Soy protein hydrolysate ameliorates cardiovascular remodeling in rats with l-NAME-induced hypertension

Yang, Hsin Yi; Yang, Shumei; Chen, Shu Tzu; Chen, Jiun Rong

doi:10.1016/j.jnutbio.2007.11.004

Cited by 33 publications

(18 citation statements)

References 36 publications

(36 reference statements)

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“…However, previous studies also reported a significant increase in TNF-␣ mRNA and protein synthesis in a time period as short as 30 -60 min in response to different stimuli like ANG II (19), coronary artery occlusion (12), hindlimb ischemia-reperfusion (28), or TNF-␣ itself (42). An increase in plasma TNF-␣ levels occurred in response to systemic L-NAME administration either chronically (6,45,48) or acutely (24 -26) in many pathological conditions. Of course, the appearance of TNF-␣ in the plasma in the present study implies excessive overall tissue production of this cytokine in response to systemic NOS inhibition.…”

Section: Discussionmentioning

confidence: 97%

Involvement of tumor necrosis factor-α in natriuretic response to systemic infusion of nitric oxide synthase inhibitor in anesthetized mice

Shahid

Francis

Matrougui

et al. 2010

American Journal of Physiology-Renal Physiology

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Similar renal responses were also observed during systemic infusion of nitric oxide (NO) synthase inhibitors as opposed to their usual antinatriuretic responses when administered intrarenally. In the present study, we examined the hypothesis that acute NO blockade systemically induces TNF-␣ generation. which induces this natriuretic response. Renal responses to intravenous infusion of the NO synthase inhibitor nitro-L-arginine methyl ester (L-NAME; 0.2 g·min Ϫ1 ·g body wt Ϫ1 for 85 min) and its impact on the plasma level of TNF-␣ were evaluated in anesthetized mice. Plasma TNF-␣ was undetected in untreated mice (n ϭ 7) but was elevated in L-NAME-treated mice (109 Ϯ 22 pg/ml; P Ͻ 0.01 vs. untreated group; n ϭ 7) along with an increase in TNF-␣ protein expression in kidney tissue. L-NAME infusion caused a usual increase in mean arterial pressure (MAP; 98 Ϯ 3 to 122 Ϯ 3 mmHg; P Ͻ 0.01) and decreases in renal blood flow (RBF; 8.6 Ϯ 0.3 to 4.4 Ϯ 0.2 ml · min Ϫ1 ·g Ϫ1 ; P Ͻ 0.01) and glomerular filtration rate (GFR; 1.14 Ϯ 0.07 to 0.77 Ϯ 0.04 ml · min Ϫ1 ·g Ϫ1 ; P Ͻ 0.01) with a marked increase in sodium excretion (U NaV; 0.48 Ϯ 0.10 to 3.52 Ϯ 0.85 mol · min Ϫ1 ·g Ϫ1 ; P Ͻ 0.01). Interestingly, in mice (n ϭ 7) pretreated with the TNF-␣ blocker etanercept (5 mg/kg sc), the U NaV response to L-NAME infusion was markedly blunted (0.58 Ϯ 0.08 to 1.22 Ϯ 0.28 mol · min Ϫ1 ·g Ϫ1 ; P ϭ NS) although responses for MAP, RBF, and GFR were mostly unchanged. However, pretreatment with the superoxide scavenger tempol in mice (n ϭ 7) did not alter the U NaV response to L-NAME. These data demonstrate that L-NAME-induced natriuresis is mediated, at least in part, by concomitant generation of TNF-␣ during NO blockade.

