Spark plasma sintered β-phase silicon nitride with Sr and Ca as a sintering aid for load bearing medical applications

Pettersson, Maria; Pakdaman, Zohreh; Engqvist, Håkan; Liu, Yi; Shen, Zhifu; Östhols, Erik

doi:10.1016/j.jeurceramsoc.2011.12.027

Cited by 11 publications

(7 citation statements)

References 19 publications

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“…For the XRD pattern of SN, the narrow peaks at 13.4° (100), 23.4° (110), 27.0° (200), 33.5° (101), 36.1° (210), 52.2° (301), and 69.9° (321) could be observed. These peaks were typical characteristic peaks of β phase SN with high crystallization Figure c,d are SEM images and particle size distribution analysis of SN.…”

Section: Resultsmentioning

confidence: 94%

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Microporous Coatings of PEKK/SN Composites Integration with PEKK Exhibiting Antibacterial and Osteogenic Activity, and Promotion of Osseointegration for Bone Substitutes

Yang

Qian

et al. 2019

ACS Biomater. Sci. Eng.

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To improve the antibacterial and osteogenic activities of poly(etherketoneketone) (PEKK), concentrated sulfuric acid (H2SO4) suspension with silicon nitride (SN) microparticle was utilized to modify PEKK surface. Through sulfonation reaction, microporous coatings of PEKK/SN composites were created on PEKK surface, which were integrated with PEKK substrate. The results showed that the content of SN in the microporous coatings increased with the increase of SN content in H2SO4 suspension (PKS without SN, PKSC5 and PKSC10 with 5 and 10 wt % SN content in H2SO4) and that the surface roughness and hydrophilicity of microporous coatings on PEKK were significantly improved with the SN content increasing. In addition, the microporous coating of PKSC10 with high SN content exhibited excellent antibacterial activity due to the synergistic action of the presence of amino (−NH2) and sulfonic acid (−SO3H) groups as well as the improvement of protein absorption. Moreover, the microporous coating of PKSC10 obviously stimulated adhesion, proliferation, and osteogenic differentiation of rat bone mesenchymal stem cells. Furthermore, histological and push-out load evaluation indicated that the microporous coating of PKSC10 significantly promoted osteogenesis and osseointegration in vivo. The results suggested that the microporous coating of PKSC10 with high SN content display good biocompatibility, antibacterial and osteogenic activities, and osseointegration ability, which would have great potential for bone substitutes.

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Section: Resultsmentioning

confidence: 94%

“…These peaks were typical characteristic peaks of β phase SN with high crystallization. 23 Figure 1c,d are SEM images and particle size distribution analysis of SN. It could be seen that the size of SN particles were 2−4 μm, and the particle size distribution of SN was ∼3 μm.…”

Section: Resultsmentioning

confidence: 99%

Microporous Coatings of PEKK/SN Composites Integration with PEKK Exhibiting Antibacterial and Osteogenic Activity, and Promotion of Osseointegration for Bone Substitutes

Yang

Qian

et al. 2019

ACS Biomater. Sci. Eng.

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“…An alternative for biomedical applications may be to select biocompatible sintering aids, such as Ca or Sr, in which only mechanical properties have been examined so far 26 . Additionally, it is believed that the cations from different sintering additives may affect its surface properties and therefore biochemical properties, in order to achieve their cation field strength (CFS) values.…”

Section: Introductionmentioning

confidence: 99%

“…4,8,25 An alternative for biomedical applications may be to select biocompatible sintering aids, such as Ca or Sr, in which only mechanical properties have been examined so far. 26 Additionally, it is believed that the cations from different sintering additives may affect its surface properties and therefore biochemical properties, in order to achieve their cation field strength (CFS) values. CFS values of rare earth (RE) cations with the same coordination number (CN) and valence are inversely proportional to ionic radii (CFS = Z/r 2 where Z = valance and r = ionic radius).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial behavior of oxynitride glasses as a glassy grain boundary phase for silicon nitride‐based ceramics

Akin

Dolekcekic

Webster

2021

Int J of Appl Glass Sci

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Silicon nitride-based ceramics have provided significant advantages due to their high chemical resistance, high elastic modulus, and combination of hardness and fracture toughness (depending on self-reinforcement). Over the past two decades, a significant amount of interest has been generated for the bio-applications of these materials.However, the effect of the grain boundary phase on such applications is still not very well understood. In this study, the effect of different cations on biological (such as antibacterial and cytocompatibilty) and material properties (like wetting angles and isoelectric points [IEP]) of oxynitride glasses, mimicking the grain boundary phase in Si 3 N 4 and SiAlON ceramics, were investigated. Results revealed that the antibacterial behavior and mammalian cell viability were inversely correlated in glasses with rare-earth cation additions. Ca was the best cation when the two properties (bacterial response and cell proliferation) were considered together, and, thus should be further studied for a wide range of applications.

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“…Silicon nitride (Si 3 N 4 ) is a technical ceramic that has been widely used in many industrial applications, such as turbine blades, bearings, cutting tools, and spark plugs [1,2]. In addition to excellent mechanical properties, Si 3 N 4 ceramics have also been reported to be biocompatible and bacteriostatic [3,4]. Owing to the above advantages of Si 3 N 4 , it has been utilized as spinal fusion implants [5].…”

Section: Introductionmentioning

confidence: 99%

Wear Performance of a Novel Silicon Nitride Ceramic for Biomedical Applications

Filho

Engqvist

et al. 2023

Biomedical Materials & Devices

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Ceramic materials are sometimes used as bearing surfaces of joint implants due to their high wear resistance and biocompatibility. Silicon nitride (Si3N4) is one of the ceramics under investigation for such use, owing to its bacteriostatic properties and high wear resistance. Traditional Si3N4 is sintered using Al2O3 and Y2O3 as sintering aids. To improve the biocompatibility and bioactivity of Si3N4, new sintering aids (SrO, MgO, and SiO2) were used in this work. This substitution may however have substantial effects on the wear properties of the material. Hence, the aim of this study was to evaluate these effects. Multidirectional pin-on-disc wear tests against ultra-high molecular weight polyethylene pins were used to this end, running in fetal bovine serum solution at 37 °C for 2 million cycles. The surface roughness, phase composition, and surface morphology of the surfaces were investigated, together with the pH of the wear test lubricant and compared to a traditional Si3N4 composition. XRD and SEM results showed that the prepared ceramics were composed of α- and β-phase Si3N4. The surface roughness of the Si3N4 ceramic discs was in accordance with the biomedical standard, and the wear test results demonstrated that the new ceramics had a low wear factor and a comparable coefficient of friction to Si3N4 ceramics reported in previous work. However, the dissolution of the materials over time may be a concern for biotribological applications, such as long-term use or in other wear couples.

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Spark plasma sintered β-phase silicon nitride with Sr and Ca as a sintering aid for load bearing medical applications

Cited by 11 publications

References 19 publications

Microporous Coatings of PEKK/SN Composites Integration with PEKK Exhibiting Antibacterial and Osteogenic Activity, and Promotion of Osseointegration for Bone Substitutes

Microporous Coatings of PEKK/SN Composites Integration with PEKK Exhibiting Antibacterial and Osteogenic Activity, and Promotion of Osseointegration for Bone Substitutes

Antibacterial behavior of oxynitride glasses as a glassy grain boundary phase for silicon nitride‐based ceramics

Wear Performance of a Novel Silicon Nitride Ceramic for Biomedical Applications

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