Spatholobus suberectus inhibits cancer cell growth by inducing apoptosis and arresting cell cycle at G2/M checkpoint

Wang, Zhi Yu; Wang, Dong Mei; Loo, Tjing Yung; Cheng, Yufeng; Chen, Lei Lei; Jia-heng, Shen; Yang, De; Chow, Louis W.C.; Guan, Xin Yuan; Chen, Jianping

doi:10.1016/j.jep.2010.11.004

Cited by 49 publications

(49 citation statements)

References 28 publications

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“…Chemotherapy is one of the major treatment strategies to eliminate residual cancer cells and prevent metastasis after surgery or radiotherapy (18). Chemotherapeutic efficacy or therapeutic index is contingent upon differences during sensitivity between tumor and normal tissue.…”

Section: Discussionmentioning

confidence: 99%

Selective cell cycle arrest and induction of apoptosis in human prostate cancer cells by a polyphenol-rich extract of Solanum nigrum

et al. 2011

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Progression of prostate cancer is associated with escape of tumor cells from cell cycle arrest and apoptosis. Agents capable of selectively eliminating cancer cells by cell cycle arrest and/or induction of apoptosis offer a highly desirable approach. Here we demonstrate that a polyphenolic extract derived from ripe berries of Solanum nigrum (SN) differentially causes cell cycle arrest and apoptosis in various human prostate cancer cells without affecting normal prostate epithelial cells. Virally transformed normal human prostate epithelial PZ-HPV-7 cells and their cancer counterpart CA-HPV-10 cells, were used to evaluate the growth-inhibitory effects of the SN extract. SN treatment (5–20 μg/ml) of PZ-HPV-7 cells resulted in growth inhibitory responses of low magnitude. In sharp contrast, SN treatment of CA-HPV-10 cells increased cytotoxicity, decreased cell viability and induced apoptosis. Similar results were noted in the human prostate cancer LNCaP, 22Rv1, DU145 and PC-3 cell lines, where significant reductions in cell viability and induction of apoptosis was observed in all these cells, an effect independent of disease stage and androgen association. Cell cycle analysis revealed that SN treatment (5–20 μg/ml) resulted in a dose-dependent G2/M phase arrest and subG1 accumulation in the CA-HPV-10 but not in the PZ-HPV-7 cell line. Our results, for the first time, demonstrate that the SN extract is capable of selectively inhibiting cellular proliferation and accelerating apoptotic events in prostate cancer cells. SN may be developed as a promising therapeutic and/or preventive agent against prostate cancer.

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Section: Discussionmentioning

confidence: 99%

Selective cell cycle arrest and induction of apoptosis in human prostate cancer cells by a polyphenol-rich extract of Solanum nigrum

et al. 2011

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“…Mucuna birdwoodiana Tutcher has shown inhibitory eŠects on prostaglandin biosynthesis (42). Spatholobus suberectus Stem has been shown to inhibit tumor cell growth (breast and colon cancer cell lines) through apoptosis induction (43). Some iso‰avones are isolated from Millettia reticulata Benth and Spatholobus suberectus Stem, and genistein has been identiˆed from both species (40,44).…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Antimutagenic Effects of Aqueous Extracts from Herbal Medicines against N-Alkyl-N-nitrosoureas-induced Mutagenicity Using the umu Test

Inami

Takada

Itoh

et al. 2014

Genes and Environment

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“…Phytochemicals that function as cell-cycle modulators are gaining widespread attention due to the recent evidence of concomitant involvement of apoptosis and cell cycle inhibition (Ding et al, 2011;Wang et al, 2011). In many instances, irregularities in cell cycle regulation are associated with cancer progression (Park and Lee, 2003).…”

Section: Discussionmentioning

confidence: 99%

Dentatin isolated from Clausena excavata induces apoptosis in MCF-7 cells through the intrinsic pathway with involvement of NF-κB signalling and G0/G1 cell cycle arrest: A bioassay-guided approach

Arbab

Abdul

Sukari

et al. 2013

Journal of Ethnopharmacology

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Spatholobus suberectus inhibits cancer cell growth by inducing apoptosis and arresting cell cycle at G2/M checkpoint

Cited by 49 publications

References 28 publications

Selective cell cycle arrest and induction of apoptosis in human prostate cancer cells by a polyphenol-rich extract of Solanum nigrum

Selective cell cycle arrest and induction of apoptosis in human prostate cancer cells by a polyphenol-rich extract of Solanum nigrum

Assessment of the Antimutagenic Effects of Aqueous Extracts from Herbal Medicines against N-Alkyl-N-nitrosoureas-induced Mutagenicity Using the umu Test

Dentatin isolated from Clausena excavata induces apoptosis in MCF-7 cells through the intrinsic pathway with involvement of NF-κB signalling and G0/G1 cell cycle arrest: A bioassay-guided approach

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