The Effect of Soy Isoflavones on the Menopause Rating Scale Scoring in Perimenopausal and Postmenopausal Women: A Pilot Study

Ahsan, Marya; Mallick, Ayaz Khurram

doi:10.7860/jcdr/2017/26034.10654

Cited by 30 publications

(26 citation statements)

References 27 publications

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“…Isoflavones are considered selective estrogen receptor modulators (SERMs) as they can interact with two estrogen receptor subtypes: ER α and ER β [21]. They are widely used as dietary supplement in both animals and human diets [9, 22]. Several studies investigated their usage as HRT in case of estrogen depletion [22–26].…”

Section: Introductionmentioning

confidence: 99%

“…They are widely used as dietary supplement in both animals and human diets [9, 22]. Several studies investigated their usage as HRT in case of estrogen depletion [22–26]. Epidemiological data demonstrated the protective effect of isoflavones against age-related chronic diseases [27] and cardiovascular diseases [28] as well as anti-breast cancer effects which were demonstrated by lower incidence in an eastern Asian population where soy predominates diet [29].…”

Section: Introductionmentioning

confidence: 99%

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Soy Isoflavones Ameliorate Metabolic and Immunological Alterations of Ovariectomy in Female Wistar Rats: Antioxidant and Estrogen Sparing Potential

Abdelrazek

Mahmoud

Tag

et al. 2019

Oxidative Medicine and Cellular Longevity

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Hormone replacement therapy (HRT) can alleviate estrogen deficiency symptoms especially during menopause. The present study aimed at investigating the effect of soy isoflavones as HRT on immunological and bone health-related parameters with a special focus on the interactions between immunological status and metabolism. Thirty healthy cyclic female Wistar rats were used in this experiment. Ten females were sham-operated, and 20 females were subjected to ovariectomy. Overiectomized (OVX) female rats were randomly divided into 2 groups: the control group (G1, OVX/casein) was fed a casein-based diet, and the second group (G2, OVX/soy) was fed a high soy isoflavone diet. Both groups were compared to a sham-operated group (G3, sham/casein). Treatments continued for 7 weeks. Feed intake, weight gain, and lymphoid organ relative weights were recorded. Some metabolic, immunological, and bone health-related parameters were measured. Moreover, nitric oxide (NO), malondialdehyde (MDA), and total antioxidant capacity (TAC) were determined. Bone histopathology and immunohistochemistry to estrogen receptor alpha (ERα) were done. Feeding soy to OVX females reduced feed intake, weight gain, relative lymphoid organ weight, and T-lymphocytes transformation. Soy isoflavone administration normalized nearly all metabolic and immunological parameters to a level comparable to the sham group via oxidative stress amelioration and bone ERα promotion. Soy isoflavones seemed to be good HRT in estrogen deprivation which modulated the appetite, weight gain, lipid profile, proinflammation, and bone turnover.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Soy Isoflavones Ameliorate Metabolic and Immunological Alterations of Ovariectomy in Female Wistar Rats: Antioxidant and Estrogen Sparing Potential

Abdelrazek

Mahmoud

Tag

et al. 2019

Oxidative Medicine and Cellular Longevity

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“…Increase in vaginal dryness, insomnia, lower urinary tract symptoms and emotional lability are also common in this population. [ 2 ]…”

Section: Introductionmentioning

confidence: 99%

An overview of menopausal symptoms using the menopause rating scale in a tertiary care center

Khatoon

Husain

et al. 2018

J Mid-life Health

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Context:Due to increased life expectancy worldwide, women are expected to spend a significant portion of their lives in menopause. Proven prevention strategies against serious risks and tested effective treatments for common symptoms may remain unutilized in our population if these women are not asked about these symptoms.Aim:This study aims to assess the prevalence of different menopausal symptoms and their severity according to menopause rating scale (MRS) in women.Setting and Design:The present study was a cross-sectional survey, conducted in the outpatient department of gynecology and obstetrics.Subjects and Methods:After written and informed consent, 121 women having their last menstrual period at least 1 year ago were included. The menopausal symptoms were assessed using the MRS. The primary outcome measure in this study was the prevalence of menopausal symptoms in these women according to MRS and the severity of these symptoms.Statistical Analysis Used:Data were analyzed using the SPSS software program, version 15.0 (IBM, Armonk, New York, USA).Results:The most common symptom was mental and physical exhaustion which was reported by 88 (72%) women, followed by joint and muscular discomfort which was reported by 83 (68.59%). Hot flushes were reported by 54 (44.62%) respondents. Majority of women reported mild-to-moderate symptoms.Conclusions:The prevalence of menopausal symptoms is high, and a health policy needs to be generated for the region.

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“…Verglichen mit anderen Studien, die mit verschiedenen Östradiolpräparaten durchgeführt wurden, konnte E55 RS eine deutlich höhere Abnahme des pH erzielen [14,15]. Dieser Effekt wurde auch in anderen Studien mit Equolpräparaten zur VVA-Behandlung [8] Die Verbesserung der Wirkung von Phytoöstrogenen auf Wechseljahresbeschwerden wurde auch in anderen Studien berichtet, und da sie das Brustkrebsrisiko nicht erhöhen, haben sie einen großen Vorteil gegenüber der Hormonersatztherapie (HRT; [11,16,17]). Verschiedene Studien haben gezeigt, dass die HRT, insbesondere eine Kombination aus Östrogen und Progesteron, das Risiko für Brust-, Endometriumund Herz-Kreislauf-Erkrankungen erhöht [18][19][20][21].…”

Section: Tab 5 Von Patientinnen Berichtete Symptomeunclassified

Eine Proof-of-concept-Studie von Isoflavandiol-E55-RS-Vaginalkapseln oder Vaginalgel zur Linderung der menopausalen Vaginalatrophie

Mayr¹,

Georgiev

Toulev

2019

J. Gynäkol. Endokrinol. AT

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The Effect of Soy Isoflavones on the Menopause Rating Scale Scoring in Perimenopausal and Postmenopausal Women: A Pilot Study

Cited by 30 publications

References 27 publications

Soy Isoflavones Ameliorate Metabolic and Immunological Alterations of Ovariectomy in Female Wistar Rats: Antioxidant and Estrogen Sparing Potential

Soy Isoflavones Ameliorate Metabolic and Immunological Alterations of Ovariectomy in Female Wistar Rats: Antioxidant and Estrogen Sparing Potential

An overview of menopausal symptoms using the menopause rating scale in a tertiary care center

Eine Proof-of-concept-Studie von Isoflavandiol-E55-RS-Vaginalkapseln oder Vaginalgel zur Linderung der menopausalen Vaginalatrophie

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