Soybeans as a Phytochemical Reservoir for the Production and Stabilization of Biocompatible Gold Nanoparticles

Shukla, Ravi; Nune, Satish K.; Chanda, Nripen; Katti, Kavita; Mekapothula, Swapna; Kulkarni, Anjali; Welshons, Wade V.; Kannan, Raghuraman; Katti, Kattesh V.

doi:10.1002/smll.200800525

Cited by 181 publications

(142 citation statements)

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“…Recently, the green synthesis or fabrication of Au nanostructures have been considerably studied by using harmless alternative biocompatible molecules such as proteins, peptides, cellulose, soybeans, gellan gum, vitamin B2, starch, and D-glucose as stabilizing or reducing agents [5][6][7][8][9][10][11][12][13][14]. We also developed a facile route for the synthesis of Au nanoparticles by the use of food additives [15].…”

Section: Introductionmentioning

confidence: 99%

Facile green synthesis of gold nanoparticles with gum arabic as a stabilizing agent and reducing agent

Chen

2010

Gold Bull

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A facile, completely green, and cheap route for the synthesis of Au nanoparticles at 25-75°C has been developed by using only hydrogen tetrachloroaurate as the precursor and gum arabic (GA) simultaneously as a reducing agent and a stabilizing agent. No extra reagents are needed. From the analyses of UV/VIS absorption spectra, TEM, HRTEM, SAED, and XRD patterns, the formation of Au nanoparticles with a fcc structure was recognized. The synthesis reaction was usually finished in 2-4 h. Increasing the reaction temperature increased the formation rate but had no significant effect on the optical property and size of Au nanoparticles. With increasing Au(III) ion concentration or GA concentration, the mean diameter of Au nanoparticles slightly increased. Also, the particle size distribution became broader at higher Au(III) ion concentration or lower GA concentration due to the insufficient protection. Although raising the GA concentration was helpful to reduce Au(III) ions completely and stabilize the Au nanoparticles, too high GA concentration was not suitable for the stabilization of Au nanoparticles because the increased intermolecular force of GA might hinder the dispersion of Au nanoparticles. Furthermore, the resultant Au nanoparticles were found to remain highly stable in the NaCl solution.

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Section: Introductionmentioning

confidence: 99%

Facile green synthesis of gold nanoparticles with gum arabic as a stabilizing agent and reducing agent

Chen

2010

Gold Bull

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“…Based on our pioneering efforts in green nanotechnology and Nano medicine, Chanda et al [32], Katti et al [33], Shukla et al [34], Mukherjee et al [35], are exploring to enhance the therapeutic payloads of biologically active phytochemicals in broccoli. Nanotechnology in herbal medicine would therefore allow storage, efficient transport and delivery of reservoir of phytochemical cocktails into the cellular matrix.…”

Section: Uv-vis Absorbance Spectroscopy Analysismentioning

confidence: 99%

Green Synthesis of Selenium Nanoparticles from Broccoli, Characterization, Application and Toxicity

Kapur¹,

Soni²,

Kohli³

2017

Adv Tech Biol Med

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Selenium in broccoliBroccoli belongs to the Brassicaceae family, originated in the Mediterranean regions and distributed in Europe and in the United States. Broccoli is rich in micronutrients such as carotene, vitamin C and folic acid-fibers, phytochemicals such as glucosinolates (GLs) and *Corresponding author: Kanchan Kohli, PhD, Associate Professor, Department of Pharmaceutics, Jamia Hamdard, Hamdard University, New Delhi 110062, India, Tel: +911126059688; E-mail: drkanchankohli@gmail.com AbstractPlant-based diets and phytochemicals present in plants can be used to decrease the risk of cancer. This article deals with Brassica species and broccoli in particular which are associated with reduced risk of several important cancers. These plants mainly contain selenium (Se) covalently bound in a number of different chemical forms which is mainly responsible for its biological activity. Further, several enzymes contain selenium in the form of the unusual selenocysteine amino acid which act on free radicals. Broccoli has the ability to accumulate Se many-fold beyond the concentration of Se present in the soil. Reflecting on the above it can be suggested that development of methods to increase the natural accumulation of Se in broccoli may greatly enhance its health-promoting properties. The present article details about green synthesis of selenium nanoparticles and their methods of characterizations. Green synthesis is a biological procedure which can be achieved can be achieved by using plant extracts. This method is capable of producing SeNPs in a size range of about 50-150 nm, under ambient conditions. It was found that SeNPs are able to inhibit the cell growth by dose-dependent manner. In addition, combination of SeNPs and doxorubicin shows better anticancer effect than individual treatments. The present review also brings to light about the causes and implications of toxic effects posed by Se nanoparticles as well as applications of Se nanoparticles in medicine.Green Synthesis of Selenium Nanoparticles from Broccoli, Characterization, Application and Toxicity Citation: Kapur M, Soni K, Kohli K (2017) Green Synthesis of Selenium Nanoparticles from Broccoli, Characterization, Application and Toxicity. Adv Tech Biol Med 5: 198. doi: 10.4172/2379-1764.1000198 Page 2 of 7 ManaviVolume Se Nanoparticles Characterization [42]An initial characterization of the test substance is imperative before any toxicity screening is commenced. A more extensive and complete characterization, including size distribution, shape, surface area, surface chemistry, crystallinity, porosity, agglomeration state, surface charge, solubility, etc., is recommended for nanomaterials in order to determine the correct correlation between their physicochemical properties and the biological effects they elicit [43][44][45][46].

