Soy protein with and without isoflavones fails to substantially increase postprandial antioxidant capacity

Heneman, Karrie; Chang, Hebron C.; Prior, Ronald L.; Steinberg, Francene M.

doi:10.1016/j.jnutbio.2006.03.001

Cited by 25 publications

(20 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Among different cultivars, GL subunits varied; for example A3 chain ranged between 0.0 and 6.9%; A1,2,4 chains between 0.4 and 19.2%; and basic 0.0 and 20.2% of total protein. Cultivars 2,3,7,8,9,10 lacked the GL subunit A3, whereas cultivar 5 had the highest A3 subunit (~6.9%). Cultivar 6 had the highest content in A1,2,4 subunit of GL with approximately 19.2%.…”

Section: Resultsmentioning

confidence: 96%

See 1 more Smart Citation

Antioxidant Capacity of Alcalase Hydrolysates and Protein Profiles of Two Conventional and Seven Low Glycinin Soybean Cultivars

Darmawan

Bringe

Mejía

2010

Plant Foods Hum Nutr

View full text Add to dashboard Cite

Soy protein hydrolysates are considered a potential dietary source of natural antioxidants with important biological activities. This study was conducted to compare the effect of two conventional and seven low glycinin soybean cultivars on the antioxidant capacity (AC) of soy hydrolysates. Nine cultivars were grown in Bloomington, IL, Findlay, OH and Huxley, IA. The hydrolysates were produced enzymatically using alcalase and analyzed for AC using oxygen radical absorbance capacity (ORAC) assay and soluble protein. Statistical differences were observed in the protein profiles and AC among the different cultivars tested (P < 0.05). The hydrolysate from low glycinin cultivar 3 enriched in β-conglycinin, grown in Bloomington, exhibited the highest AC, compared to the other cultivars across all locations. On average, soy cultivars rich in BC and purified BC hydrolysates (36.2 and 31.8 μM Trolox equivalents (TE)/μg soluble protein, respectively) (P>0.05) had higher AC than purified glycinin (GL) hydrolysate (28.5 μM TE/μg soluble protein) (P<0.05). It was possible to select a soybean cultivar that produced a higher antioxidant capacity upon alcalase hydrolysis.

show abstract

Section: Resultsmentioning

confidence: 96%

“…The postprandial antioxidant protection imparted by a significant increase in human serum antioxidant capacity was not detectable following acute consumption of 25 g soy protein [10]. However, the antioxidant capacity (AC) of soybean is improved when intact protein is hydrolyzed into peptides [11].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Capacity of Alcalase Hydrolysates and Protein Profiles of Two Conventional and Seven Low Glycinin Soybean Cultivars

Darmawan

Bringe

Mejía

2010

Plant Foods Hum Nutr

View full text Add to dashboard Cite

show abstract

“…In our study, we found that rats fed peptic-digested soy protein had lower MDA levels in the heart and aorta, while no changes in circulating MDA were found. However, soy protein with or without isoflavones showed no direct effect on the antioxidant capacity [27]. This indicates that SPH may improve vascular functions not directly by scavenging free radicals but by reducing the production of free radicals through lowering angiontensin II level.…”

Section: Discussionmentioning

confidence: 86%

Soy protein hydrolysate ameliorates cardiovascular remodeling in rats with l-NAME-induced hypertension

Yang

Chen

et al. 2008

The Journal of Nutritional Biochemistry

View full text Add to dashboard Cite

“…Indeed, epidemiological studies have shown that Asian people consuming soy in their staple diet present much lower mortality and morbidity from cardiovascular disease than their counterparts in Western counties (Heneman et al, 2007). However, lentils, chickpeas, peas, and beans are the legumes more commonly consumed in Western countries but it has also been demonstrated that a non soybean legumes-based hypocaloric diet induced a higher decrease in blood lipids concentrations as well as lower lipid peroxidation markers related to obesity comorbidities as compared to a conventional and balanced hypocaloric diet (Crujeiras et al, 2007a).…”

Section: Diets With Recognized Benefits On Oxidative Stress and Healtmentioning

confidence: 99%

Compounds with Antioxidant Capacity as Potential Tools Against Several Oxidative Stress Related Disorders: Fact or Artifact?

Pérez-Matute¹,

Crujeiras²,

Fernández‐Galilea³

et al. 2012

Oxidative Stress and Diseases

View full text Add to dashboard Cite

Oxidative Stress and Diseases 544 reactive species: reactive oxygen species (ROS, thus, oxygen-containing molecules that are highly reactive), reactive chlorine species (RCN) and reactive nitrogen species (RNS). All these reactants contain free radicals as well as nonradicals. Low concentrations of these reactive species are necessary for normal cell redox status, cell function and intracellular signalling (Droge, 2002;Valko et al., 2007;Perez-Matute et al., 2009). However, in some disease states, free radicals are produced in excess and can damage DNA, proteins, carbohydrates and lipid constituents and compromise cell function leading to the development of type 2 diabetes, atherosclerosis, obesity, arthritis etc. Thus, it is clear that excessive production of free radicals causes damage to biological material and is an essential event in the aetiopathogenesis of various diseases. However, the question that has risen in the past years is whether uncontrolled formation of ROS is a primary cause or a downstream consequence of the pathological processes. In other words, it is still not clear what comes first, the chicken or the egg. However, what is clear is that there must be a balance between these reactive species and the antioxidants, whose main function is to counteract the deleterious effects of these reactive species. In fact, antioxidant is defined as any substance that when present at low concentrations compared with those of an oxidizable substrate, significantly delays or prevents oxidation of that substrate (Halliwell & Gutteridge, 1999). These defences include both enzymatic (superoxide dismutases, glutathione peroxidase, catalase, thioredoxin) and non-enzimatic systems (vitamins such as vitamin C, E, A, minerals such as selenium, zinc, cooper, bilirrubine, uric acid, some aminoacids etc).Several studies have demonstrated an increased oxidative state (either caused by an increased ROS production or diminished levels of antioxidants) in serious pathologies such as obesity, cardiovascular diseases, metabolic syndrome, cancer etc. Thus, oxidative stress actually may be related with the mentioned processes. In this context, it is tempting to suggest that if oxidative damage significantly contributes to disease pathology, then, actions that decrease it (via decreasing ROS production or increasing endogenous levels of antioxidants) might be therapeutically beneficial. In fact, attenuation or complete suppression of oxidative stress as a way to improve several diseases has flourished as one of the main challenges of research in the last years. Thus, several approaches have been carried out in order to either decrease the high levels of ROS generated or boost the endogenous levels of antioxiants. Inhibition of ROS production through the development of inhibitors (natural or chemical) against the main sources of ROS generation offers an interesting approach. Thus, NADPH oxidase and mitochondria have been postulated as the main targets to reduce ROS production (reviewed by Pérez-Matute et al., 2009). Another str...

show abstract

Soy protein with and without isoflavones fails to substantially increase postprandial antioxidant capacity

Cited by 25 publications

References 54 publications

Antioxidant Capacity of Alcalase Hydrolysates and Protein Profiles of Two Conventional and Seven Low Glycinin Soybean Cultivars

Antioxidant Capacity of Alcalase Hydrolysates and Protein Profiles of Two Conventional and Seven Low Glycinin Soybean Cultivars

Soy protein hydrolysate ameliorates cardiovascular remodeling in rats with l-NAME-induced hypertension

Compounds with Antioxidant Capacity as Potential Tools Against Several Oxidative Stress Related Disorders: Fact or Artifact?

Contact Info

Product

Resources

About