Soybean β-Conglycinin Diet Suppresses Serum Triglyceride Levels in Normal and Genetically Obese Mice by Induction of β-Oxidation, Downregulation of Fatty Acid Synthase, and Inhibition of Triglyceride Absorption

Soy β-Conglycinin (7S Globulin) Reduces Plasma and Liver Cholesterol in Rats Fed Hypercholesterolemic Diet

“…These proteins constitute up to 90% of all the protein in the seed. The 7S fraction has been studied as the only source of dietary protein in various experimental designs, using various animals, such as rats, [7][8][9] normal and genetically obese mice, 10 and monkeys.…”

“…Although several studies with rats have found that the soy 7S fraction had no effect on plasma cholesterol and lipoprotein cholesterol concentrations, or only a modest effect that was similar to that of typical SPI, 10,11,13 few studies have explored the effect of oral administration of purified b-conglycinin on the control of dyslipidemia. We hypothesize that the administration of an oral daily dose of soybean 7S globulin (b-conglycinin) may reduce high levels of cholesterol, non-high-density lipoprotein (HDL)-cholesterol, and TG in the plasma and in the liver.…”

Soybean protein fraction digested with neutral protease preparation, “Peptidase R”, produced by Rhizopus oryzae, stimulates innate cellular immune system in mouse

“…Additionally, soybeans have recently been demonstrated to possess a variety of physiological functions including anti-hypercholesterolemic and antitumor activities [1][2][3]. Some of these functions have been reported to be due to soybean proteins and their digests.…”

Effects of Dietary Soybean Peptides on Hepatic Production of Ketone Bodies and Secretion of Triglyceride by Perfused Rat Liver

“…11,12) Soybean protein has also been found to have triglyceride-lowering action. 13,14) Soybean protein accelerates fatty acid -oxidation and suppresses fatty acid and triglyceride syntheses in rats and mice. 1,13,15) In addition, the body fat-reducing effect of soybean protein has been shown in experimental animals.…”

“…13,14) Soybean protein accelerates fatty acid -oxidation and suppresses fatty acid and triglyceride syntheses in rats and mice. 1,13,15) In addition, the body fat-reducing effect of soybean protein has been shown in experimental animals. [16][17][18] Thus soybean protein has activities reducing the levels not only of cholesterol but also of triglyceride.…”