A Meta-Analysis of Interleukin-10-1082 Promoter Polymorphism Associated with Gastric Cancer Risk

Interleukin-10 Gene Promoter Polymorphisms and Risk of Gastric Cancer in a Chinese Population: Single Nucleotide and Haplotype Analyses

“…This possibility is also indirectly supported by the finding that patients with cardia GC had a significantly lower frequency of IL10-592 AA genotype than those with non-cardia GC (Zhuang et al, 2010). In addition, our finding of a lack of association of IL10-1082 AG/GG with non-cardia malignancy agrees with a meta-analysis on the non-cardia subtype (Ni et al, 2012). Nevertheless, caution should be taken when interpreting the significance of these findings, since non-cardia GC cases and controls in this study may potentially not be representative of the source population due to the post-hoc nature of the analysis.…”

“…This may reflect known differences in the etiology, pathology, carcinogenesis, and prognosis of cardia and non-cardia GC (Ni et al, 2012), and highlights the potential of masking or underestimating associations in analyzing a GC cohort combining the two subtypes. The inconsistency between non-cardia and overall GC results could be attributable to variations in association with respective GC subtypes.…”

Variants of Interleukin-16 Associated with Gastric Cancer Risk

“…This inconsistency between the non-cardia and cardia gastric cancer results could be induced by the etiology, pathology, carcinogenesis, and prognosis of cardia and non-cardia gastric cancer. This possibility is also indirectly supported by previous studies (Ni et al, 2012;Xue et al, 2012), which indicated a lack of association of Interleukin promoter polymorphisms with risk of non-cardia cancer. Caution should be taken when interpreting the significance of these findings, because the sample size of non-cardia gastric cancer cases and controls in our study are relatively same, and they may not represent the same population.…”

Association of Interleukin-10–1082 Promoter Polymorphism with Gastric Cancer: Appraisal of a Recent Meta-Analysis

“…We believe that our remarks will contribute to more accurate elaboration of the results presented by Ni et al (2012).…”