Validation of the Functional Assessment of Cancer Therapy with Cervical Cancer Subscale (FACT-CX) for Quality of Life in Thai Patients Prior to Chemoradiotherapy

Peerawong, Thanarpan; Suphasynth, Yuthasak; Kongkamol, Chanon; Rordlamool, Paytai; Bridhikitti, Jidapa; Jiratrachu, Rungarun; Sangtawan, Duangjai; Atjimakul, Thiti; Chicharoen, Saibua

doi:10.31557/apjcp.2020.21.7.1891

Cited by 4 publications

(3 citation statements)

References 10 publications

(14 reference statements)

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“…Our study found that patients with cervical precursor lesions and cancer aged 40-59 years had the lowest HRQoL utility and VAS scores. This result was consistent with studies in Korea [23] and Thailand [24]. Previous research indicates that incidence of cervical cancer is highest in those aged 40-59 years [17].…”

Section: Discussionsupporting

confidence: 93%

“…Our ndings indicate that low household income is associated with lower HRQoL utility scores, a nding consistent with study results in Thailand [24]. This association of household income with HRQoL of patients with cervical precursor lesions and cancer suggests wealthier patients may be more conscious about and able to spend money to promote their health.…”

Section: Discussionsupporting

confidence: 90%

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Health-Related Quality of Life with Cervical Cancer and Precancer: A Cross-Sectional Study in Yunnan Province, China

Min

Zhang

et al. 2021

Preprint

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Objectives Cervical cancer is the fourth most common cancer in women, with an estimated 600,000 new cases and 340,000 deaths worldwide in 2020. However, there remains limited understanding of the association between individual socioeconomic status (SES) and clinical characteristics and health-related quality of life (HRQoL) of women with cervical precancerous lesions and cancer worldwide, including in China. This study investigates socioeconomic and clinical variations in HRQoL of women with cervical precancerous lesions and cancer in Yunnan Province, China.MethodsThe present study employed a cross-sectional survey design. An EQ-5D-5L questionnaire was used to assess HRQoL of 400 patients with cervical precancerous lesions and cancer in Yunnan Province, China from 2019 to 2020. ANOVA and independent samples t-tests were performed to identify the independent variables associated with the EQ-5D-5L utility scores and VAS scores. Predictors of the utility scores were confirmed using a Tobit regression model.ResultsThe mean of cervical precancerous lesions and cancer patients’ EQ-5D-5L utility scores was 0.939 (SD, 0.104) and the mean of VAS scores was 80.84(SD, 16.551). Patients aged 40-59 years (β=-0.037, p=0.005), patients who were not aware of the human papillomavirus (HPV) vaccine (β=-0.032, p=0.004), and patients who underwent radical hysterectomy (β=-0.036, p=0.006) had significantly lower utility scores, whereas having high monthly household income (β=0.023, p=0.033) was significantly associated with higher EQ-5D-5L utility scores. Age (p=0.023) was statistically significant in differences in patients’ VAS scores. Anxiety/depression was the most frequently reported issue (35.75%) among participants. ConclusionsFuture cervical cancer prevention and treatment guidelines should focus on low-income women, women aged 40-59 years, and those lacking knowledge about cervical cancer prevention.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 90%

Health-Related Quality of Life with Cervical Cancer and Precancer: A Cross-Sectional Study in Yunnan Province, China

Min

Zhang

et al. 2021

Preprint

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“…The side effects of long-term radiotherapy and multi cycle chemotherapy bring great pain and psychological trauma to patients [ 25 ]. Moreover, during waiting for radiotherapy, fear and misunderstanding of radiotherapy will cause anxiety, which causing physical symptoms and emotional distress will affect the health-related quality of life of patients [ 26 ]. The health-related quality of life of younger patients is also better than that of older patients, which may be related to the better physical function of younger patients [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Healthy-related quality of life in patients with cervical cancer in Southwest China: a cross-sectional study

