2 together comprise the BC RNAs.…”

Section: Introductionmentioning

confidence: 99%

Knockdown of BC200 RNA expression reduces cell migration and invasion by destabilizing mRNA for calcium-binding protein S100A11

et al. 2017

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Although BC200 RNA is best known as a neuron-specific non-coding RNA, it is overexpressed in various cancer cells. BC200 RNA was recently shown to contribute to metastasis in several cancer cell lines, but the underlying mechanism was not understood in detail. To examine this mechanism, we knocked down BC200 RNA in cancer cells, which overexpress the RNA, and examined cell motility, profiling of ribosome footprints, and the correlation between cell motility changes and genes exhibiting altered ribosome profiles. We found that BC200 RNA knockdown reduced cell migration and invasion, suggesting that BC200 RNA promotes cell motility. Our ribosome profiling analysis identified 29 genes whose ribosomal occupations were altered more than 2-fold by BC200 RNA knockdown. Many (> 30%) of them were directly or indirectly related to cancer progression. Among them, we focused on S100A11 (which showed a reduced ribosome footprint) because its expression was previously shown to increase cellular motility. S100A11 was decreased at both the mRNA and protein levels following knockdown of BC200 RNA. An actinomycin-chase experiment showed that BC200 RNA knockdown significantly decreased the stability of the S100A11 mRNA without changing its transcription rate, suggesting that the downregulation of S100A11 was mainly caused by destabilization of its mRNA. Finally, we showed that the BC200 RNAknockdown-induced decrease in cell motility was mainly mediated by S100A11. Together, our results show that BC200 RNA promotes cell motility by stabilizing S100A11 transcripts.

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“…HnRNPs have also been demonstrated to be essential for RNA localization in many organisms (St Johnston, 2005;Lewis and Mowry, 2007). Some notable examples are the transport of RNAs to the distal dentritic domain (Muslimov et al, 2011) by hnRNP A2 and the transport of myelin basic protein in oligodendrocytes by hnRNP A3 (Ma et al, 2002). Hence, it is likely that the identified rice hnRNPs play an important role in the movement of prolamine mRNAs (Crofts et al, 2010).…”

mentioning

confidence: 99%

Multiple RNA Binding Protein Complexes Interact with the Rice Prolamine RNA Cis-Localization Zipcode Sequences

Yang

Crofts

et al. 2014

Plant Physiol.

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RNAs for the storage proteins, glutelins and prolamines, contain zipcode sequences, which target them to specific subdomains of the cortical endoplasmic reticulum in developing rice (Oryza sativa) seeds. Fifteen RNA binding proteins (RBPs) specifically bind to the prolamine zipcode sequences and are likely to play an important role in the transport and localization of this storage protein RNA. To understand the underlying basis for the binding of multiple protein species to the prolamine zipcode sequences, the relationship of five of these RBPs, RBP-A, RBP-I, RBP-J, RBP-K, and RBP-Q, were studied. These five RBPs, which belong to the heterogeneous nuclear ribonucleoprotein class, bind specifically to the 59 coding regions as well as to the 39 untranslated region zipcode RNAs but not to a control RNA sequence. Coimmunoprecipitation-immunoblot analyses in the presence or absence of ribonuclease showed that these five RBPs are assembled into three multiprotein complexes to form at least two zipcode RNA-protein assemblies. One cytoplasmic-localized zipcode assembly contained two multiprotein complexes sharing a common core consisting of RBP-J and RBP-K and either RBP-A (A-J-K) or RBP-I (I-J-K). A second zipcode assembly of possibly nuclear origin consists of a multiprotein complex containing RBP-Q and modified forms of the other protein complexes. These results suggest that prolamine RNA transport is initiated in the nucleus to form a zipcode-protein assembly, which is remodeled in the cytoplasm to target the RNA to its proper location on the cortical endoplasmic reticulum.

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Spatial code recognition in neuronal RNA targeting: Role of RNA–hnRNP A2 interactions

Abstract: Recognition of non-canonical purine•purine RNA motifs by hnRNP A2 mediates targeted delivery of neuronal RNAs to dendrites.

Cited by 70 publications

References 81 publications

BDNF-induced local protein synthesis and synaptic plasticity

BDNF-induced local protein synthesis and synaptic plasticity

Knockdown of BC200 RNA expression reduces cell migration and invasion by destabilizing mRNA for calcium-binding protein S100A11

Multiple RNA Binding Protein Complexes Interact with the Rice Prolamine RNA Cis-Localization Zipcode Sequences

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