Topical delivery of extracted curcumin as curcumin loaded spanlastics anti-aging gel: Optimization using experimental design and ex-vivo evaluation

El Hosary, Rania; Teaima, Mahmoud H.; El-Nabarawi, Mohamed; Yousry, Yousra; Eltahan, Mahmoud; Bakr, Ahmed; Aboelela, Hussein; Abdelmonem, Rehab; Nassif, Rafik M.

doi:10.1016/j.jsps.2023.101912

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Anti-aging/angiogenesis1

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2024

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“…Curcumin, as a natural hydrophobic dissolves easily in substances like dimethyl sulfoxide, acetone, ethanol, and oils [136]. However, it does not demonstrate good permeability through skin [137].…”

Section: Anti-aging/angiogenesismentioning

confidence: 99%

Potential of Curcumin in the Management of Skin Diseases

Kasprzak-Drozd,

Niziński,

Hawrył

et al. 2024

IJMS

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Curcumin is a polyphenolic molecule derived from the rhizoma of Curcuma longa L. This compound has been used for centuries due to its anti-inflammatory, antioxidant, and antimicrobial properties. These make it ideal for preventing and treating skin inflammation, premature skin ageing, psoriasis, and acne. Additionally, it exhibits antiviral, antimutagenic, and antifungal effects. Curcumin provides protection against skin damage caused by prolonged exposure to UVB radiation. It reduces wound healing times and improves collagen deposition. Moreover, it increases fibroblast and vascular density in wounds. This review summarizes the available information on the therapeutic effect of curcumin in treating skin diseases. The results suggest that curcumin may be an inexpensive, well-tolerated, and effective agent for treating skin diseases. However, larger clinical trials are needed to confirm these observations due to limitations in its in vivo use, such as low bioavailability after oral administration and metabolism.

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Section: Anti-aging/angiogenesismentioning

confidence: 99%