Soybean Bioactive Components and their Implications to Health—A Review

Isanga, Joel; Guo-nong, Zhang

doi:10.1080/87559120801926351

Cited by 135 publications

(82 citation statements)

References 175 publications

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“…Previous studies in several laboratories including our own (Xiao et al 2008;Al-Dwairi et al 2012;Yeh et al 2014;Isanga and Zhang 2011) have shown that soybean components when consumed can favorably affect metabolic pathways and associated genes in animal models and in humans. Moreover, in a mouse model of breast cancer and in breast cancer cells in vitro, dietary intake of soy protein isolate and treatment with Gen, respectively, decreased the frequency of the mammary basal stem celllike subpopulation, which was associated with decreased mammary tumor incidence and oncogenic molecular profile (Montales et al 2012;Rahal et al 2013).…”

Section: Discussionmentioning

confidence: 92%

Metformin and soybean-derived bioactive molecules attenuate the expansion of stem cell-like epithelial subpopulation and confer apoptotic sensitivity in human colon cancer cells

et al. 2015

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Colorectal cancer (CRC) is a disease whose genesis may include metabolic dysregulation. Cancer stem cells are attractive targets for therapeutic interventions since their aberrant expansion may underlie tumor initiation, progression, and recurrence. To investigate the actions of metabolic regulators on cancer stem cell-like cells (CSC) in CRC, we determined the effects of soybeanderived bioactive molecules and the anti-diabetes drug metformin (MET), alone and together, on the growth, survival, and frequency of CSC in human HCT116 cells. Effects of MET (60 lM) and soybean components genistein (Gen, 2 lM), lunasin (Lun, 2 lM), b-conglycinin (bcon, 3 lM), and glycinin (Gly, 3 lM) on HCT116 cell proliferation, apoptosis, and mRNA/protein expression and on the frequency of the CSC CD133 ? CD44 ? subpopulation by colonosphere assay and fluorescence-activated cell sorting/flow cytometry were evaluated. MET, Gen, and Lun, individually and together, inhibited HCT116 viability and colonosphere formation and, conversely, enhanced HCT116 apoptosis. Reductions in frequency of the CSC CD133 ? CD44 ? subpopulation with MET, Gen, and Lun were found to be associated with increased PTEN and reduced FASN expression. In cells under a hyperinsulinemic state mimicking metabolic dysregulation and without and with added PTEN-specific inhibitor SF1670, colonosphere formation and frequency of the CD133 ? CD44 ? subpopulation were decreased by MET, Lun and Gen, alone and when combined. Moreover, MET ? Lun ? Gen co-treatment increased the pro-apoptotic and CD133 ?-CD44 ? -inhibitory efficacy of 5-fluorouracil under hyperinsulinemic conditions. Results identify molecular networks shared by MET and bioavailable soy food components, which potentially may be harnessed to increase drug efficacy in diabetic and non-diabetic patients with CRC.

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Section: Discussionmentioning

confidence: 92%

Metformin and soybean-derived bioactive molecules attenuate the expansion of stem cell-like epithelial subpopulation and confer apoptotic sensitivity in human colon cancer cells

et al. 2015

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“…The development of soy-based products, spurred by their nutritional profile, low cost, and good functional properties, has increasingly constituted an important part in the Western diet (ISANGA;ZHANG, 2008;MESSINA;MESSINA, 2000;POTTER et al, 2007;SHAMSUDDIN, 2002;TORRES-PENARANDA;REITMEIER, 2001). …”

Section: Introductionmentioning

confidence: 99%

Soymilk plain beverages: correlation between acceptability and physical and chemical characteristics

2013

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“…Transgenic soybean is included in agriculture technology to increase productivity primarily by reducing inputs and thus production cost (Persley et al, 1999). Soybean is gaining importance as a nutritionally important crop and also becoming popular for nutraceutical properties as it contains essential amino acid and secondary metabolites such as isoflavone, saponins, phytic acids, phytosterols, trypsin inhibitors and peptides (Isanga and Zhang, 2008). Soy, isoflavone daidzein and genistein, their precursors formononetin, biochanin A, their glycosides, glycosides malonates and acetyl glycosides were determined in red clover (Trifolium pratense) extracts using chromatographic and spectrometric methods (Sabudak and Guler, 2009) that are natural phytoestrogens able to inhibit LDL oxidation, thus decreasing the risk of atherosclerosis (Wiseman, 1999).…”

Section: Soybean and Health Benefitmentioning

confidence: 99%

“…Wiseman et al (2000) reported a decrease in susceptibility of LDL particles to oxidation with soy protein consumption. Isanga and Zhang (2008) reported that the phytochemicals contained in soybean as functional ingredients influences the reduction of cholesterol and prevention of cardiovascular diseases, diabetic symptoms, bone lose straight and cancer. Messina and Lane (2007) suggested that soybean-based food can help to reduce the level of cholesterol, soybean will help to this change since provide quality protein, in addition is low in saturated fat and is devoid of cholesterol.…”

Section: Soybean and Health Benefitmentioning

confidence: 99%

Nutraceutical Potential of Soybean: Review

Tidke¹,

Ramakrishn²,

Kiran³

et al. 2015

Asian J. of Clinical Nutrition

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Soybean has received the status as one of the most important edible plants known for its seeds as a source of protein, oil and nutraceuticals. The content of the isoflavones and folic acid has made it a versatile crop for health food applications. The utility of soybean crop for food applications is described. The soybean proteins are gaining importance as a vegetable source for protein based products, with abundance quantity of essential amino acids. Its content of quality fats and PUFA are also important from nutraceutical point of view. The fermented soybean meal is also a good source of nutritionally rich tofu. In addition the biological properties of isoflavones and folic acid add value to the formulations which has been described here. Patents filed for innovations in products and processes have gained popularity and holds promise for the future of soybean industry.

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Soybean Bioactive Components and their Implications to Health—A Review

Cited by 135 publications

References 175 publications

Metformin and soybean-derived bioactive molecules attenuate the expansion of stem cell-like epithelial subpopulation and confer apoptotic sensitivity in human colon cancer cells

Metformin and soybean-derived bioactive molecules attenuate the expansion of stem cell-like epithelial subpopulation and confer apoptotic sensitivity in human colon cancer cells

Soymilk plain beverages: correlation between acceptability and physical and chemical characteristics

Nutraceutical Potential of Soybean: Review

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