Spanlastics gel-A novel drug carrier for transdermal delivery of glimepiride

Spanlastic-laden nanogel as a plausible platform for dermal delivery of bimatoprost with superior cutaneous deposition and hair regrowth efficiency in androgenic alopecia

“…Increasing EA amount was reported to increase spanlastic bilayer membrane fluidity, and thereby, would promote higher drug release. Similar results were reported by Elsaied et al ( Elsaied et al, 2023 ) who highlighted the positive impact of increasing EA concentration on the in vitro release of the antidiabetic drug, glimepiride, from spanlastic vesicles.…”

Topical delivery of extracted curcumin as curcumin loaded spanlastics anti-aging gel: Optimization using experimental design and ex-vivo evaluation

“…At lower ratios of Span® to EA (6:4, 1:1), PDI values were found to be lower, indicating the creation of small, evenly distributed vesicles. This was observed in samples F5, F6, and F11 ( Elsaied et al, 2022 ).…”

“…The EE percentages of Curcumin-loaded Spanlastic dispersions were significantly varied (F value = 428.86, P < 0.05) ranging from 99.788 % for F5 to 97.77 % for F12 as shown in Table 3 this may be due to the lipophilic nature of Curcumin that synergized the activity of Span 60® which promote the formation of stable vesicles in a highly effective entrapment (EE%) due to its lipophilic nature and saturated alkyl chains as reported in the article entitled “Spanlastic nanovesicles for enhanced ocular delivery of vanillic acid: design, in vitro characterization, and in vivo anti-inflammatory evaluation” ( Elsaied et al, 2022 ).…”