Soybean Isoflavones as an Alternative to Traditional Hormone Replacement Therapy: Are We There Yet?

Burke, Gregory L.; Vitolins, Mara Z.; Bland, Deirdre R.

doi:10.1093/jn/130.3.664s

Cited by 22 publications

(9 citation statements)

References 18 publications

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“…Standard (estrogen combinations) hormone replacement therapy has some adverse effects that make the benefi t/risk profi le questionable for some patients. This subgroup can profi t from the slight effects of phytoestrogens [14] . However, the results from clinical trials are inconsistent.…”

Section: Discussionmentioning

confidence: 99%

Endocrine and Cognitive Effects of Short-Time Soybean Consumption in Women

Celec

Ostatníková

Cagánová³

et al. 2005

Gynecol Obstet Invest

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Background: Soy phytoestrogens are known to influence the hormonal status acting as partial estrogen agonists. Soy-derived food supplements are advised for hormone replacement therapy, prevention of atherosclerosis, age-related cognitive decline and even hormone-dependent cancer, although results from clinical studies are controversial. Whether increased soybean intake can affect the endocrine status and cognitive abilities is largely unknown. Aim: To observe the effects of 1 week of increased soybean intake on sex hormone levels and spatial cognitive abilities in women. Subjects and Methods: 16 young healthy female volunteers were asked to eat 900 g of soybeans within 1 week. Salivary testosterone (T), free and total plasma T, salivary and plasma estradiol (E) were measured by radioimmunoassay before and after the study period. Mental rotation (MR) and spatial visualization (SV) psychological tests were done at the days of sampling. Results: Soybean intake increased total plasma T levels (p < 0.02) while decreasing salivary T (p < 0.01) and not altering free plasma T levels. Salivary and plasma E levels were not changed. The results of MR and SV tests were improved after the study period. Conclusion: Short-time increased soybean intake alters the level of total plasma and salivary T and improves spatial cognition in women. Whether this effect is mediated by modulation of estrogen receptors, changes in sex hormone-binding globulin production or changes in activity of steroid-competent enzymes needs further study.

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Section: Discussionmentioning

confidence: 99%

Endocrine and Cognitive Effects of Short-Time Soybean Consumption in Women

Celec

Ostatníková

Cagánová³

et al. 2005

Gynecol Obstet Invest

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“…Several studies have reviewed the use of soy for HRT (Burke et al, 2000;Kronenberg and Fugh-Berman, 2002). A double-blind parallel multi-center randomized placebo controlled trial of 104 postmenopausal women who took 60 g of isolated soy protein daily (76 mg of isoflavones) versus placebo reported that the mean number of daily hot flushes were significantly reduced in the group consuming soy ( p < 0.01) (Albertazzi et al, 1998).…”

Section: Soymentioning

confidence: 99%

Phytoestrogens: a review of the present state of research

Ososki

Kennelly

2003

Phytotherapy Research

401

278

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Phytoestrogens are a diverse group of plant-derived compounds that structurally or functionally mimic mammalian estrogens and show potential benefits for human health. The number of articles published on phytoestrogens has risen dramatically in the past couple decades. Further research continues to demonstrate the biological complexity of phytoestrogens, which belong to several different chemical classes and act through diverse mechanisms. This paper discusses the classification of phytoestrogens, methods of identification, their proposed mechanisms of action and botanical sources for phytoestrogens. The effects of phytoestrogens on breast and prostate cancers, cardiovascular disease, menopausal symptoms and osteoporosis will also be examined including research on benefits and risks.

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“…They bind strongly to oestrogen β receptors and weakly to oestrogen α receptors, thus exerting organ-specific oestrogenic or anti-oestrogenic activity by blocking the oestrogen receptor and possessing weak oestrogenic activity [10]. Their high consumption in the Japanese population was credited for lower rates of cardiovascular diseases, breast and endometrial cancer mortality and reduced vasomotor symptoms [11]. This led to the widespread use of non-hormonal therapies based on soy isoflavones for the management of menopausal symptoms though scientific evidence for their efficacy is mixed [12].…”

Section: Introductionmentioning

confidence: 99%