SOX11 hypermethylation as a tumor biomarker in endometrial cancer

Shan, Tianjiao; Uyar, Denise; Wang, Li Shu; Mutch, David G.; Huang, Tim Hui-Ming; Rader, Janet S.; Sheng, Xiugui; Huang, Yi Wen

doi:10.1016/j.biochi.2019.03.019

Cited by 15 publications

(10 citation statements)

References 26 publications

(47 reference statements)

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“…It has been demonstrated that SOX11 is overexpressed in endometrial cancer and mantle cell lymphoma ( 23 , 24 ). In the present study, SOX11 was also upregulated in pancreatic carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Long non‑coding RNA TMPO‑AS1 serves as a tumor promoter in pancreatic carcinoma by regulating miR‑383‑5p/SOX11

et al. 2021

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The dysregulation of lncRNA TMPO antisense RNA 1 (TMPO-AS1) has been detected in various malignant tumors. However, the role of lncRNA TMPO-AS1 remains unclear in pancreatic carcinoma. The present study aimed to elucidate the functional mechanism of TMPO-AS1 in pancreatic carcinoma. In the present study, RT-qPCR, western blotting, MTT, Transwell, luciferase reporter and xenograft assays were used to investigate the role of lncRNA TMPO-AS1 in pancreatic carcinoma. Upregulation of lncRNA TMPO-AS1 was revealed in pancreatic carcinoma tissues and cells. Furthermore, knockdown of TMPO-AS1 restrained cell proliferation and motility in pancreatic carcinoma. In addition, microRNA (miR)-383-5p acted as a ‘sponge’ for lncRNA TMPO-AS1. The expression levels of lncRNA TMPO-AS1 and miR-383-5p were mutually inhibited in pancreatic carcinoma. Moreover, miR-383-5p was revealed to directly target SRY-related high-mobility group box 11 (SOX11). Notably, SOX11 could promote the occurrence of pancreatic carcinoma by interacting with the lncRNA TMPO-AS1/miR-383-5p axis. In conclusion, upregulation of lncRNA TMPO-AS1 promoted tumor growth, cell migration and invasion in pancreatic carcinoma by downregulating miR-383-5p and upregulating SOX11.

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“…It has been demonstrated that SOX11 is overexpressed in endometrial cancer and mantle cell lymphoma ( 23 , 24 ). In the present study, SOX11 was also upregulated in pancreatic carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Long non‑coding RNA TMPO‑AS1 serves as a tumor promoter in pancreatic carcinoma by regulating miR‑383‑5p/SOX11

et al. 2021

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“…The two lncRNAs ltered in multi-Cox regression analysis in CPTAC, TRBV11-2 and MEG8 provided potential pathways to explain ceRNA regulatory network despite of none associated reports for UCEC. Firstly, they could up-regulate SOX11 expression by binding to hsa-mir-363 to bring about poor prognosis, and survival related mRNA SOX11 hypermethylation was reported as a tumor biomarker in UCEC [43].…”

Section: Discussionmentioning

confidence: 99%

Identification of the Prognostic LncRNA Biomarkers and Comprehensive Analysis of LncRNA-Mediated ceRNA Network for Uterine Corpus Endometrial Carcinoma

Cai

Cui

2021

Preprint

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Background Given that long non-coding RNAs (lncRNAs) involved in the tumor initiation or progression of the endometrium and that competing endogenous RNA (ceRNA) plays an important role in increasingly more biological processes, lncRNA-mediated ceRNA is likely to function in the pathogenesis of uterine corpus endometrial carcinoma (UCEC). Our present study aimed to explore the potential molecular mechanisms for the prognosis of UCEC through an lncRNA-mediated ceRNA network. Methods The transcriptome profiles and corresponding clinical profiles of UCEC dataset were retrieved from CPTAC and TCGA databases respectively. Differentially expressed genes (DEGs) in UCEC samples were identified via “Edge R” package. Then, an integrated bioinformatics analysis including functional enrichment analysis, tumor infiltrating immune cell(TIIC) analysis, Kaplan-Meier curve, Cox regression analysis were conducted to analyze the prognostic biomarkers. Results In the CPTAC dataset of UCEC, a ceRNA network comprised of 36 miRNAs, 123 lncRNAs and 124 targeted mRNAs was established, and 8 of 123 prognostic-related DElncRNAs(Differentially Expressed long noncoding RNA) were identified. While in the TCGA dataset, a ceRNA network comprised of 38 miRNAs, 83 lncRNAs and 110 targeted mRNAs was established, and 2 of 83 prognostic-related DElncRNAs were identified. After filtered by risk grouping and Cox regression analysis, 10 prognostic-related lncRNAs including LINC00443, LINC00483, C2orf48, TRBV11-2, MEG-8 were identified. In addition, 33 survival-related DEmRNAs(Differentially Expressed messager RNA) in two ceRNA networks were further validated in the HPA database. Finally, six lncRNA/miRNA/mRNA axes were established to elucidate prognostic regulatory roles in UCEC. Conclusion Several prognostic lncRNAs are identified and prognostic model of lncRNA-mediated ceRNA network is constructed, which promotes the understanding of UCEC development mechanisms and potential therapeutic targets.

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“…[127][128][129][130] Remarkably, in the absence of hMLH1 mutations, hypermethylation of CGI 5 0 of hMLH1 can cause gene repression that leads to microsatellite instability. [131][132][133] This highlights the impact of epigenetic silencing events as an alternative to genetic mutations and exemplifies the widespread effects of promoter hypermethylation. DNA methylation changes in CRC may also derail gene control networks, as evident through loss of imprinting at the IGF2 gene.…”

Section: Dna Hypomethylation and Hypermethylation In Colorectal Cancermentioning

confidence: 94%

Epigenetic Regulation of Intestinal Stem Cells and Disease: A Balancing Act of DNA and Histone Methylation

et al. 2021

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Genetic mutations or regulatory failures underlie cellular malfunction in many diseases, including colorectal cancer and inflammatory bowel diseases. However, mutational defects alone fail to explain the complexity of such disorders. Epigenetic regulation-control of gene action through chemical and structural changes of chromatin-provides a platform to integrate multiple extracellular inputs and prepares the cellular genome for appropriate gene expression responses. Coregulation by polycomb repressive complex 2-mediated trimethylation of lysine 27 on histone 3 and DNA methylation has emerged as one of the most influential epigenetic controls in colorectal cancer and many other diseases, but molecular details remain inadequate. Here we review the molecular interplay of these epigenetic features in relation to gastrointestinal development, homeostasis, and disease biology. We discuss other epigenetic mechanisms pertinent to the balance of trimethylation of lysine 27 on histone 3 and DNA methylation and their actions in gastrointestinal cancers. We also review the current molecular understanding of chromatin control in the pathogenesis of inflammatory bowel diseases.

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SOX11 hypermethylation as a tumor biomarker in endometrial cancer

Cited by 15 publications

References 26 publications

Long non‑coding RNA TMPO‑AS1 serves as a tumor promoter in pancreatic carcinoma by regulating miR‑383‑5p/SOX11

Long non‑coding RNA TMPO‑AS1 serves as a tumor promoter in pancreatic carcinoma by regulating miR‑383‑5p/SOX11

Identification of the Prognostic LncRNA Biomarkers and Comprehensive Analysis of LncRNA-Mediated ceRNA Network for Uterine Corpus Endometrial Carcinoma

Epigenetic Regulation of Intestinal Stem Cells and Disease: A Balancing Act of DNA and Histone Methylation

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