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“…(7)(8)(9)(10)(11)(12)(13)(14) Various herbs and plant sources occlude powerful antioxidants that are present as photochemical constituents in seeds, stems, fruits and in leaves. (15,16) These naturally occurring antioxidants have existed in human food chain for thousands of years, and are known to be non-toxic to living organisms and to the environment.…”

Section: Introductionmentioning

confidence: 99%

“…We have recently reported the application of phytochemicals available within soy, tea and cumin as dual reducing and stabilizing agents for the synthesis of gold nanoparticles. (8,(12)(13)(14) We herein report the utility of phytochemicals occluded within cinnamon as reducing and stabilizing agents to synthesize biocompatible gold nanoparticles from the precursor gold salts. Phytochemical constituents of cinnamon include up to 1-4% of an essential oil, 5-10% polyphenols, 80-90% carbohydrates, and other ingredients that include gum, mucilage, resin and calcium monoterpenes oxalate.…”

Section: Introductionmentioning

confidence: 99%

“…Although significant research has been made in the production of phytochemical coated gold nano-constructs, little is known about their biodistribution and toxicity under in vivo condition. (8)(9)(12)(13)(14) In fact, guidelines for evaluating the efficacy and toxicity of these nanoparticles for human use are still in the evolutionary phase. In this scenario, it is prudent to investigate and understand the nature of phytochemical stabilized nanoparticles, under in vivo conditions, in ways adopted for the development of various pharmaceuticals.…”

Section: Introductionmentioning

confidence: 99%

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An Effective Strategy for the Synthesis of Biocompatible Gold Nanoparticles Using Cinnamon Phytochemicals for Phantom CT Imaging and Photoacoustic Detection of Cancerous Cells

et al. 2010

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Purpose. The purpose of the present study was to explore the utilization of cinnamon coated gold nanoparticles (Cin-AuNPs) as CT/optical contrast enhancement agent for detection of cancer cells.Methods. Cin-AuNPs were synthesized by a -Green‖ procedure and the detailed characterization has been performed by physic-chemical analysis. Cytotoxicity and cellualar uptake studies were carried out in normal human fibroblast and cancerous (PC-3 and MCF-7) cells respectively. The efficacy of detecting cancerous cells was monitored using photoacoustic technique. In vivo biodistribution was studied after IV injection of Cin-AuNPs in mice and a CT phantom model was generated.Results. Biocompatible Cin-AuNPs were synthesized with high purity. Significant uptake of these gold nanoparticles was observed in PC-3 and MCF-7 cells. Cin-AuNPs internalized in cancerous cells facilitate detectable photoacoustic signals. In vivo biodistribution in normal mouse shows steady accumulation of gold nanoparticles in lungs and rapid clearance from blood. Quantitative analysis of CT values in phantom model reveals that the cinnamon phytochemicals coated AuNPs has reasonable attenuation efficiency. Conclusions.The results indicate that these non-toxic Cin-AuNPs can serve as excellent CT/ photoacoustic contrast enhancement agents and may provide a novel approach toward the tumor detection through nanopharmaceuticals.3

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Soybeans as a Phytochemical Reservoir for the Production and Stabilization of Biocompatible Gold Nanoparticles

Cited by 181 publications

References 102 publications

Facile green synthesis of gold nanoparticles with gum arabic as a stabilizing agent and reducing agent

Facile green synthesis of gold nanoparticles with gum arabic as a stabilizing agent and reducing agent

Green Synthesis of Selenium Nanoparticles from Broccoli, Characterization, Application and Toxicity

An Effective Strategy for the Synthesis of Biocompatible Gold Nanoparticles Using Cinnamon Phytochemicals for Phantom CT Imaging and Photoacoustic Detection of Cancerous Cells

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