Spatial and Frequency-specific Electrophysiological Signatures of Tonic Pain Recovery in Humans

Rustamov, Nabi; Sharma, Lokesh; Chiang, Sarah N; Burk, Carrie; Haroutounian, Simon; Leuthardt, Eric C.

doi:10.1016/j.neuroscience.2021.04.008

Cited by 11 publications

(23 citation statements)

References 93 publications

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“…Baseline EEG data were collected for 10 minutes. Then, thermostat-controlled circulating cold-water bath was used to induce moderate pain (see Ref. 58 for the cold-pressor test procedure).…”

Section: Methodsmentioning

confidence: 99%

“…The raw EEG data were preprocessed in MATLAB environment (Mathworks, Natick, MA; see Refs. 56 57 58 for the EEG data processing pipeline). Frequency bands were specified in the following manner: 1 to 3 Hz: delta; 4 to 7 Hz: theta; 8 to 13 Hz: alpha; 14 to 29 Hz: beta; 30 to 58 Hz: low gamma; 62 to 100 Hz: high gamma.…”

Section: Methodsmentioning

confidence: 99%

“…The power spectral density (PSD) was computed for all the conditions using Welch method 73 as described previously (see Refs. 56 and 58 for a data processing pipeline). The power spectrum from 1 to 100 Hz was obtained.…”

Section: Methodsmentioning

confidence: 99%

“… 8 Additionally, our previous work has shown the association between recovery from acute thermally induced pain and prefrontal theta power rebound. 58 Although experimental tonic pain is thought to closely simulate the subjective properties of clinical chronic pain because its high level of unpleasantness, 28 , 44 , 45 , 55 those results cannot be necessarily extrapolated to chronic pain relief. Although tonic pain has only been explored with painful thermal tests that last minutes, chronic pain in the clinical practice is not restricted to a single etiology and occurs over much longer periods.…”

Section: Introductionmentioning

confidence: 99%

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Relief of chronic pain associated with increase in midline frontal theta power

Rustamov

Wilson

Fogarty

et al. 2022

PR9

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Introduction: There is a need to identify objective cortical electrophysiological correlates for pain relief that could potentially contribute to a better pain management. However, the field of developing brain biomarkers for pain relief is still largely underexplored. Objectives: The objective of this study was to investigate cortical electrophysiological correlates associated with relief from chronic pain. Those features of pain relief could serve as potential targets for novel therapeutic interventions to treat pain. Methods: In 12 patients with chronic pain in the upper or lower extremity undergoing a clinically indicated nerve block procedure, brain activity was recorded by means of electroencephalogram before and 30 minutes after the nerve block procedure. To determine the specific cortical electrophysiological correlates of relief from chronic pain, 12 healthy participants undergoing cold-pressor test to induce experimental acute pain were used as a control group. The data were analyzed to characterize power spectral density patterns of pain relief and identify their source generators at cortical level. Results: Chronic pain relief was associated with significant delta, theta, and alpha power increase at the frontal area. However, only midfrontal theta power increase showed significant positive correlation with magnitude of reduction in pain intensity. The sources of theta power rebound were located in the left dorsolateral prefrontal cortex (DLPFC) and midline frontal cortex. Furthermore, theta power increase in the midline frontal cortex was significantly higher with chronic vs acute pain relief. Conclusion: These findings may provide basis for targeting chronic pain relief via modulation of the midline frontal theta oscillations.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Relief of chronic pain associated with increase in midline frontal theta power

Rustamov

Wilson

Fogarty

et al. 2022

PR9

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“… 76–78 However, scalp EEG was found to effectively record high gamma activity up to 100 Hz. 48 , 79–83 On the other hand, notch filtering (60 Hz) can possibly affect cortical oscillations at the neighbouring frequencies. That is why broadband gamma 84 was defined between 65 and 00 Hz.…”

Section: Methodsmentioning

confidence: 99%

Theta–gamma coupling as a cortical biomarker of brain–computer interface-mediated motor recovery in chronic stroke

