Rambutan rind in the management of hyperglycemia

Palanisamy, Uma Devi; Manaharan, Thamilvaani; Teng, Ling Lai; Radhakrishnan, Ammu Kutty; Subramaniam, Thavamanithevi; Masilamani, Theanmalar

doi:10.1016/j.foodres.2011.01.048

Cited by 54 publications

(26 citation statements)

References 35 publications

(41 reference statements)

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“…Ethanolic extraction of plant bioactives has displayed a higher yield compared with the aqueous extract [20]. In the present study, we compared rat intestinal α-glucosidase inhibitory activity of different ethanol-aqueous extractions.…”

Section: Resultsmentioning

confidence: 99%

Anti-Hyperglycemic Effect of Chebulagic Acid from the Fruits of Terminalia chebula Retz

Huang

Zhao

Gao

et al. 2012

IJMS

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In the present study, we firstly compared rat intestinal α-glucosidase inhibitory activity by different ethanol-aqueous extractions from the dried fruits of Terminalia chebula Retz. The enzymatic assay showed that the 80% ethanol extract was more potent against maltase activity than both 50% and 100% ethanol extracts. By HPLC analysis, it was determined that the 80% ethanol extract had a higher content of chebulagic acid than each of 50% or 100% ethanol extract. Next, we investigated how efficiently chebulagic acid could inhibit sugar digestion by determining the glucose level on the apical side of the Caco-2 cell monolayer. The result showed that the maltose-hydrolysis activity was down-regulated by chebulagic acid, which proved to be a reversible inhibitor of maltase in Caco-2 cells. On the other hand, chebulagic acid showed a weak inhibition of sucrose-hydrolysis activity. Meanwhile, chebulagic acid did not have an obvious influence on intestinal glucose uptake and was not effective on glucose transporters. Further animal studies revealed that the oral administration of chebulagic acid (100 mg/kg body weight) significantly reduced postprandial blood glucose levels by 11.1% in maltose-loaded Sprague-Dawley (SD) rats compared with the control group, whereas the oral administration of chebulagic acid did not show a suppressive effect on postprandial hyperglycemia in sucrose- or glucose-loaded SD-rats. The results presented here suggest that chebulagic acid from T. chebula can be used to control blood glucose and manage type 2 diabetes, although clinical trials are needed.

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Section: Resultsmentioning

confidence: 99%

Anti-Hyperglycemic Effect of Chebulagic Acid from the Fruits of Terminalia chebula Retz

Huang

Zhao

Gao

et al. 2012

IJMS

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“…25 Roselle also has variety content bioflavonoid such as prunin, myrciacitrin, 6-hydroxyl-flavonoids, 6-hydroxyluteolin, apigenin, and luteolin, that can lower blood glucose, and have inhibitory activity of α-glucosidase. 24 Flavonoid contents of REE are flavonols (gossypetin) and the anthocyanins. 25 Flavonoid and isoflavonoid glycosides are found in human small intestine, in which α-and β-glucosidase inhibitory present to inhibit carbohydrate catalyses 26 that suggests contribution of flavonoid content as antidiabetic effects.…”

Section: Discussionmentioning

confidence: 99%

α-/β-Glucosidase and α-Amylase Inhibitory Activities of Roselle (Hibiscus sabdariffa L.) Ethanol Extract

Gondokesumo

Kusuma²,

Widowati

2017

Mol Cell Biomed Sci

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Background: Diabetes mellitus is a metabolic disease, characterized by hyperglycemia due to disturbance in both insulin secretion and function. One of theurapeutic approaches is to reduce blood glucose levels by inhbiting α-/β-glucosidase and α-amylase involved in carbohydrate digestion. Thus, inhibition of these enzymes play important role in the treatment of diabetes mellitus. Roselle (Hibiscus sabdariffa L.) has been known to have several medicinal properties and potency as an antidiabetics agents. This reseacrh aimed to observe antidiabetic properties of roselle ethanol extract (REE) towards α-glucosidase, β-glucosidase and α-amylase. Materials and Methods: REE was done with maceration technique using diluent of 70% ethanol. Antidiabetic properties were measured by inhibitory activity of α-amylase, α-glucosidase and β-glucosidase. Results: REE was able to inhibit α-/β-glucosidase and α-amylase in the highest concentration with inhibition percentage of 72.68, 47.34 and 73.08% respectively, and were comparable with Acarbose of 81.49, 50.97, 73.08%. The median inhibitory concentration (IC 50 ) of α-/β-glucosidase and α-amylase of REE were 15.81, 41.77, 18.09 µg/mL respectively, and Acarbose were 9.45, 22.57, 3.64 µg/mL respectively. Conclusion: REE inhibits α-/β-glucosidase and α-amylase.

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“…() reported that oxidative stress contributes immensely in development of diabetes (Palanisamy et al. ). This increased oxidative stress is accompanied by a decreased antioxidant capacity.…”

Section: Introductionmentioning

confidence: 99%

“…During the development of Type 2 diabetics mellitus, abnormalities in lipid and carbohydrate metabolism lead to increased oxidative stress which gives rise to high blood sugar level (Palanisamy et al. ). Breaking down of starch by pancreatic α ‐amylase and absorption of glucose by intestinal α ‐glucosidase lead to risen blood glucose level that causes Type 2 diabetes.…”

Section: Introductionmentioning

confidence: 99%

“…It is a disorder associated with insufficient production of endogenous insulins and manifestation of hyperglycemia in the human body (Saravanana and Ponnusamy 2011). Maritim et al (2003) reported that oxidative stress contributes immensely in development of diabetes (Palanisamy et al 2011). This increased oxidative stress is accompanied by a decreased antioxidant capacity.…”

Section: Introductionmentioning

confidence: 99%

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Germinated Pigeon Pea (Cajanus cajan): a novel diet for lowering oxidative stress and hyperglycemia

Uchegbu

Ishiwu

2016

Food Science & Nutrition

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This work studied the antioxidant activity of extract of germinated pigeon pea (Cajanus cajan) in alloxan-induced diabetic rats. Germination was carried out in a dark chamber under room temperature (28°C). The total phenolic, 1,1,diphenyl-2-picrylhy-drazyl free radical (DPPH) scavenging, the inhibition of α-amylase and α-glucosidase were done in vitro and blood glucose levels of the animal were investigated. Lipid peroxidation (LPO) and reduced glutathione (GSH) were analyzed spectrophotometrically. The total phenolic and DPPH scavenging activity increased by 30% and 63%, respectively, after germinating pigeon pea. Also after germination there was an increase in the inhibitory potential of pigeon pea extract against α-glucosidase compared with the nongerminated pigeon pea extract. There was a significant increase (P < 0.05) in fasting blood glucose level of alloxan-induced rats. Consumption of germinated pigeon pea extract gave rise to a reduced fasting blood glucose level in diabetic rats. On administration of germinated pigeon pea extract, LPO reduced drastically but there was an increase in the level of GSH. This study concluded that intake of germinated pigeon pea is a good dietary supplement for controlling hyperglycemia and LPO. 773

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Rambutan rind in the management of hyperglycemia

Cited by 54 publications

References 35 publications

Anti-Hyperglycemic Effect of Chebulagic Acid from the Fruits of Terminalia chebula Retz

Anti-Hyperglycemic Effect of Chebulagic Acid from the Fruits of Terminalia chebula Retz

α-/β-Glucosidase and α-Amylase Inhibitory Activities of Roselle (Hibiscus sabdariffa L.) Ethanol Extract

Germinated Pigeon Pea (Cajanus cajan): a novel diet for lowering oxidative stress and hyperglycemia

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