Soy isoflavones attenuate oxidative stress and improve parameters related to aging and Alzheimer’s disease in C57BL/6J mice treated with d-galactose

Hsieh, Huei-Min; Wu, Wen-Mein; Hu, Miao‐Lin

doi:10.1016/j.fct.2008.12.026

Cited by 173 publications

(120 citation statements)

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“…In 2009 Hsieh et al reported that soy isoflavones supplementation significantly and dose-dependently decreased the concentration of protein carbonyls in the liver, kidney and brain in D-galactose treated mice. Soy isoflavones administration effectively attenuate oxidative damage and improve parameters related to aging and Alzheimer's disease [99].…”

Section: Isoflavonesmentioning

confidence: 99%

Plant-Derived Agents with Anti-Glycation Activity

Odjakova¹,

Popova²,

Sharif³

et al. 2012

Glycosylation

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Section: Isoflavonesmentioning

confidence: 99%

Plant-Derived Agents with Anti-Glycation Activity

Odjakova¹,

Popova²,

Sharif³

et al. 2012

Glycosylation

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“…Lactose is hydrolyzed to monosaccharides glucose and galactose. However, excessive D -Gal undergoes abnormal conversion to galactitol, causing osmotic stress and generation of ROS (Kaplan and Pesce, 1996;Hsieh et al, 2009). …”

Section: Introductionmentioning

confidence: 99%

Improving Effect of Silk Peptides on the Cognitive Function of Rats with Aging Brain Facilitated by D-Galactose

Park¹,

Lee²,

Choi³

et al. 2011

Biomolecules and Therapeutics

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“…Chronic administration of D-galactose (DG) to BL/6J mice has been shown to induce changes which resemble accelerated ageing, such as formation of advanced glycation end products (2,3) , neurological impairment (4,5) , decreased serum antioxidative enzyme activities (4,5) and inflammation in the liver (3,6) . Several antioxidants (3,7,8) and Chinese herbs (9) have been shown to attenuate the ageing damage in C57BL/6J mice treated with DG.Fructo-oligosaccharide (FO), a well-defined prebiotic (10) , has been incorporated into drinks and desserts to improve bowel function in elderly persons (11) . Recent clinical studies have initially shown that the consumption of a prebiotic mix (12) and a FO supplement (13) beneficially reduces the blood indices of peroxidation status.…”

mentioning

confidence: 99%

Antioxidative and hepatoprotective effects of fructo-oligosaccharide ind-galactose-treated Balb/cJ mice

et al. 2010

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Chronic subcutaneous (s.c.) administration of D-galactose (DG) to BL/6J mice has been shown to induce oxidative stress and is considered a model to mimic accelerated ageing. Fructo-oligosaccharide (FO) is a well-defined prebiotic and its fermentation by lactic acid bacteria has been shown to exert antioxidative capacity. The present study was aimed to determine whether FO attenuated DG-induced oxidative stress and hepatopathy in Balb/cJ mice. Mice (12 weeks of age, n 40) were divided into control (s.c. saline), DG (s.c. 1·2 g/kg body weight), DG þ FO (5 %, w/w) and DG þ vitamin E (0·2 %, w/w) groups and were killed after 52 d of treatment. Results indicated that DG significantly decreased the hepatic superoxide dismutase and glutathione peroxidase activities. These alterations were ameliorated both by FO and vitamin E. DG increased the hepatic TAG content approximately by 7·2 % compared with the vehicle control, which was in agreement with the histological alteration. FO, similar to vitamin E, almost normalised the hepatic TAG content and ameliorated the histological characteristics of fatty liver. Similarly, the increased plasma alanine aminotransferase activity induced by DG was normalised by FO and vitamin E, respectively. Faecal bifidobacteria counts were greater in the DG þ FO and DG þ vitamin E groups compared with the DG group, respectively. In conclusion, the present study indicated that FO diminished the altered hepatic antioxidative enzyme activities and morphology caused by chronic DG administration in Balb/cJ mice, partially associated with its prebiotic role in the colon.Key words: D-Galactose: Fructo-oligosaccharide: Antioxidative capacity: Liver: Ageing One of the well-recognised ageing theories indicates that generation of oxidative stress leads to cell and tissue damage and ultimately results in ageing and cell death (1) . Chronic administration of D-galactose (DG) to BL/6J mice has been shown to induce changes which resemble accelerated ageing, such as formation of advanced glycation end products (2,3) , neurological impairment (4,5) , decreased serum antioxidative enzyme activities (4,5) and inflammation in the liver (3,6) . Several antioxidants (3,7,8) and Chinese herbs (9) have been shown to attenuate the ageing damage in C57BL/6J mice treated with DG.Fructo-oligosaccharide (FO), a well-defined prebiotic (10) , has been incorporated into drinks and desserts to improve bowel function in elderly persons (11) . Recent clinical studies have initially shown that the consumption of a prebiotic mix (12) and a FO supplement (13) beneficially reduces the blood indices of peroxidation status. However, the effect of FO in DG-induced hepatic oxidative damage has never been demonstrated.The main goal of the present study was to assess the anti-ageing and hepatoprotective effects of FO in DGadministered Balb/cJ mice, by the determination of antioxidative enzyme activities and the morphology of the liver and the biochemical indices of liver function. Materials and methods Animals and dietsMale B...

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Soy isoflavones attenuate oxidative stress and improve parameters related to aging and Alzheimer’s disease in C57BL/6J mice treated with d-galactose

Cited by 173 publications

References 44 publications

Plant-Derived Agents with Anti-Glycation Activity

Plant-Derived Agents with Anti-Glycation Activity

Improving Effect of Silk Peptides on the Cognitive Function of Rats with Aging Brain Facilitated by D-Galactose

Antioxidative and hepatoprotective effects of fructo-oligosaccharide ind-galactose-treated Balb/cJ mice

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