Zhao

Luo

zhang

et al. 2021

BMC Health Serv Res

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Background Cervical cancer is the second most common female malignant tumor in the world. According to a study in 2018, the incidence of cervical cancer in Yunnan Province of China was 11.42 per 100,000, the mortality rate was 3.77 per 100,000, and higher than the national average. Health-related quality of life (HRQoL) can be used not only in the selection and effect evaluation of clinical treatment plans of cervical cancer, but also in the evaluation of prognosis and long-term survival status. In this study, 288 cervical cancer patients admitted to the Yunnan Cancer Hospital in Southwest China from 2018 to 2020 were used as the survey objects to understand the HRQoL of cervical cancer patients and explore the related factors that affect HRQoL. Methods The Chinese version of the functional assessment of cancer therapy-cervix (functional assessment of cancer therapy-cervix v4.0, FACT-Cx V4) was used to investigate 288 patients with cervical cancer in Yunnan Province. Statistical analysis was performed using t-test, analysis of variance, multiple linear regression and other methods. Results The total FACT-Cx score of cervical cancer patients was (130.16 ± 14.20), the physical well-being (PWB) score was (22.02 ± 4.47), the social/family well-being (SWB) score was (25.66 ± 3.59), the emotional well-being (EWB) score was (19.75 ± 3.54), the functional well-being (FWB) score was (16.91 ± 5.01) and the additional focus area (cervical cancer subscale, CxS) score was (45.78 ± 4.61). From the multi-factor analysis results, the scores of PWB, FWB, Cxs and the total FACT-Cx were related to the choice of different treatment methods, the PWB scores of patients with concurrent chemoradiotherapy was low(β = − 1.67, P = 0.003), the FWB scores of patients with concurrent chemoradiotherapy was low(β = − 2.02, P = 0.001), the CxS scores of patients with concurrent chemoradiotherapy was low(β = − 1.61, P = 0.006), the total score of FACT-Cx of patients with concurrent chemoradiotherapy was low(β = − 5.91, P = 0.001). SWB score was affected by marital status, married patients had high PWB scores(β = 5.44, P = 0.006). The patients with heavy disease expenditures as aproportion of family disposable income(β = − 3.82, P = 0.002) and aged 60 and above(β = − 3.29, P = 0.003) had lower FWB scores. The total score FACT-Cx of patients participating in cervical cancer screening was higher(β = 7.61, P = 0.001). Conclusion The choice of treatment method is the common influencing factor of PWB, FWB, Cxs and the total FACT-Cx. Disease expenditures as a proportion of family disposable income, the treatment method, the marital status and whether to participate in cervical cancer screening affect the patient’s evaluation of their own HRQoL. Medical staff should pay special attention to the choice of different treatment methods, popularize vaccination knowledge and cervical cancer screening, give more humanistic care and health education to cervical cancer patients who have low education level, poor economic conditions, divorced or separated, and encourage patients to participate in active treatment to improve the health-related quality of life.

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Quality of life in patients with cervical cancer between the Han nationality and ethnic minorities in the Yunnan Province of China

Zhao

et al. 2023

BMC Women's Health

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Background Cervical cancer is the fourth most diagnosed cancer and the leading cause of cancer death, and it still poses a crippling threat to women’s health. China launched the National Cervical Cancer Screening Program for Rural Women in 2009, and an increasing number of cervical cancer patients have been detected. Health-related quality of life is not only the end point of cancer research but is also related to socioeconomic and clinical factors and has received an increasing amount of attention. In light of the characteristics of the Yunnan nationality, we conducted cross-sectional research to assess and explore the health-related quality of life in both Han and ethnic minority patients. Methods A cross-sectional study was conducted from January 2020 to May 2021 at the Third Affiliated Hospital of Kunming University/Yunnan Cancer Hospital. Patients, including 100 Han patients and 100 ethnic minorities, were interviewed using the FACT-Cx questionnaire within 3 months of receiving treatment. Results Patients of Han ethnicity and ethnic minorities were comparable in both sociodemographic and clinical features. The total FACT-Cx scores were 139.38 ± 9.83 and 134.39 ± 13.63 in Han and ethnic minority patients, respectively (P < 0.05). Significant differences were shown in physical well-being, emotional well-being and the FACT-Cx subscale between the Han and ethnic minority groups. Independent predictors of the FACT-Cx scale were ethnicity, educational level, participation in the National Cervical Cancer Screening Program for Rural Areas (NCCSPRA) and clinical stage. Conclusions The results of our study imply that the HRQOL of Han patients is better than that of ethnic minority patients. Thus, clinicians and related health workers should pay more attention to the HRQOL of cervical cancer patients, especially for ethnic minority patients, and provide psychosocial interventions as much as possible to improve their HRQOL. Policies should also aim to strengthen health education regarding cervical cancer and expand the coverage of the NCCSPRA among those who are ethnic minorities, are older and have low educational levels.

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Validation of the Functional Assessment of Cancer Therapy with Cervical Cancer Subscale (FACT-CX) for Quality of Life in Thai Patients Prior to Chemoradiotherapy

Cited by 4 publications

References 10 publications

Health-Related Quality of Life with Cervical Cancer and Precancer: A Cross-Sectional Study in Yunnan Province, China

Health-Related Quality of Life with Cervical Cancer and Precancer: A Cross-Sectional Study in Yunnan Province, China

Healthy-related quality of life in patients with cervical cancer in Southwest China: a cross-sectional study

Quality of life in patients with cervical cancer between the Han nationality and ethnic minorities in the Yunnan Province of China

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