Soy β-conglycinin improves obesity-induced metabolic abnormalities in a rat model of nonalcoholic fatty liver disease

Wanezaki, Satoshi; Tachibana, Nobuhiko; Nagata, Morio; Saito, Shintaro; Nagao, Koji; Yanagita, Teruyoshi; Kohno, M.

doi:10.1016/j.orcp.2014.03.005

Cited by 41 publications

(34 citation statements)

References 22 publications

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“…Testis weight differences are discussed below. Soy protein has been reported to have beneficial effects on kidney function (Ogborn et al, 1998; Ogborn et al, 2010), and soy protein has been reported to lower liver weight, as well as reduce serum and liver cholesterol and triglycerides (Ascencio et al, 2004; Nagata et al, 1981; Torre-Villalvazo et al, 2008; Wanezaki et al, 2015), although the latter effects were not observed in the present study. While there were no significant diet effects on ovary weights, there was a higher incidence of gross ovarian cysts in the three low isoflavone diets compared to the NIH-41 diet.…”

Section: Discussioncontrasting

confidence: 63%

Comparison of endpoints relevant to toxicity assessments in 3 generations of CD-1 mice fed irradiated natural and purified ingredient diets with varying soy protein and isoflavone contents

Camacho

Lewis²,

Vanlandingham

et al. 2016

Food and Chemical Toxicology

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Diet is an important variable in toxicology. There are mixed reports on the impact of soy components on energy utilization, fat deposition, and reproductive parameters. Three generations of CD-1 mice were fed irradiated natural ingredient diets with varying levels of soy (NIH-41, 5K96, or 5008/5001), purified irradiated AIN-93 diet, or the AIN-93 formulation modified with ethanol-washed soy protein concentrate (SPC) or SPC with isoflavones (SPC-IF). NIH-41 was the control for pairwise comparisons. Minimal differences were observed among natural ingredient diet groups. F0 males fed AIN-93, SPC, and SPC-IF diets had elevated glucose levels and lower insulin levels compared with the NIH-41 group. In both sexes of the F1 and F2 generations, the SPC and SPC-IF groups had lower body weight gains than the NIH-41 controls and the AIN-93 group had an increased percent body fat at postnatal day 21. AIN-93 F1 pups had higher baseline glucose than NIH-41 controls, but diet did not significantly affect breeding performance or responses to glucose or uterotrophic challenges. Reduced testes weight and sperm in the AIN-93 group may be related to low thiamine levels. Our observations underline the importance of careful selection, manufacturing procedures, and nutritional characterization of diets used in toxicological studies.

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Section: Discussioncontrasting

confidence: 63%

Comparison of endpoints relevant to toxicity assessments in 3 generations of CD-1 mice fed irradiated natural and purified ingredient diets with varying soy protein and isoflavone contents

Camacho

Lewis²,

Vanlandingham

et al. 2016

Food and Chemical Toxicology

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show abstract

“…Soy β-conglycinin was recently reported to modulate de novo lipogenesis by inhibiting hepatic fatty acid synthase mRNA expression and enzymatic activity, with concomitant decrease observed in the levels of hepatic lipids (triglycerides, TG; total cholesterol, TC; phospholipids, PL) and liver weight in OLEFT rats with non-alcoholic fatty liver disease [9]. Hypolipidemic activities have also been observed for squid homogenate [10], chicken protein extract [11], soy proteins [12] and fermented milk [13] in different dyslipidemic rat models.…”

Section: Dietary Peptides and Hyperlipidemiamentioning

confidence: 99%

The Role of Food Peptides in Lipid Metabolism during Dyslipidemia and Associated Health Conditions

Udenigwe

Rouvinen‐Watt

2015

IJMS

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Animal and human clinical studies have demonstrated the ability of dietary food proteins to modulate endogenous lipid levels during abnormal lipid metabolism (dyslipidemia). Considering the susceptibility of proteins to gastric proteolytic activities, the hypolipidemic functions of proteins are possibly due, in part, to their peptide fragments. Food-derived peptides may directly modulate abnormal lipid metabolism in cell cultures and animal models of dyslipidemia. The peptides are thought to act by perturbing intestinal absorption of dietary cholesterol and enterohepatic bile acid circulation, and by inhibiting lipogenic enzymatic activities and gene expression in hepatocytes and adipocytes. Recent evidence indicates that the hypolipidemic activities of some peptides are due to activation of hepatic lipogenic transcription factors. However, detailed molecular mechanisms and structural requirements of peptides for these activities are yet to be elucidated. As hypolipidemic peptides can be released during enzymatic food processing, future studies can explore the prospects of combating metabolic syndrome and associated complications using peptide-rich functional food and nutraceutical products.

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“…The interest on functional foods has increased due to several benefits in a diversity of illness [3]. Particularly, it has been reported that some seed protein isolates from soybean, barley, amaranth, quinoa, and linseed have a positive biological activity against several metabolic disorders, as shown in studies in disease models such as diet-induced obesity [4], streptozotocin-induced diabetes [5,6], proliferation of cancer cells [7] and alcohol-induced cirrhosis [8].…”

Section: Introductionmentioning

confidence: 99%

Amaranth Protein Improves Lipid Profile and Insulin Resistance in a Diet-induced Obese Mice Model

Escobedo-Moratilla¹,

Velarde‐Salcedo²,

Magaña-Hernández³

et al. 2017

JFNR

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Amaranth has been claimed as functional food, but its function on obesity-related disorder is not fully known. The aim of this study was to analyse the effect of amaranth protein intake on blood lipids profile and insulin resistance in diet-induced obese mice. The effect of soybean protein was also analysed for comparative purposes. C57BL-6 mice were fed for eight weeks with regular or high fat diet. Amaranth or soybean protein isolates (10 mg/kg) were supplied via oral administration. Changes in body weight, adipose tissue, total cholesterol, triglycerides, insulin, a glucose tolerance test, as well as the expression of lipid metabolism-related genes were measured. Our results have shown that amaranth protein induces a decrease in plasma insulin in mice fed with a regular diet, whereas a decrease in triglycerides was observed in mice fed with high fat diet. Furthermore, down-regulation of Tnf-α and Res, suggested the inhibition of inflammation state. The present study demonstrates that amaranth protein, but not soybean protein, improves the obese mice health, and the hormonal modulation (Lep, Fasn, Lpl) could lead to new mechanism of action by which amaranth consumption exerts its beneficial health effect.

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Soy β-conglycinin improves obesity-induced metabolic abnormalities in a rat model of nonalcoholic fatty liver disease

Cited by 41 publications

References 22 publications

Comparison of endpoints relevant to toxicity assessments in 3 generations of CD-1 mice fed irradiated natural and purified ingredient diets with varying soy protein and isoflavone contents

Comparison of endpoints relevant to toxicity assessments in 3 generations of CD-1 mice fed irradiated natural and purified ingredient diets with varying soy protein and isoflavone contents

The Role of Food Peptides in Lipid Metabolism during Dyslipidemia and Associated Health Conditions

Amaranth Protein Improves Lipid Profile and Insulin Resistance in a Diet-induced Obese Mice Model

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