Soy sterols in the regulation of thyroid functions, glucose homeostasis and hepatic lipid peroxidation in mice

Panda, Sasmita; Kar, Anand; Patil, Sandeep

doi:10.1016/j.foodres.2009.05.001

Cited by 14 publications

(9 citation statements)

References 62 publications

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“…The bean protein hydrolysate (700 mg/kg/day) was formulated according to Mojica et al [12] We know that the bean protein hydrolysate has a yield of 51.2% from the whole bean flour [5], thus, considering the dose of 700 mg per kg of body weight, we can assuming that a 70 kg individual would have to consume about 95.7 g of beans. The 6-propyl-2thiouracil (PTU) (10 mg/kg/day) was used according to Panda and Kar [21] and Panda et al [22] PTU is a thyreostatic agent that inhibits thyroperoxidase enzyme, acts in thyroid hormone synthesis, and increases weight gain, total cholesterol, LDL-c and triglycerides [23]. The diet and PTU were intragastrically administered by oral gavage.…”

Section: Animals and Dietsmentioning

confidence: 99%

Common bean protein hydrolysate modulates lipid metabolism and prevents endothelial dysfunction in BALB/c mice fed an atherogenic diet

Gomes

Lima

Alves

et al. 2020

Nutrition, Metabolism and Cardiovascular Diseases

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Background and aims: Common beans (Phaseolus vulgaris L.) protein hydrolysate is a source of bioactive peptides with known health benefits. The aim of this study was to evaluate the effect of common bean protein hydrolysate on lipid metabolism and endothelial function in male adult BALB/c mice fed an atherogenic diet for nine weeks. Methods and results: Male adult mice were divided into three experimental groups (n Z 12) and fed with normal control diet; atherogenic diet and atherogenic diet added with bean protein hydrolysate (700 mg/kg/day) for nine weeks. Food intake, weight gain, lipid profile, Atherogenic Index of Plasma, inflammation biomarkers and endothelial function were evaluated. APH group presented reduced feed intake, weight gain, lipid profile, tumor necrosis factor-a, angiotensin II (94% and 79%, respectively) and increased endothelial nitric oxide synthase (62%). Conclusions: Protein hydrolysate showed hypocholesterolemic activity preventing inflammation and dysfunction of vascular endothelium, in addition to decreasing oxidative stress, indicating an adjuvant effect on reducing atherogenic risk.

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Section: Animals and Dietsmentioning

confidence: 99%

Common bean protein hydrolysate modulates lipid metabolism and prevents endothelial dysfunction in BALB/c mice fed an atherogenic diet

Gomes

Lima

Alves

et al. 2020

Nutrition, Metabolism and Cardiovascular Diseases

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show abstract

“…Antioxidants such as vitamin C, vitamin E, soy sterols, and polyphenols help protect the cell against oxidant-induced proliferation, lipid peroxidation, glutathione peroxidase activation (Garcia-Alonso, Ros, & Periago, 2006;Ou, Huang, Hampsch-Woodill, Flanagan, & Deemer, 2002), and also contribute to thyroid regulation and glucose homeostasis (Panda, Kar, & Patil, 2009). Evidence indicates that A. cherimola is rich in antioxidants such as vitamins A and C, making it a beneficial health supplement (Garcia, Zepeda-Vallejo, Gallegos, Gonzales, & Madrigal, 2008).…”

Section: Introductionmentioning

confidence: 99%

The antioxidant properties of the cherimoya (Annona cherimola) fruit

Gupta-Elera

Garrett

Martinez

et al. 2011

Food Research International

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“…aldose reductase and this can help prevent the formation of advanced glycation end-products (AGE). There is a great interest in the development of new drugs to prevent the complications associated with this disease and to evaluate natural products in experimental studies (Ali et al, 2008;Bhandari, Anurakkun, Hong, & Kawabata, 2007;Gao, Bjork, Trajkovski, & Uggla, 2000;Kim, Nguyen, Kurihara, & Kim, 2010;Kwon, Apostolidis, & Shetty, 2006;Lee, Garcia, & Parkin, 2010;Mukherjee, Maiti, Mukherjee, & Houghton, 2006;Panda, Kar, & Patil, 2009).…”

Section: Introductionmentioning

confidence: 99%