Soy isoflavones alleviate lipopolysaccharide-induced depressive-like behavior by suppressing neuroinflammation, mediating tryptophan metabolism and promoting synaptic plasticity

Lü, Cong; Wei, Zhen; Wang, Yongquan; Li, Shuying; Tong, Litao; Liu, Xinmin; Fan, Bin; Wang, Zhong Feng

doi:10.1039/d2fo01437h

Cited by 9 publications

(4 citation statements)

References 41 publications

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“…Specifically, researchers speculated that isoflavones and phytochemicals in these beans build the defense against osteoporosis. For instance, soy isoflavones as phytoestrogens exerted estrogen-like effect and were believed to decrease bone resorption marker urine deoxypyridinoline, inhibiting bone resorption and increasing lumbar spine BMD ( 49 , 50 ). Meanwhile, beans are a good source of plant protein and proteins intake is positively associated with BMD and negatively related with osteoporosis regardless of protein source ( 51 – 53 ).…”

Section: Discussionmentioning

confidence: 99%

Associations of healthy eating index-2015 with osteoporosis and low bone mass density in postmenopausal women: a population-based study from NHANES 2007–2018

Wang,

Wu,

Deng

et al. 2024

Front. Nutr.

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PurposeThe current study aimed to explore the associations of diet quality assessed by healthy eating index-2015 (HEI-2015) with risks of osteoporosis and low bone mineral density (BMD) among American postmenopausal women aged 50 years and older.MethodsPostmenopausal women aged 50 years and older in the National Health and Nutrition Examination Survey from 2007 through 2018 were included in the final sample. Analysis of variance and Rao-Scott adjusted chi-square tests were used to compare the characteristics across tertiles of HEI-2015. Univariate and multivariate weighted logistic regression models were employed to explore the associations of HEI-2015 tertiles and continuous HEI-2015 with the risks of osteoporosis and low BMD. Nonlinear dose-response associations were evaluated using weighted restricted cubic spline analyses, and the contributions of various HEI-2015 components were assessed using weighted quantile sum regression models.ResultsThe final sample included 3,421 postmenopausal women aged 50 years and older representative for approximately 28.38 million non-institutionalized U.S. postmenopausal women. Osteoporosis prevalence decreased with HEI-2015 tertiles while the prevalence of low BMD showed no significant decrease. Compared with postmenopausal women in the first tertile of HEI-2015, those with the second (OR: 0.57, 95%CI: 0.38–0.84) and third (OR: 0.48, 95%CI: 0.29–0.78) HEI-2015 tertiles were associated with reduced osteoporosis risk after multivariate adjustments, but no significant association of HEI-2015 with the risk of BMD was identified. Furthermore, similar effects were confirmed in the sensitivity analyses and subgroup analyses and interaction effects. Moreover, significant nonlinear associations were observed between HEI-2015 with osteoporosis risk, and total vegetables, refined grains and greens and beans demonstrated the strongest protective effect among HEI-2015 components against osteoporosis.ConclusionsThis study strongly suggests the significant negative associations of HEI-2015 with osteoporosis risk in American postmenopausal women. These findings highlight the importance of adherence to the dietary guidelines for Americans in reducing the risk of osteoporosis.

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Section: Discussionmentioning

confidence: 99%

Associations of healthy eating index-2015 with osteoporosis and low bone mass density in postmenopausal women: a population-based study from NHANES 2007–2018

Wang,

Wu,

Deng

et al. 2024

Front. Nutr.

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“…Recent research by Ying Yang suggests that the phytoestrogen Formononetin, which exhibits estrogen-like effects, can reverse the polarization of M1 microglia while promoting the polarization of M2 microglia [ 67 ]. Additionally, Soy isoflavones have been found to ameliorate depression-like behaviors by inhibiting hippocampal neuroinflammation and the toll-like receptor 4 (TLR4)/nuclear factor kappa B (NF-κB) signaling pathway [ 68 ]. These findings suggest that estrogen and its derivatives may have therapeutic potential in treating depression through their modulation of neuroinflammation.…”

Section: Estrogen and Depressionmentioning

confidence: 99%

Role of estrogen in treatment of female depression

Sun,

Li,

Zhao

et al. 2024

Aging

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Depression is a neurological disorder that profoundly affects human physical and mental health, resulting in various changes in the central nervous system. Despite several prominent hypotheses, such as the monoaminergic theory, hypothalamic-pituitary-adrenal (HPA) axis theory, neuroinflammation, and neuroplasticity, the current understanding of depression’s pathogenesis remains incomplete. Importantly, depression is a gender-dimorphic disorder, with women exhibiting higher incidence rates than men. Given estrogen's pivotal role in the menstrual cycle, it is reasonable to postulate that its fluctuating levels could contribute to the pathogenesis of depression. Estrogen acts by binding to a diversity of receptors, which are widely distributed in the central nervous system. An abundance of research has established that estrogen and its receptors play a crucial role in depression, spanning pathogenesis and treatment. In this comprehensive review, we provide an in-depth analysis of the fundamental role of estrogen and its receptors in depression, with a focus on neuroinflammation, neuroendocrinology, and neuroplasticity. Furthermore, we discuss potential mechanisms underlying the therapeutic effects of estrogen in the treatment of depression, which may pave the way for new antidepressant drug development and alternative treatment options.

