South East Asia, Differing Socioeconomic Factors, Differing Access to Radiotherapy: The Philippines, a Microcosm

Calaguas, M.J.; Gubat, Johannes

doi:10.1016/j.semradonc.2016.11.010

Cited by 10 publications

(10 citation statements)

References 6 publications

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“…The majority of the subjects were untreated patients with locally advanced cervical cancer, a primary school education, economic problems, who were unemployed. Referring to the situation reported in 2017, more than 50% of patients did not receive radiotherapy as indicated in Mainland China, and only 6 of 11 countries in Southeast Asia had facilities to treat cervical cancer (Wang et al, 2017;Calaguas and Gubat 2017). Thus, a number of patients had no access to treatment.…”

Section: Study Included 400mentioning

confidence: 99%

Validation of the Functional Assessment of Cancer Therapy with Cervical Cancer Subscale (FACT-CX) for Quality of Life in Thai Patients Prior to Chemoradiotherapy

Peerawong

Suphasynth

Kongkamol

et al. 2020

Asian Pac J Cancer Prev

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Objective: Cervical cancer is the second most common cancer in Thailand. For cervical cancer, there is no cancer specific quality of life questionnaire. This study aims to develop and validate Thai FACT-CX. Methods: The cross-sectional study included all women aged ≥18 years with stage IB2-IIIB who planned to undergo chemoradiotherapy. Those who did not understand Thai language, had other cancers (except for skin cancer), were diagnosed with impaired cognition and/or overt psychosis, and major depression were excluded. The FACT-CX comprises 42 items with 5 domains and a score range of 0-168. The WHOQOL-BREF comprises 26 items with 4 domains and a score range of 26-130. The participants were interviewed about demographic and clinical data. Both questionnaires were self-completed. Factor analysis was used to compare our data with the previous structure. The reliability used Cronbach’s alpha. Spearman’s correlation determined relationship between the domains of the modified FACT-CX and WHOQOL-BREF. Both questionnaires were compared with socioeconomic and clinical variables using the Ranksum test and Kruskal-Wallis test. P-value > 0.05 considered significant. Results: The 245 participants included. Expletory factor analysis revealed an accumulative variance of 0.42 with 4 factors. The internal consistency was 0.84, 0.81, 0.78, 0.77 and 0.90 for perception of self, suffering symptoms, family support, life resilience and total questions. There was correlation between the domains of the modified FACT-CX and WHOQOL-BREF. Both the modified FACT-CX and WHOQOL-BREF could identify differences between the groups of patients. Conclusion: Finally, the Thai modified FACT-CX was found to be reliable and valid for measuring quality of life among untreated cervical cancer patients.

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Section: Study Included 400mentioning

confidence: 99%

Validation of the Functional Assessment of Cancer Therapy with Cervical Cancer Subscale (FACT-CX) for Quality of Life in Thai Patients Prior to Chemoradiotherapy

Peerawong

Suphasynth

Kongkamol

et al. 2020

Asian Pac J Cancer Prev

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“…Patients who live in remote areas tend to refuse to undergo therapy due to the limitation of transportation and lodging costs and duration of therapy that interferes with work schedules [ 9 , 10 ]. Challenging geographical and the range to the facility for such patient who lived in rural areas especially who have lower incomes [ 11 ]. Patients with higher levels of education and working hours tend to be more likely to accept adjuvant chemotherapy plans that increase their expectancy and quality of life.…”

Section: Discussionmentioning

confidence: 99%

Treatment acceptance and its associated determinants in cancer patients: A systematic review

Novirianthy,

Syukri,

Gondhowiardjo

et al. 2023

Narra J

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Treatment recommendations for cancer patients are carried out according to clinical assessment, type and stage of cancer and treatment guidelines. However, many patients do not accept the recommendations. This raises obstacles in managing of cancers, which not only affects the patients, but also the family and people around the patients. This problem could increase morbidity, mortality and recurrence rate, which might result in lower quality of life. Since this condition is a complex problem, there is necessity to explore and determine various determinants from different levels. The aim of this systematic review was to explore the acceptances of cancer treatments among cancer patients and its associated determinants. Articles published from 2010 to 2023 were searched in four databases: ScienceDirect, Medline, Google Scholar and PubMed. Articles written in English and focussing on three main cancer treatments (surgery, chemotherapy and radiotherapy) were eligible. A narrative approach was used and the data were analysed into selected themes. Data suggest that several factors influence patient acceptance for cancer therapy including sociodemographic, economic and spiritual cultural backgrounds; patient knowledge and perceptions; community support, as well as policy and availability of health facilities. The determinants consist of individual, interpersonal, institutional, community and public policy level and interaction between levels are contributing to cancer treatment acceptance. In conclusion, cancer treatment acceptance remains a problem in particular in low middle income countries. In addition, the data on radiotherapy referral acceptance were limited and needed further study.