Rustamov

Humphries

Carter

et al. 2022

Brain Communications

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Chronic stroke patients with upper limb motor disabilities are now beginning to see treatment options that were not previously available. To date, the two options recently approved by the United States Food and Drug Administration include vagus nerve stimulation and brain-computer interface therapy. While the mechanisms for vagus nerve stimulation have been well defined, the mechanisms underlying brain-computer interface-driven motor rehabilitation are largely unknown. Given that cross-frequency coupling has been associated with a wide variety of higher-order functions involved in learning and memory, we hypothesized this rhythm specific mechanism would correlate with the functional improvements effected by a brain-computer interface. This study investigated whether the motor improvements in chronic stroke patients induced with a brain-computer interface therapy is associated with alterations in phase-amplitude coupling, a type of cross-frequency coupling. Seventeen chronic hemiparetic stroke patients used a robotic hand orthosis controlled with contralesional motor cortical signals measured with EEG. Patients regularly performed a therapeutic brain-computer interface task for 12 weeks. Resting state EEG recordings and motor function data were acquired before initiating brain-computer interface therapy and once every four weeks after the therapy. Changes in phase-amplitude coupling values were assessed and correlated with motor function improvements. To establish whether coupling between two different frequency bands was more functionally important than either of those rhythms alone, we calculated power spectra as well. We found that theta-gamma coupling was enhanced bilaterally at the motor areas and showed significant correlations across brain-computer interface therapy sessions. Importantly, increase in theta-gamma coupling positively correlated with motor recovery over the course of rehabilitation. The sources of theta-gamma coupling increase following brain-computer interface therapy were mostly located in the hand regions of primary motor cortex on the left and right cerebral hemispheres. Beta-gamma coupling decreased bilaterally at the frontal areas following the therapy, but these effects did not correlate with motor recovery. Alpha-gamma coupling was not altered by brain-computer interface therapy. Power spectra did not change significantly over the course of the brain-computer interface therapy. The significant functional improvement in chronic stroke patients induced by brain-computer interface therapy was strongly correlated with increased theta-gamma coupling in bihemispheric motor regions. These findings support the notion that specific cross frequency coupling dynamics in the brain likely play a mechanistic role in mediating motor recovery in the chronic phase of stroke recovery.

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Modulation of pain perception through transcranial alternating current stimulation and its nonlinear relationship with the simulated electric field magnitude

Ikarashi,

Otsuru,

Gomez‐Tames

et al. 2024

European Journal of Pain

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BackgroundOscillatory activities observed in multiple regions are closely associated with the experience of pain. Specifically, oscillatory activities within the theta‐ and beta‐frequency bands, observed in the left dorsolateral prefrontal cortex (DLPFC), have been implicated in pain perception among healthy individuals and those with chronic pain. However, their physiological significance remains unclear.MethodsWe explored the modulation of pain perception in healthy individuals by theta‐ and beta‐band transcranial alternating current stimulation (tACS) over the left DLPFC and examined the relationship between the modulation effect and magnitude of the electric field elicited by tACS in the left DLPFC using computational simulation.ResultsOur findings revealed that both theta‐ and beta‐tACS increased the heat pain threshold during and after stimulation. Notably, the simulated electric field magnitude in the left DLPFC exhibited an inverted U‐shaped relationship with the pain modulation effect for theta‐tACS.ConclusionsOur study findings suggested that there would be an optimal electric field strength to produce a high analgesic effect for theta‐tACS.SignificanceThe application of theta‐ and beta‐tACS interventions targeting the left DLPFC might facilitate the treatment of chronic pain. Furthermore, the attainment of effective pain modulation via theta‐tACS over the DLPFC warrants the use of optimal stimulus intensity.

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Spatial and Frequency-specific Electrophysiological Signatures of Tonic Pain Recovery in Humans

Cited by 11 publications

References 93 publications

Relief of chronic pain associated with increase in midline frontal theta power

Relief of chronic pain associated with increase in midline frontal theta power

Theta–gamma coupling as a cortical biomarker of brain–computer interface-mediated motor recovery in chronic stroke

Modulation of pain perception through transcranial alternating current stimulation and its nonlinear relationship with the simulated electric field magnitude

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