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Section: Discussionmentioning

confidence: 97%

Involvement of tumor necrosis factor-α in natriuretic response to systemic infusion of nitric oxide synthase inhibitor in anesthetized mice

Shahid

Francis

Matrougui

et al. 2010

American Journal of Physiology-Renal Physiology

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“…Many reports have demonstrated that soy protein and its major component, βCG, have the potential to prevent and treat hyperglycemia and diabetes mellitus (Cederroth, et al, 2008;Lu, et al, 2008;Yang, et al, 2008;Tachibana, et al, 2014). We previously reported that consumption of βCG improves postprandial hyperglycemia by promoting GLUT4 translocation to the plasma membrane in skeletal muscle of a rat model of diabetes (Tachibana, et al, 2014).…”

Section: Discussionmentioning

confidence: 97%

“…In addition, soy protein hydrolysates derived from pepsin digestion have been shown to lower blood pressure and suppress angiotensin-converting enzyme (ACE) activity in rats with Nω-nitro-l-arginine methyl ester hydrochlorideinduced hypertension (Yang, et al, 2008). This result suggests that soy protein peptides contribute to the beneficial effects of soy protein.…”

Section: Introductionmentioning

confidence: 99%

β-Conglycinin Peptides Improve Glucose Uptake through the AMPK Signaling Pathway in L6 Myotubes

Yamashita

Ueda-Wakagi

Sakamoto

et al. 2015

FSTR

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“…Heart weight-to-body weight ratio (H/BW, mg/g index) was calculated (35). Excised heart and aorta samples were cleared of blood and immediately fixed in 10% formalin.…”

Section: Histopathology Of Heart and Aortamentioning

confidence: 99%

Passiflora quadrangularis L. PREVENTS EXPERIMENTAL HYPERTENSION AND VASCULAR REMODELLING IN RATS EXPOSED TO NITRIC OXIDE DEFICIT

Bareño

Puebla

Guerra

et al. 2017

Vitae

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Background: Passiflora quadrangularis L. is among the species used in Colombian folk medicine for hypertension, but until now it has not been studied in experimental models. Objectives: To assess the capacity of P. quadrangularis L. EtOH extract to prevent the hypertension and vascular remodelling induced by nitric oxide (NO) deficit in Wistar rats. Methods: The nitric oxide (NO) synthase inhibitor L-NAME (10 mg/kg, i.p (intraperitoneal), every 48h) was administered for seven weeks to the following groups of rats: P. quadrangularis L.75, 150 and 300 mg/kg/d, p.o. (oral route); enalapril as reference agent, 10 mg/kg/d, p.o. and vehicle as control (mixture of propylene glycol 10%, glycerine 10% and polysorbate 2%). Arterial blood pressure (BP) and heart rate (HR) were measured twice a week. After sacrifice, the aortic rings were isolated, contraction was triggered with phenylephrine (PE 10 -6 M) and then the relaxant response achieved with cumulative concentrations of acetylcholine (ACh, 10 -10 -10 -5 M) or sodium nitroprusside (SNP, 10 -10 -10 -5 M) was assessed. Histopathologic measures of thickness/lumen ratio from both the left ventricle and aorta walls, as well as phytochemical screening, were also performed. Results: As for enalapril, all doses of P. quadrangularis L. prevented the hypertension induced by L-NAME (122±1.2 versus 155±1.3 mmHg at seventh week). P. quadrangularis L. significantly increased the relaxant effect induced by ACh in isolated aorta and decreased the thickness/lumen ratio of aorta wall specimens. Conclusions: P. quadrangularis L. prevents experimental hypertension induced in rats with nitric oxide deficits improving the endothelium vasodilatation response and protecting against vascular remodelling.

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Soy protein hydrolysate ameliorates cardiovascular remodeling in rats with l-NAME-induced hypertension

Cited by 33 publications

References 36 publications

Involvement of tumor necrosis factor-α in natriuretic response to systemic infusion of nitric oxide synthase inhibitor in anesthetized mice

Involvement of tumor necrosis factor-α in natriuretic response to systemic infusion of nitric oxide synthase inhibitor in anesthetized mice

β-Conglycinin Peptides Improve Glucose Uptake through the AMPK Signaling Pathway in L6 Myotubes

Passiflora quadrangularis L. PREVENTS EXPERIMENTAL HYPERTENSION AND VASCULAR REMODELLING IN RATS EXPOSED TO NITRIC OXIDE DEFICIT

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