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“…Bununla birlikte reboksetin'in SSS'de diyabet ile indüklenen moleküler düzeydeki bozuklukları restore etmiş olması da mümkün olabilir. Nitekim reboksetin'in de üyesi olduğu antidepresan ilaçların diyabetik deneklerin beyinlerindeki yetersiz LTP indüksiyonunu, azalan sinaptik protein seviyelerini (sinaptofizin, postsinaptik yoğunluk 95 gibi) ve zayıflayan sinaptik gücü [75,76] iyileştirme potansiyeline sahip oldukları bilinmektedir [73,[77][78][79]. Bu düşünceyi destekler nitlikte olmak üzere; araştırma grubumuz tarafından daha önce yapılan bir çalışmada antidepresan bir ilaç olan agomelatin'in (40 ve 80 mg/kg, 2 hafta) STZ-diyabetik sıçanların öğrenme ve bellek performanslarında kayda değer bir iyileşme sağladığı ve bu hayvanların beyinlerinde hipokampal alt alanlardaki nöron kayıplarını önlediği gösterilmiştir [80].…”

Section: Morris Su Tankı Testine İlişkin Bulgularunclassified

Rebokseti̇n’i̇n Di̇yabeti̇k Siçanlarda Bozulmuş Davraniş Parametreleri̇ Üzeri̇ndeki̇ Yararli Etki̇leri̇

Yücel

Kandemir

Üçel

et al. 2022

Ankara Ecz. Fak. Derg.

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Amaç: Diyabetik hastalarda duygu-durum hastalıklarının ve kognitif bozukluk insidansının genel popülasyona oranla daha yüksek olduğu bilinmektedir. Bu çalışmada, klinikte antidepresan etkinliği için reçete edilen reboksetin’in sıçanlarda diyabet ile indüklenen davranışsal ve bilişsel değişiklikler üzerine etkinliğinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Sıçanlarda deneysel diyabet modeli 50 mg/kg tek doz streptozotosin enjeksiyonu (i.v.) ile oluşturulnuştur. Reboksetin tedavisine diyabetik komplikasyonların oluşması için 4 hafta beklendikten sonra başlanmıştır. Deney hayvanlarının depresyon ve anksiyete düzeyleri sırasıyla modifiye zorlu yüzme ve yükseltilmiş artı şekilli labirent testleri ile araştırılmış; kognitif performansları ise Morris su tankı ve pasif sakınma testleri ie değerlendirilmiştir. Hayvanlarının motor aktiviteleri de aktivite kafesi ve Rota-rod testleri ile incelenmiştir. Sonuç ve Tartışma: Deneyler sonucunda, diyabetik sıçanların depresyon ve anksiyete düzeylerinin yükseldiği ve bilişsel performanslarının zayıfladığı belirlenmiştir. İki hafta süre ile uygulanan reboksetin tedavisi (8 ve 16 mg/kg) diyabetik sıçanların yüksek depresyon ve anksiyete düzeylerini azaltırken, zayıflamış olan bilişsel performanslarını kayda değer ölçüde güçlendirmiştir. Elde edilen bulgular reboksetin’in diyabete bağlı olarak ortaya çıkan davranışsal ve bilişsel bozuklukların tedavisinde terapötik bir potansiyele sahip olabileceğine işaret etmiştir.

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Soy isoflavones alleviate lipopolysaccharide-induced depressive-like behavior by suppressing neuroinflammation, mediating tryptophan metabolism and promoting synaptic plasticity

Abstract: Depression is highly prevalent in patients suffering from chronic inflammatory diseases. Dysregulated neuroinflammation and concomitant activated microglia play a pivotal role in the pathogenesis of depression. As an important functional...

Cited by 9 publications

References 41 publications

Associations of healthy eating index-2015 with osteoporosis and low bone mass density in postmenopausal women: a population-based study from NHANES 2007–2018

Associations of healthy eating index-2015 with osteoporosis and low bone mass density in postmenopausal women: a population-based study from NHANES 2007–2018

Role of estrogen in treatment of female depression

Rebokseti̇n’i̇n Di̇yabeti̇k Siçanlarda Bozulmuş Davraniş Parametreleri̇ Üzeri̇ndeki̇ Yararli Etki̇leri̇

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