Spasmolytic Constituents from <i>Eucalyptus camaldulensis </i>var. <i>obtusa</i> Leaves

Begum, Sabira; Farhat,; Sultana, Ishrat; Siddiqui, Bina Shaheen; Shaheen, Farzana; Gilani, Anwarul Hassan

doi:10.1021/np9902340

Cited by 27 publications

(21 citation statements)

References 25 publications

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“…Hence 29 may be regarded as the biogenetic precursor of 1. Compounds 29 and 29a were found inactive at 1 mg/mL, while 29b was moderately active in showing spasmolytic activity [29].…”

Section: Oleanolic Acid As a Trypanocidal Constituent In Rosemarymentioning

confidence: 96%

Oleanolic acid and related derivatives as medicinally important compounds

Sultana

Ata

2008

Journal of Enzyme Inhibition and Medicinal Chemistry

182

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Oleanolic acid has been isolated from chloroform extract of Olea ferruginea Royle after removal of organic bases and free acids. The literature survey revealed it to be biologically very important. In this review the biological significance of oleanolic acid and its derivatives has been discussed. The aim of this review is to update current knowledge on oleanolic acid and its natural and semisynthetic analogs, focussing on its cytotoxic, antitumer, antioxidant, anti-inflamatory, anti-HIV, acetyl cholinesterase, alpha-glucosidase, antimicrobial, hepatoprotective, anti-inflammatory, antipruritic, spasmolytic activity, anti-angiogenic, antiallergic, antiviral and immunomodulatory activities. We present in this review, for the first time, a compilation of the most relevant scientific papers and technical reports of the chemical, pre-clinical and clinical research on the properties of oleanolic acid and its derivatives.

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“…Hence 29 may be regarded as the biogenetic precursor of 1. Compounds 29 and 29a were found inactive at 1 mg/mL, while 29b was moderately active in showing spasmolytic activity [29].…”

Section: Oleanolic Acid As a Trypanocidal Constituent In Rosemarymentioning

confidence: 96%

Oleanolic acid and related derivatives as medicinally important compounds

Sultana

Ata

2008

Journal of Enzyme Inhibition and Medicinal Chemistry

182

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“…The triterpenoid camaldulin (3β-formyloxyurs-11-en-28,13β-olide), ursolic acid lactone acetate and ursolic acid lactone isolated from Eucalyptus camaldulensis var. obtuse, showed spasmolytic activity and possessed calcium antagonist activity [101].…”

Section: Gastrointestinal Effectsmentioning

confidence: 99%

“…Its structure has been established as 3β-hydroxyolean-9(11),12-dien-28-oic acid [100].A new triterpenoid camaldulin (3β-formyloxyurs-11-en-28,13β-olide) along with ursolic acid lactone acetate, ursolic acid lactone, betulinic acid and β-sitosterol 3-O-β-d-glucopyranoside were isolated from Eucalyptus camaldulensis var. obtuse leaves [101]. Triterpenoid amirinic acid (2alpha,3beta,7beta-trihydroxy11alpha-methoxyurs -12-en-28-oic acid and 2alpha, 3beta, 7beta-trihydroxyurs-11-en-28,13beta -olide), ursolic acid lactone, betulinic acid, oleanolic acid and ursolic acid, were isolated from fresh, uncrushed leaves of Ecalyptus camaldulensis var.…”

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confidence: 99%

The pharmacological and therapeutic importance of Eucalyptus species grown in Iraq

Al-Snafi¹

2017

IOSRPHR

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Abstract:-Eucalyptus species grown in Iraq were included Eucalyptus bicolor (Syn: Eucalyptus largiflorens), Eucalyptus griffithsii, Eucalyptus camaldulensis (Syn: Eucalyptus rostrata) Eucalyptus incrassate, Eucalyptus torquata and Eucalyptus microtheca (Syn: Eucalyptus coolabahs). Eucalypts contained volatile oils which occurred in many parts of the plant, depending on the species, but in the leaves that oils were most plentiful. The main constituent of the volatile oil derived from fresh leaves of Eucalyptus species was 1,8-cineole. The reported content of 1,8-cineole varies for 54-95%. The most common constituents co-occurring with 1,8-cineole were limonene, α-terpineol, monoterpenes, sesquiterpenes, globulol and α , β and ϒ-eudesmol, and aromatic constituents. The pharmacological studies revealed that Eucalypts possessed gastrointestinal, antiinflammatory, analgesic, antidiabetic, antioxidant, anticancer, antimicrobial, antiparasitic, insecticidal, repellent, oral and dental, dermatological, nasal and many other effects. The current review highlights the chemical constituents and pharmacological and therapeutic activities of Eucalyptus species grown in Iraq.

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“…The 70% aqueous-ethanol extracts of fruits and leaves of M. citrifolia showed relaxant effect on isolated spontaneously contracting rabbit jejunum preparation at a dose range of 0.3-5.0 mg/ml and 0.1-3.0 mg/ml respectively according to the procedure reported earlier [12].…”

Section: Spasmolytic and Spasmogenic Activitiesmentioning

confidence: 99%