Soybean diet improves insulin secretion through activation of cAMP/PKA pathway in rats☆

Soy sterols in the regulation of thyroid functions, glucose homeostasis and hepatic lipid peroxidation in mice

“…Soy bean and its isoflavones were earlier known to exhibit beneficial effects in correcting the hyperglycemia and preventing diabetic complications (Aboutabl et al, 2002;Ali, Velasquez, Hansen, Mohamed, & Bhathena, 2005;Blair, Henley, & Tabor, 2006;Lee, 2006;McCue et al, 2005;Palanisamy, Viswanathan, & Anuradha, 2008;Velso et al, 2008). The present observations now indicate a similar type of effect with its sterol component, but at a lower concentration.…”

The soybean peptide aglycin regulates glucose homeostasis in type 2 diabetic mice via IR/IRS1 pathway

“…Prevention of aglycin against the loss of glucose tolerance and abnormal glucose levels in diabetic mice was hence in line with some studies that soybean peptide could improve glucose tolerance [22]. The possibility that aglycin maintained normoglycemia in these mice by increasing insulin secretion was ruled out because aglycin failed to increase insulin release in response to glucose challenge.…”

A 2-month exposure to dietary genistein has sex-dependent effects on serum profile, cardiac protein expression, and aortic morphology in mice

“…This is in contrast to our previous data whereby genistein administration for 1 month increased plasma insulin in males, 11 Several mechanisms have been postulated to explain genistein's stimulatory action on insulin secretion, including inhibition of tyrosine kinase activity 30 and activation of the cAMP/PKA ERK1/2 and PLC/PKC pathways. 31,32 Explaining the increase in insulin sensitivity in tissues is, as expected, primarily due to an increase in expression and translocation of the glucose transporter GLUT4. In skeletal muscle and L6 myotubes, several reports consistently show that genistein increases glucose uptake via up-regulation of both GLUT4 and insulinindependent mechanisms.…”