Variants of Interleukin-16 Associated with Gastric Cancer Risk

Zhang, Tao; Wang, Hui

doi:10.7314/apjcp.2013.14.9.5269

Cited by 18 publications

(20 citation statements)

References 29 publications

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“…The role of Single nucleotide polymorphisms (SNP) in altering expressions or functions of inflammation genes was shown; thus, SNPs could be associated with an altered risk of multiple cancers (Machado et al, 2003;Zhang and Wang, 2013). Today, the important role of pro-inflammatory cytokines during tumor development is increasingly gaining interest.…”

Section: Discussionmentioning

confidence: 99%

Interleukin-12 and Interleukin-6 Gene Polymorphisms and Risk of Bladder Cancer in the Iranian Population

Ebadi

Jahed²,

Mivehchi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Interleukin-12 (IL-12) as an antitumor and interleukin-6 (IL-6) as an inflammatory cytokine, are immunomodulatory products that play important roles in responses in cancers and inflammation. We tested the association between two polymorphisms of IL-12(1188A>C; rs3212227) and IL-6 (-174 C>G) and the risk of bladder cancer in 261 patients and 251 healthy individuals. We also investigated the possible association of these SNPs in patients with high-risk jobs and smoking habits with the incidence of bladder cancer. The genotype distributions of IL-6 (-174 C/G) genotype were similar between the cases and the control groups; however, among patients with smoking habits, the association between IL-6 gene polymorphism and incidence of bladder cancer was significant. After a control adjustment for age and sex, the following results were recorded: CC genotype (OR= 2.11, 95%CI=1.56-2.87, p=0.

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Section: Discussionmentioning

confidence: 99%

Interleukin-12 and Interleukin-6 Gene Polymorphisms and Risk of Bladder Cancer in the Iranian Population

Ebadi

Jahed²,

Mivehchi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…A total of 15 publications regarding IL-16 gene polymorphisms and cancer risk were identified. Nine publications were excluded after reading the full article in detail, because they were editorial comment, letter, case report, other polymorphism of IL-16, without sufficient data, repeated literatures and violated HWE (Thomas et al, 2008;Obara et al, 2010;Azimzadeh et al, 2012;Batai et al, 2012;Lin et al, 2012;Deng et al, 2012;Du, et al, 2012;Hughes et al, 2013;Zhang et al, 2013). The study of Gao et al (2009b) presented separate OR by colorectal and gastric two cancer types and each of them was considered as a separate study.…”

Section: Characteristics Of Studiesmentioning

confidence: 99%

Positive Association Between IL-16 rs11556218 T/G Polymorphism and Cancer Risk: a Meta-analysis

Peng²,

He³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Afifi et al (2004) carried out a case-control study in An Egyptian population, finding that the IL-16 may be considered as a marker of severity of airway inflammation. Wu et al (2011) conducted a study of 157 patients with CAD and 202 healthy controls, and reported that IL-16 genetic variation may be used as a genetic marker for CAD (Gao et al, 2009a,b;Obara, 2010;Li et al, 2011;Azimzadeh et al, 2011;Zhang and Wang, 2013;Luo et al, 2014;Qin et al, 2014). The abovementioned studies reveal that IL-16 gene polymorphisms are associated with cancer development.…”

Section: Discussionmentioning

confidence: 99%

IL-16 rs4778889 polymorphism contribution to the development of renal cell cancer in a Chinese population

et al. 2016

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ABSTRACT. IL-16 plays an important role in affect the secretion of tumor-related inflammatory cytokines. We aimed to assess the role of interleukin-16 (IL-16) rs4778889 T/C and rs11556218 T/G polymorphisms in the occurrence of renal cell cancer (RCC). This study is composed of 274 RCC patients and 274 control subjects. Genotyping of polymorphisms was performed using polymerase chain reaction combined with restriction fragment length polymorphism analysis. All statistical analysis was carried out by the SPSS statistical software package, version 16.0 (SPSS Inc., Chicago, IL, USA). Using conditional logistic regression analysis, the TC and CC genotypes of rs4778889 exhibited a higher risk of RCC, with adjusted ORs (and 95%CIs) of 1.79 (1.23-2.62) and 2.67 (1.29-5.69), respectively. Moreover, under dominant and recessive models, individuals carried the rs4778889 polymorphism was exhibited elevated RCC risk, with adjusted ORs (and 95%CI) of 1.93 (1.35-2.76) and 2.11 (1.05-4.45), respectively. No significant differences were observed in rs11556218 genotype frequencies between the study groups. In conclusion, the results of our study reveal an association between the IL-16 rs4778889 polymorphism and heightened risk of RCC.

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Variants of Interleukin-16 Associated with Gastric Cancer Risk

Cited by 18 publications

References 29 publications

Interleukin-12 and Interleukin-6 Gene Polymorphisms and Risk of Bladder Cancer in the Iranian Population

Interleukin-12 and Interleukin-6 Gene Polymorphisms and Risk of Bladder Cancer in the Iranian Population

Positive Association Between IL-16 rs11556218 T/G Polymorphism and Cancer Risk: a Meta-analysis

IL-16 rs4778889 polymorphism contribution to the development of renal cell cancer in a Chinese population

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