Spasmolytic Constituents of Cedrus deodara (Roxb.) Loud: Pharmacological Evaluation of Himachalol

In vitro screening of medicinal plant extracts for macrofilaricidal activity

“…R. communis has central nervous system (CNS) stimulant (Ferraz et al 1999), antitumor (Lin and Liu 1986), antifertility (Makonnen et al 1999), antifilarial (Titanji et al 1987), antiparasitic (Jacobson and Schlein 1999) and insecticidal (Alvarez Montes de Oca et al 1996) properties. C. deodara is known as an antioxidant (Tiwari et al 2001), anti-inflammatory, analgesic, immunomodulatory (Shinde et al 1999a,b) and a spasmolytic (Kar et al 1975). This study has revealed the macrofilaricidal properties of S. indicus and C. deodara that are known for other medicinal properties as mentioned above.…”

Effect of Cedrus deodara (Pinaceae) Root Oil on the Histopathology of Rat Liver and Kidney

“…Prominent morphological and pathological changes were also found in kidney tissues (Figure 2). One of the important compounds, himachalol, in the wood of C. deodara has been reported to exert antispasmodic activity on tissues such as the ileum, jejunum and bronchial muscles of guinea pigs and rabbits [3].…”

“…In the frontier province (N.W.F.P) of Pakistan, the root oil is used as an anti-ulcer drug by Hakims (old Unic-medical personals). There is a report that one of the major component in the wood of Cedrus deodara, himachalol, has antispasmodic and spasmolytic activities similar to those of paparverine that also induces spasm in different tissues such as ileum, jejunum and bronchial muscles when given in different doses [3]. Another study reported the use of wood essential oil of Cedrus deodara, as a 15% dispersion in castor oil, as a dermal application in rabbit for the treatment of skin diseases [4].…”

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“…Intravenous injection of himachalol (3-10 mg/kg) in the cat produced a dose-dependent fall in blood pressure and an increased femoral blood flow. [22]  Anti-secretory and anti-ulcer activities: The volatile oil extracted by steam distillation of C. deodara wood was examined for its gastric anti-secretory and antiulcer effect in the pylorus-ligated rat model and ethanol induced gastric lesions in rats. It was reported that volatile oil showed significant antisecretory activity as evidenced by decreased gastric fluid volume, total acidity, free acidity and increase in the pH of the gastric fluid in pylorus-ligated rats and this study revealed that pretreatment with…”

“…[20] Chemical constituents: The principle constituents of the oil are sesquiterpene i.e., α-himachalene (12.5%) and β-himachalene (43%) [21] associated with them are sesquiterpene alcohols (himachalol, allohimachalol, himadarol, isocentdarol and centdarol. [22] Through spectroscopic analysis (Figure 2), some compounds were isolated from the pine needles of cedrus deodara are identified as 9-hydroxy-dodecanoic acid , ethyl laurate , ethyl stearate , 3-beta-hydroxy-oleanolic acid methyl ester , beta-sitosterol , shikimic acid , methyl coniferin , ferulic acid, beta-glucoside.…”