Soybean greatly reduces valproic acid plasma concentrations: A food–drug interaction study

Abstract

The aim of this study was to investigate the effects of soy on the pharmacokinetics and pharmacodynamics of valproic acid (VPA). In a preclinical study, rats were pretreated with two different amounts of soy extract for five days (150 mg/kg and 500 mg/kg), which resulted in decreases of 57% and 65% in the Cmax of VPA, respectively. AUC of VPA decreased to 83% and 70% in the soy pretreatment groups. Interestingly, the excretion rate of VPA glucuronide (VPAG) was higher in the soy-fed groups. Levels of UDP-glucuronosyltransferase (UGT) UGT1A3, UGT1A6, UGT2B7 and UGT2B15 were elevated in the soy-treated group, and GABA concentrations were elevated in the brain after VPA administration. However, this was less pronounced in soy extract pretreated group than for the untreated group. This is the first study to report the effects of soy pretreatment on the pharmacokinetics and pharmacodynamics of VPA in rodents.

Role of food-drug interactions in neurological and psychological diseases

“…VPA C max values were decreased to 57% for those pretreated with 150 mg soy, and to 65% for those treated with 500 mg. Of note, gamma aminobutyric acid (GABA) concentrations in the brain were increased within 5 min after VPA injection. In the soy-treated group, concentrations of GABA in the brain were significantly inhibited throughout the entire study period; however, plasma levels of GABA were not significantly different between the treatment and control groups (Marahatta et al 2014).…”

“…Armutcu et al 2004Yilmaz et al 2009Castro-Gago et al 2011 High-fat diet and soy intake with drug should be avoided. Zhang et al 2014Marahatta et al 2014 Gabapentin, pregabalin, carbamazepine and VPA High protein intake may prevent levodopa to cross blood brain barrier. Aksoy 2016Ismail 2009 Selective Serotonin Reuptake Inhibitors (SSRI)…”

Genetic polymorphisms and valproic acid plasma concentration in children with epilepsy on valproic acid monotherapy

“…Limitations of the study include: (1) the sample size was relatively small (137 patients); (2) despite their influence on VPA metabolism, many variants were not selected due to low frequency in the population (MAF < 0.05) [7,20]; (3) possible influence of food-drug interactions on VPA plasma concentration was not evaluated [18].…”

“…Additionally, fooddrug interactions also influence the pharmacokinetics of VPA. For example, soybean intake can greatly decrease the plasma concentration of VPA [18].…”

Анализ Факторов, Влияющих На Подвижность Макромомолекул Гидроксиэтилкрахмалов В Растворе

“…Ïðè ïðîâåäåíèè êëèíè÷åñêèõ èñïûòàíèé ïðèåì ÏÝÑ ïðîâîäèòñÿ â ñòàíäàðòíûõ óñëîâèÿõ, â òî âðåìÿ êàê ïàöèåíòû ìîãóò ïðèíèìàòü ÏÝÑ è äî, è ïîñëå åäû, ÷òî ìîaeåò îêàçàòü âëèÿíèå íà ôàðìàêîêèíåòèêó. Âìåñòå ñ òåì èçâåñòíî, ÷òî, íàïðèìåð, áîãàòàÿ ðàñòèòåëüíûì áåëêîì ïèùà â çíà÷èòåëüíîé ñòåïåíè ñíèaeàåò áèîäîñòóïíîñòü ïðîòèâîñóäîðîaeíûõ ñðåäñòâ [12,28].…”