Spasticity Management in Multiple Sclerosis

Hughes, Christina; Howard, Ileana M.

doi:10.1016/j.pmr.2013.07.003

Cited by 37 publications

(22 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…If ED is found with baclofen use, a lower dosage or discontinuation of the medication has been found to reverse the adverse effect 82. While baclofen is a first-line drug for spasticity, there are other options that may have more favourable adverse side effects for the individual patient 83. These alternatives include tizanidine, an alpha-2-agonist that reduces spasticity by inhibiting the presynaptic motor neurons83; and dantrolene, which inhibits the release of calcium from the sarcoplasmic reticulum in skeletal muscles 83.…”

Section: Muscle Relaxantsmentioning

confidence: 99%

“…While baclofen is a first-line drug for spasticity, there are other options that may have more favourable adverse side effects for the individual patient 83. These alternatives include tizanidine, an alpha-2-agonist that reduces spasticity by inhibiting the presynaptic motor neurons83; and dantrolene, which inhibits the release of calcium from the sarcoplasmic reticulum in skeletal muscles 83. Other alternatives to baclofen, such as gabapentin and benzodiazepines, have also been associated with sexual dysfunction and are not recommended if ED is experienced with baclofen 84 85…”

Section: Muscle Relaxantsmentioning

confidence: 99%

See 1 more Smart Citation

Effect of prescription medications on erectile dysfunction

Razdan

Patel

Alameddine

et al. 2017

Postgraduate Medical Journal

View full text Add to dashboard Cite

Erectile dysfunction (ED) affects about 50% of men in the USA and is primarily attributed to physiological (organic) and psychological causes. However, a substantial portion of men suffer from ED due to iatrogenic causes. Common medications such as antihypertensives, non-steroidal anti-inflammatory drugs and antacids may cause ED. Physicians should be aware of the various prescription medications that may cause ED to properly screen and counsel patients on an issue that many may feel too uncomfortable to discuss. In this review, we discuss the physiology, data and alternative therapies for the ED caused by medications.

show abstract

Section: Muscle Relaxantsmentioning

confidence: 99%

Section: Muscle Relaxantsmentioning

confidence: 99%

Effect of prescription medications on erectile dysfunction

Razdan

Patel

Alameddine

et al. 2017

Postgraduate Medical Journal

View full text Add to dashboard Cite

show abstract

“…In addition to trigger avoidance, treatment options for MS spasticity involve physiotherapy and/or oral antispasticity medications such as baclofen, tizanidine, benzodiazepines, dantrolene and gabapentin [8,9,11]. However, many patients fail to respond adequately to these classical medications at tolerable doses or they become resistant to treatment.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness and Tolerability of THC/CBD Oromucosal Spray for Multiple Sclerosis Spasticity in Italy: First Data from a Large Observational Study

Trojano¹,

Vila²

2015

Eur Neurol

View full text Add to dashboard Cite

Background: The prospective, non-interventional Mobility Improvement (MOVE) 2 study was designed to provide real life data on clinical outcomes of patients with treatment-resistant multiple sclerosis (MS) spasticity receiving routine treatment with tetrahydrocannabinol (THC):cannabidiol (CBD) oromucosal spray (Sativex®), subsequent to its approval in European countries. Methods: This interim analysis reports on MOVE 2 patients from Italy. Results: Interim data from 322 patients (58.3% female; mean age 51.1 ± 10.2 years) were analyzed. From baseline to month 3 of treatment (Visit 3), the mean 0-10 Numerical Rating Scale (NRS) score decreased by -19.1% (-1.6 points, p < 0.0001) and the mean modified Ashworth score decreased from 2.6 to 2.3 points (p < 0.0001). At Visit 3, 24.6% of 203 patients with available data were clinically relevant responders (≥30% improvement from baseline NRS score; p < 0.001 vs. baseline). The mean reported dose of THC:CBD oromucosal spray was 6.1 ± 2.5 sprays/day at Visit 1 (1 month) and 5.1 ± 2.6 sprays/day at Visit 3 (range 1-12 sprays/day at both timepoints). Forty-one (13.1%) patients reported at least one adverse event (AE), which included 3 serious AEs (1 unrelated). AEs with an incidence ≥1% were dizziness (5.6%), confusion (2.5%), nausea (1.25%) and somnolence (1.25%). Conclusion: In everyday clinical practice in Italy, THC:CBD oromucosal spray provided symptomatic relief of MS spasticity with good tolerability in a relevant number of previously resistant patients.

show abstract

“…In response to the often-prohibitive costs of medications and the adverse side effects that may accompany certain drugs, patients with MS often use complementary and alternative treatments as methods of disease management. It is estimated that between 54 and 57% of patients in the United States with MS use some form of complementary or alternative treatment, and prevalence of these therapies may be even higher in other countries such as Great Britain (Hughes and Howard, 2013 ). Complementary and alternative medicine (CAM) includes a wide range of non-pharmacological interventions that are defined by the National Center for Complementary and Alternative Medicine (NCCAM) as “complementary” when used in addition to conventional medicine and “alternative” when used in place of it.…”

Section: Introductionmentioning

confidence: 99%

Yoga as a method of symptom management in multiple sclerosis

Frank

Larimore

2015

Front. Neurosci.

View full text Add to dashboard Cite

Multiple Sclerosis (MS) is an immune-mediated process in which the body's immune system damages myelin in the central nervous system (CNS). The onset of this disorder typically occurs in young adults, and it is more common among women. Currently, there is no cure and the long-term disease progression makes symptomatic management critical for maintaining quality of life. Several pharmacotherapeutic agents are approved for treatment, but many patients seek complementary and alternative interventions. Reviews have been conducted regarding broad topics such as mindfulness-based interventions for people diagnosed with MS and the impact of yoga on a range of neurological disorders. The objective of the present review is to examine the potential benefits of yoga for individuals with MS and address its use in managing symptoms including pain, mental health, fatigue, spasticity, balance, bladder control, and sexual function.

show abstract

Spasticity Management in Multiple Sclerosis

Cited by 37 publications

References 28 publications

Effect of prescription medications on erectile dysfunction

Effect of prescription medications on erectile dysfunction

Effectiveness and Tolerability of THC/CBD Oromucosal Spray for Multiple Sclerosis Spasticity in Italy: First Data from a Large Observational Study

Yoga as a method of symptom management in multiple sclerosis

Contact Info

Product

Resources

About