Spasmolytic activity of lapachol and its derivatives, α and β-lapachone, on the guinea-pig ileum involves blockade of voltage-gated calcium channels

Cavalcante, Fabiana de Andrade; Silva, Joelmir Lucena Veiga da; Carvalho, Viviane M. N.; Camara, Celso de Amorim; Silva, Tânia Maria Sarmento da; Pinto, Ângelo C.; Vargas, Maria D.; Silva, Bagnólia A.

doi:10.1590/s0102-695x2008000200007

Cited by 8 publications

(3 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lapachol, α-lapachone and β-lapachone are the most highly concentrated compounds of the naturally occurring naphthoquinones in Tabebuia spp (Cavalcante et al, 2008). Lapachol is an easily extracted prenylated naphthoquinone and represents about 3 to 7% of the total chemical constituents of the plant, depending on the species (Aucélio et al, 2013;.…”

Section: Naphthoquinones and The Tabebuia Genusmentioning

confidence: 99%

Anti-inflammatory and cicatrizing properties of the Tabebuia genus: A review

Brito

Pereira

Silva

et al. 2021

RSD

View full text Add to dashboard Cite

The Tabebuia genus is one of the largest genera of the Bignoniaceae family, comprising more than 100 species. One of its main representatives is the ipê tree, which is popularly known for their ornamental and logging potential. However, parts of the tree, such as the stem, leaves and flowers, are used in traditional medicine for anti-bacterial, anti-inflammatory (rhinitis, sinusitis, tonsillitis and pharyngitis), anti-ulcerogenic, antiviral, antineoplastic, antimalarial and immunomodulatory purposes. The objective of the present study was to collate articles on the cicatrizing and therapeutic properties of species belonging to the Tabebuia spp genus.

show abstract

Section: Naphthoquinones and The Tabebuia Genusmentioning

confidence: 99%

Anti-inflammatory and cicatrizing properties of the Tabebuia genus: A review

Brito

Pereira

Silva

et al. 2021

RSD

View full text Add to dashboard Cite

show abstract

“…Beta-lapachone was synthesized from naturally occurring lapachol derived from T. avellanedae (Bignoneaceae) using sulfuric acid according to a method from Cavalcante et al (11).…”

Section: Synthesis Of Beta-lapachonementioning

confidence: 99%

Antifungal activity of the naphthoquinone beta-lapachone against disseminated infection with Cryptococcus neoformans var. neoformans in dexamethasone-immunosuppressed Swiss mice

Medeiros

Pontes-Filho

Câmara

et al. 2010

Braz J Med Biol Res

View full text Add to dashboard Cite

“…In order to contribute to the evaluation of the pharmacological potential of plants in Brazil and to propose new herbal medicines for popular uses with efficacy and safety (Resende et al, 2017), this study aimed to determine the antispasmodic activity of A. brachypoda, because, by the chemotaxonomic criterion, it was observed that other species of the Bignoniaceae presented this activity (Gharib et al, 2007;Cavalcante et al, 2008Cavalcante et al, , 2010. In addition, typical plants of the Brazilian Cerrado, such as those of the genus Arrabidaea, are known to be valuable sources of bioactive compounds (Castro et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Hydroalcoholic extract of leaves of Arrabidaea brachypoda (DC.) Bureau present antispasmodic activity mediated through calcium influx blockage

Monteiro

Costa

Martins³

et al. 2020

Rev. Ciênc. Farm. Básica Apl.

View full text Add to dashboard Cite

Aim: Since other species of the Bignoniaceae Family presented of antispasmodic activity, it was decided, by chemotaxonomic criterion, to determine the antispasmodic activity of the leaves of Arrabidaea brachypoda. Methodology: the segments of the rat jejunum were suspended in glass vats containing specific saline solution, at an appropriate temperature, and after stabilization period, were stimulated by a contractile agent to observe the inhibitory or relaxing effect of EH-FAB. Results: EH-FAB showed the presence of 10 compounds, mainly rutin and it has an antispasmodic activity as it inhibits the phasic component and relaxes the tonic component of the contraction in isolated rat jejunum. To assess the mechanism of antispasmodic action, cumulative curves to the CCh were performed in which a non-competitive antagonism was observed, due to a displacement of the control curve to the right and reduction of the maximum contraction effect (E max). Afterward, the participation of the calcium and/or potassium channels was evaluated by increasing the extracellular potassium, and it was observed that the EH-FAB relaxed the rat jejunum, suggesting the participation of the Ca 2+ channels. To corroborate that hypothesis, the EH-FAB was tested against cumulative curves to Ca 2+ in a free depolarizing solution of Ca 2+ , and it was observed that there was a shift of the curve to the right with a reduction in E max. Conclusions: EH-FAB presents antispasmodic activity in isolated rat jejunum and it is suggested to block the influx of Ca 2+ through voltage-gated calcium channels, signaling the therapeutic potential for the treatment of colic and/or diarrhea.

show abstract

Spasmolytic activity of lapachol and its derivatives, α and β-lapachone, on the guinea-pig ileum involves blockade of voltage-gated calcium channels

Cited by 8 publications

References 35 publications

Anti-inflammatory and cicatrizing properties of the Tabebuia genus: A review

Anti-inflammatory and cicatrizing properties of the Tabebuia genus: A review

Antifungal activity of the naphthoquinone beta-lapachone against disseminated infection with Cryptococcus neoformans var. neoformans in dexamethasone-immunosuppressed Swiss mice

Hydroalcoholic extract of leaves of Arrabidaea brachypoda (DC.) Bureau present antispasmodic activity mediated through calcium influx blockage

Contact Info

Product

Resources

About