South American cutaneous Leishmaniasis of the eyelids

Oliveira-Neto, Manoel P.; Martins, Vanessa J; Mattos, Marise; Pirmez, Claude; Brahin, Lucia R; Benchimol, Eliezer Israel

doi:10.1016/s0161-6420(99)00011-1

Cited by 23 publications

(7 citation statements)

References 10 publications

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“…It initially exhibits as highly polymorphous lesions, such as swelling [ 13 ], papules, and plaques [ 14 ]. A few cases of eyelids CL, which presented nodules covered by crusts and scaling, have been reported [ 15 , 16 ]. They can imitate other conditions, such as chalazion [ 4 , 5 ], hordeolum [ 5 , 6 ], infundibular cyst [ 17 ], and tumors which masquerading as basal cell carcinoma or keratoacanthoma in elderly patients [ 15 , 16 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Leishmaniasis of the Eyelids: A Case Series with Molecular Identification and Literature Review

et al. 2016

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Cutaneous leishmaniasis (CL) is a protozoan disease which is endemic in Iran. It is transmitted by the Phlebotomus sand fly. The eyelid is rarely involved possibly because the movement of the lids impedes the sand fly from biting the skin in this region. Here, we report 6 rare cases of eyelid CL. The patients were diagnosed by skin scraping, culture, and PCR from the lesions. Skin scraping examination showed Leishmania spp. amastigotes in the cytoplasm of macrophages. Culture examination was positive for Leishmania spp. PCR was positive for Leishmania major and Leishmania tropica. The lesions were disguised as basal cell carcinoma, chalazion, hordeolum, and impetigo. The patients were treated with intramuscular meglumine antimoniate (20 mg/kg/day) for at least 3 weeks. They showed a dramatic response, and the lesions almost completely disappeared. We emphasized the importance of clinical and diagnostic features of lesions, characterized the phylogenetic relationship of isolated parasites, and reviewed the literature on ocular leishmaniasis.

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Section: Discussionmentioning

confidence: 99%

Cutaneous Leishmaniasis of the Eyelids: A Case Series with Molecular Identification and Literature Review

et al. 2016

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“…Although the occurrence of ocular leishmaniasis is rare-2 to 5% of cases of cutaneous leishmaniasis in humans (Satici et al 2004)-possible complications resulting from injuries in the eye have been described (Oliveira-Neto et al 2000).…”

Section: Discussionmentioning

confidence: 99%

“…This manifestation is given by the parasite ability to colonize the anterior region of the eye (Puchol and Gonzalez 1989) and has been described in canine and human leishmaniasis (Oliveira-Neto et al 2000;Ciaramella et al 1997). According to Peña et al (2000), ocular manifestations occur in approximately 25% of canine leishmaniasis.…”

Section: Introductionmentioning

confidence: 99%

Infection of retinal epithelial cells with L. amazonensis impacts in extracellular matrix proteins

et al. 2011

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One of the manifestations of leishmaniases is eye injuries which main characteristics are the injury of the anterior chamber of the eye and the resistance to specific treatments. The retinal pigment epithelial (RPE) cells participate in pathogen-induced intraocular inflammatory processes. We investigated Leishmania amazonensis-RPE cells relationship and its impact in laminin and fibronectin production. Using RPE cell (ARPE-19), we demonstrated that L. amazonensis adhere to these cells in the first hour of infection, whereas parasite internalization was only observed after 6 h. Seventy-two hours after infection, vacuoles with parasites debris were observed intracellularly, and no parasite were observed intra- or extracellularly at the 96 h, suggesting that Leishmania can infect ARPE-19 cells although this cells are able to clear the infection. Fibronectin and laminin were associated with L. amazonensis-ARPE-19 interaction. Confocal analysis showed no substantial alterations in fibronectin presence in ARPE-19-infected or ARPE-19-noninfected cells, whereas laminin levels increased three times 10 h after L. amazonensis infection. After this time, laminin levels decreased in infected cells. These results suggest that L. amazonensis-ARPE-19 infection induces increased production of laminin in the beginning of infection which may facilitate parasite-host cell interactions.

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“…The differential diagnosis of eyelid leishmaniasis includes cysts, chalazion, basal cell carcinoma, tuberculosis, syphilis, and sarcoidosis. [7881] Ocular manifestations include ptosis, lagophthalmos, lower eyelid ectropion, lacrimal discharge, ulcerative blepharitis, blepharoconjunctivitis, nodular episcleritis, scleromalacia, ulcerative interstitial keratitis, anterior uveitis, and macular hemorrhage. Biswas et al .…”

Section: Leishmaniasismentioning

confidence: 99%

Update on pathology of ocular parasitic disease

Das

Ramachandra

Islam

et al. 2016

Indian J Ophthalmol

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Parasites are a group of eukaryotic organisms that may be free-living or form a symbiotic or parasitic relationship with the hosts. Consisting of over 800,000 recognized species, parasites may be unicellular (Protozoa) or multicellular (helminths and arthropods). The association of parasites with human population started long before the emergence of civilization. Parasitic zoonotic diseases are prevalent worldwide including India. Appropriate epidemiological data are lacking on existing zoonotic parasitic diseases, and newer diseases are emerging in our scenario. Systemic diseases such as cysticercosis, paragonimiasis, hydatidosis, and toxoplasmosis are fairly common. Acquired Toxoplasma infections are rising in immune-deficient individuals. Amongst the ocular parasitic diseases, various protozoas such as Cystoidea, trematodes, tissue flagellates, sporozoas etc. affect humans in general and eyes in particular, in different parts of the world. These zoonoses seem to be a real health related problem globally. Recent intensification of research throughout the world has led to specialization in biological fields, creating a conducive situation for researchers interested in this subject. The basics of parasitology lie in morphology, pathology, and with recent updates in molecular parasitology, the scope has extended further. The current review is to address the recent update in ophthalmic parasites with special reference to pathology and give a glimpse of further research in this field.

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South American cutaneous Leishmaniasis of the eyelids

Cited by 23 publications

References 10 publications

Cutaneous Leishmaniasis of the Eyelids: A Case Series with Molecular Identification and Literature Review

Cutaneous Leishmaniasis of the Eyelids: A Case Series with Molecular Identification and Literature Review

Infection of retinal epithelial cells with L. amazonensis impacts in extracellular matrix proteins

Update on pathology of ocular parasitic disease

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