Soy protein isolate/bioactive glass composite membranes: Processing and properties

Abstract

Composite biomaterials based on proteins and inorganic fillers are highly attractive for wound dressing applications due to their highly absorbent properties towards blood and exudate provided by the inorganic fillers. Moreover, such composites offer a desirable environment for cells due to the combination of organic and inorganic characteristics. This study highlights the fabrication of soy protein isolate/nanoscale bioactive glass composite films by solvent casting method as a matrix for wound-dressing applications. The effect of the addition of bioactive glass nano particles on blood clotting was assessed. Cytotoxicity and in vitro cytocompatibility of the films were also tested. The results showed that the composite films could meet the essential requirements for an appropriate wound dressing with additional favorable properties such as hemostatic capability and mechanical properties as well as significant cell cytocompatibility.

Soy Protein-Based Composite Hydrogels: Physico-Chemical Characterization and In Vitro Cytocompatibility

“…For instance, Ostomel et al [17] used silicate glasses as hemostasis-inducing materials for blood clot formation, demonstrating that Ca +2 ions releasing from BG can reinforce the coagulation cascade. Also in our previous study [18], the clotting assay on soy protein-BG nanoparticle composite films indicated a higher clotting rate for the composite films compared to the control. Silver-doped mesoporous BG-containing biopolymers induce antibacterial effects and are therefore an alternative choice for healing burn wounds [19].…”

Biodegradable polymers, current trends of research and their applications, a review

“…For medical purposes, Tansaz et al [59] investigated the fabrication of SP isolate/nanoscale bioactive glass composite films by solvent casting method as a matrix for wound-dressing applications. The effect of the addition of bioactive glass nanoparticles on blood clotting was assessed [59].…”

Advancement of Nanobiomaterials to Deliver Natural Compounds for Tissue Engineering Applications

“…The structural differences in protein can affect the physical and mechanical properties of the films [168]. A wound-dressing material prepared using soy-protein-based bioactive glass nanoparticles was tested on mouse embryonic fibroblast cells and showed excellent cell viability and cytocompatibility [169]. In another study, soy-protein-based bioactive glass nanofibrous scaffolds showed a significant advantage in their use in tissue engineering [170].…”