Soybean Product Intake Modifies the Association between Interleukin-10 Genetic Polymorphisms and Gastric Cancer Risk

Abstract

In this study, our aim was to investigate the association of inflammation-related genetic polymorphisms and gastric cancer risk and to examine whether the combined effect of soybean product intake modified cancer risk. Eighty-four incident gastric cancer cases and 336 matched controls were selected from the Korean Multi-Center Cancer Cohort. We selected 14 single nucleotide polymorphisms (SNP) from 5 genes [interleukin (IL)-1beta, IL-2, IL-4, IL-8, and IL-10] and used unconditional logistic regression model to calculate the odds ratios (OR) and 95% CI adjusting for H. pylori seropositivity, smoking, age, sex, enrollment year, and residential area. The risk for gastric cancer in relation to genetic polymorphisms and haplotypes were assessed according to soybean product intake levels. Although no single SNP effect was found, the combined effect between IL-10 gene variants of -592 GG/GA, -819 TC/CC, or -1082 AG/GG and low intake of soybean products had an increased risk for gastric cancer compared with the group with no risk gene variants and a high intake of soybean products (OR [95% CI] = 2.82 [1.04-7.62], 2.75 [1.02-7.44], and 4.34 [1.51-12.5], respectively). Among the low-soybean product intake group, IL-10 CCG haplotype had an increased risk of gastric cancer (OR = 3.38 [1.40-8.13]) relative to the ATA haplotype. Our results suggest that the association between IL-10 genetic polymorphisms and gastric cancer risk was modified by soybean product intake.

Association of Interleukin-10 -1082 a/G (Rs1800896) Polymorphism With Susceptibility to Gastric Cancer: Meta-Analysis of 6,101 Cases and 8,557 Controls

“…After reading the full texts of the remaining 37 articles, we found one article had not sufficient data of genotype for calculating OR and 95% CI, four articles were meta-analyses, and two articles were reviews. Finally, a total of 30 studies (4)(5)(6)(7)(10)(11)(12)(13)(14)(16)(17)(18)(19)(20)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39) published from 2002 and 2015 with 6,101 cases and 8,557 controls met our inclusion criteria. The main characteristics of these studies were listed in TABLE 1.…”

Gene-diet interactions in gastric cancer risk: A systematic review

“…They suggested that capsaicin consumption, H. pylori infection, and IL-1B-31C genotypes may affect gastric carcinogenesis via the same metabolic pathway (e.g., an increased inflammatory response and an altered gastric acidic environment). In South Korea, Ko et al [49] investigated several inflammation-related polymorphisms and found that IL-10 genetic variants and low intake of soybean products increased gastric cancer risk compared with the same variants combined with high consumption of soybean products. Soybeans are a major source of isoflavones (e.g., genisten and daidzein), which have anti-inflammatory and anti-oxidative effects.…”

“…Soybeans are a major source of isoflavones (e.g., genisten and daidzein), which have anti-inflammatory and anti-oxidative effects. In those who consume fewer soybeans, IL-10 genetic variants may allow infection with more virulent H. pylori strains and increase gastric inflammation [49] . Oliveira et al [50] investigated the modifying effects of alcohol on the association between genetic polymorphisms anti-or pro-inflammatory cytokines and gastric cancer risk in Southeast Brazilians but found no significant interactions.…”

A Meta-Analysis of Interleukin-10-1082 Promoter Polymorphism Associated with Gastric Cancer Risk

“…Twenty-two studies (Wu et al, 2002;Wu et al, 2003 Morgan et al, 2006;García-González et al, 2007;Sugimoto et al, 2007;Bai et al, 2008;Crusius et al, 2008;Deng et al, 2008;Zhou et al, 2008a;Kang et al, 2009;Ko et al, 2009;Xiao et al, 2009;Liu et al, 2011;Zhou et al, 2011) were initially included in our meta-analysis. Those 22 studies were preliminarily appropriate to the meta-analysis of the associations with gastric cancer regarding IL-10-1082 A/G SNP.…”

“…Since the year 2002, a lot of studies have focused on the IL-10-1082 G allele association with the susceptibility to gastric cancer, but with mixed or conflicting results (Wu et al, 2002;El-Omar et al, 2003;Wu et al, 2003;Savage et al, 2004;Alpízar-Alpízar et al, 2005;Guo et al, 2005;Lee et al, 2005;Lu et al, 2005;Zambon et al, 2005;Kamangar et al, 2006;Morgan et al, 2006;García-González et al, 2007;Sugimoto et al, 2007;Bai et al, 2008;Crusius et al, 2008;Deng et al, 2008;Zhou, et al, 2008a;Kang et al, 2009;Ko et al, 2009;Xiao et al, 2009;Liu et al, 2011;Zhou et al, 2011). Up to now, there has been just one relevant published meta-analysis regarding IL-10-1082 A/G SNP (Zhou et al, 2008b).…”