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“…[29][30][31] Duen ˜as-Gonza ´lez et al reported significant improvement in PFS and OS among those who received CCRT plus ACT compared with those who received CCRT monotherapy. 29 However, the application of ACT is limited by several social and economic problems in developing countries, 32 including longer overall treatment duration and higher costs of treatment. In the present study, treatment durations were extended by only 1 to 2 weeks, and additional medical costs were not high because only prophylactic PALN-RT was conducted instead of radical CCRT.…”

Section: Discussionmentioning

confidence: 99%

Multi-institutional Observational Study of Prophylactic Extended-Field Concurrent Chemoradiation Therapy Using Weekly Cisplatin for Patients With Pelvic Node-Positive Cervical Cancer in East and Southeast Asia

Wakatsuki

Kato

Ohno

et al. 2019

International Journal of Radiation Oncology*Biology*Physics

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Uterine cervical cancer is among the most common cancers in East and Southeast Asia, and it is necessary to develop new treatment methods suitable for developing countries. This multiinstitutional observational study conducted among 11 East and Southeast Asian countries aimed to evaluate the clinical outcomes of prophylactic extended-field concurrent chemoradiation therapy with locally advanced cervical cancer. The results indicated that extended-field concurrent chemoradiation therapy is feasible and effective for locally advanced cervical cancer in developing countries.Purpose: This multi-institutional observational study conducted among 11 countries in East and Southeast Asia aimed to assess the clinical outcomes of prophylactic extended-field concurrent chemoradiation therapy using weekly cisplatin for patients with locally advanced cervical cancer. Methods and Materials: Between October 2007 and May 2016, 106 patients with untreated squamous cell carcinoma of the cervix were enrolled in the present study. Radiation therapy consisted of pelvic irradiation (total dose, 50 Gy in 25 fractions including central shielding), prophylactic paraortic regional irradiation (36-40 Gy in 20 fractions), and either high-or low-dose-rate intracavitary brachytherapy (ICBT) according to institutional practice. The planned point A dose was 21 to 28 Gy in 3 to 4 fractions for high-dose-rate ICBT and 40 to 41 Gy in 1 to 2 fractions for low-dose-rate ICBT. Five cycles of weekly cisplatin (40 mg/m 2 ) were administered during the radiation therapy course. Results: A total of 106 patients were enrolled. Of these, 9 had major protocol violations and 2 did not receive treatment because of worsened general condition. Thus, 95 patients were evaluable. The median follow-up was 56 months. Of the 95 patients, 76 (80%) received 4 or 5 cycles of chemotherapy. Acute grade 3 leukopenia was observed in 20 of the patients (21%), and late grade 3 gastrointestinal toxicity was observed in 3%. The 2-year local control, progression-free survival, and overall survival rate for all patients were 96%, 78%, and 90%, respectively. Conclusions: The results indicated that prophylactic extended-field concurrent chemoradiation therapy using weekly cisplatin is feasible and effective for patients with locally advanced cervical cancer in East and Southeast Asia.

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South East Asia, Differing Socioeconomic Factors, Differing Access to Radiotherapy: The Philippines, a Microcosm

Cited by 10 publications

References 6 publications

Validation of the Functional Assessment of Cancer Therapy with Cervical Cancer Subscale (FACT-CX) for Quality of Life in Thai Patients Prior to Chemoradiotherapy

Validation of the Functional Assessment of Cancer Therapy with Cervical Cancer Subscale (FACT-CX) for Quality of Life in Thai Patients Prior to Chemoradiotherapy

Treatment acceptance and its associated determinants in cancer patients: A systematic review

Multi-institutional Observational Study of Prophylactic Extended-Field Concurrent Chemoradiation Therapy Using Weekly Cisplatin for Patients With Pelvic Node-Positive Cervical Cancer in East and Southeast Asia

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