Spaceflight and simulated microgravity conditions increase virulence of Serratia marcescens in the Drosophila melanogaster infection model

Gilbert, Rachel; Torres, Medaya; Clemens, Rachel; Hateley, Shannon; Hosamani, Ravikumar; Wade, William F.; Bhattacharya, Sharmila

doi:10.1038/s41526-019-0091-2

Cited by 49 publications

(48 citation statements)

References 61 publications

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“…Serratia ureilytica species were found from extreme environmental habitats (Filippidou et al 2019). Drosophila melanogaster had known to be a source of microbial association host, Serratia was included (Chambers et al 2019;Gilbert et al 2020). Prodigiosin was a red pigment which was the characteristic of this genus (Azman et al 2018).…”

Section: Discussionmentioning

confidence: 99%

The biological prospective of red-pigmented bacteria cultured from contaminated agar media

et al. 2021

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Abstract. Arifiyanto A, Afriani H, Putri MH, Damayanti B, Riyanto CL. 2021. The biological prospective of red-pigmented bacteria cultured from contaminated agar media. Biodiversitas 22: 1152-1159. Contaminated agar media was often depleted due to the growth of microbes, which is undesirable for culture. However, the contaminating microbes usually have a distinctive morphology. This research aimed to identify the potential of red-pigmented bacteria originated from the contamination of Drosophila melanogaster larvae. Fruit fly larvae that grow on contaminated tryptic soy agar were accompanied by the appearance of the red-pigmented bacteria colony. The bacterial colonies were purified by the re-streaking method on tryptic soybean agar. This strain was characterized morphologically, biochemically, and molecularly. Results showed that the MBC1 strain was identified as Serratia marcescens. The various metal susceptibility tests at 25 ppm did not affect the growth of the MBC1 strain. Meanwhile, it was also able to inhibit the growth of certain pathogens such as Aspergillus niger, Candida sp., Fusarium sp., and Rigidoporous sp. Strain MBC1 was able to produce antioxidant compounds. The lipolytic and amylolytic activity can be developed for bioremediate agriculture waste and biosurfactant production.

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Section: Discussionmentioning

confidence: 99%

The biological prospective of red-pigmented bacteria cultured from contaminated agar media

et al. 2021

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“…production of lipases) than the baseline (Sugita et al 2016). Moreover astronauts have shown disorders in their immune system upon spaceflight (Gilbert et al 2020).…”

Section: Space Travel Affects the Skin And Immune Systemmentioning

confidence: 99%

“…Moreover astronauts have shown disorders in their immune system upon spaceflight (Gilbert et al . 2020).…”

Section: Space Travel Affects the Skin And Immune Systemmentioning

confidence: 99%

Gut microbiome and human health under the space environment

Siddiqui

Akbar

Khan

2020

J. Appl. Microbiol.

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The gut microbiome is well recognized to have a pivotal role in regulation of the health and behaviour of the host, affecting digestion, metabolism, immunity, and has been linked to changes in bones, muscles and the brain, to name a few. However, the impact of microgravity environment on gut bacteria is not well understood. In space environments, astronauts face several health issues including stress, high iron diet, radiation and being in a closed system during extended space missions. Herein, we discuss the role of gut bacteria in the space environment, in relation to factors such as microgravity, radiation and diet. Gut bacteria may exact their effects by synthesis of molecules, their absorption, and through physiological effects on the host. Moreover we deliberate the role of these challenges in the dysbiosis of the human microbiota and possible dysregulation of the immune system.

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“…Very recently, Gilbert et al . (2020) found that Serratia marcescens was more lethal to Drosophila melanogaster on the ISS than in ground-based controls and suggested that spaceflight induces a physiological change leading to increased virulence in the pathogen. In contrast, the virulence of clinical pathogens ( Listeria monocytogenes , methicillin-resistant S. aureus (MRSA), Enterococcus faecalis and C. albicans ) against larvae and adult Caenorhabditis elegans reduced in the space environment (Hammond et al ., 2013).…”

Section: Experiments In Space and Ground-based Space Simulation Facilmentioning

confidence: 99%

How the space environment influences organisms: an astrobiological perspective and review

Prasad

Richter

Vadakedath

et al. 2021

International Journal of Astrobiology

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The unique environment of space is characterized by several stress factors, including intense radiation, microgravity, high vacuum and extreme temperatures, among others. These stress conditions individually or in-combination influence genetics and gene regulation and bring potential evolutionary changes in organisms that would not occur under the Earth's gravity regime (1 × g). Thus, space can be explored to support the emergence of new varieties of microbes and plants, that when selected for, can exhibit increased growth and yield, improved resistance to pathogens, enhanced tolerance to drought, low nutrient and disease, produce new metabolites and others. These properties may be more difficult to achieve using other approaches under 1 × g. This review provides an overview of the space microgravity and ionizing radiation conditions that significantly influence organisms. Changes in the genomics, physiology, phenotype, growth and metabolites of organisms in real and simulated microgravity and radiation conditions are illustrated. Results of space biological experiments show that the space environment has significant scientific, technological and commercial potential. Combined these potentials can help address the future of life on Earth, part of goal e of astrobiology.

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Spaceflight and simulated microgravity conditions increase virulence of Serratia marcescens in the Drosophila melanogaster infection model

Cited by 49 publications

References 61 publications

The biological prospective of red-pigmented bacteria cultured from contaminated agar media

The biological prospective of red-pigmented bacteria cultured from contaminated agar media

Gut microbiome and human health under the space environment

How the space environment influences organisms: an astrobiological perspective and review

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