Sound lateralisation in patients with left or right cerebral hemispheric lesions: relation with unilateral visuospatial neglect

Abstract

Objectives-To localise the brain lesion that causes disturbances of sound lateralisation and to examine the correlation between such deficit and unilateral visuospatial neglect. Method-There were 29 patients with right brain damage, 15 patients with left brain damage, and 22 healthy controls, who had normal auditory and binaural thresholds. A device was used that delivered sound to the left and right ears with an interaural time diVerence using headphones. The amplitude (an index of ability to detect sound image shifts from the centre) and midpoint (an index of deviation of the interaural time diVerence range perceived as the centre) parameters of interaural time diVerence were analysed in each subject using 10 consecutive stable saw toothed waves. Results-The amplitude of interaural time diVerence was significantly higher in patients with right brain damage than in controls. The midpoint of the interaural time diVerence was significantly more deviated in patients with right brain damage than in those with left brain damage and controls (p<0.05). Patients with right brain damage with lesions aVecting both the parietal lobe and auditory pathway showed a significantly higher amplitude and deviated midpoint than the controls, whereas right brain damage with involvement of only the parietal lobe showed a midpoint significantly deviated from the controls (p<0.05). Abnormal sound lateralisation correlated with unilateral visuospatial neglect (p<0.05). Conclusions-The right parietal lobe plays an important part in sound lateralisation. Sound lateralisation is also influenced by lesions of the right auditory pathway, although the eVect of such lesions is less than that of the right parietal lobe. Disturbances of sound lateralisation correlate with unilateral visuospatial neglect. (J Neurol Neurosurg Psychiatry 1999;67:481-486)

What and Where in human audition: selective deficits following focal hemispheric lesions

“…Several studies reported mis-localization within the hemispace contralateral to the brain lesion, after right or left hemispheric lesions (Wortis and Pfeffer 1948;Sanchez-Longo and Forster 1958;Klingon and Bontecou 1966;Poirier et al 1994;Zatorre et al 1995). Other studies described deficits within the whole field following unilateral lesions (Haeske-Dewick et al 1996;Zatorre and Penhune 2001) and some advocated either right (Ruff et al 1981;Bisiach et al 1984;Tanaka et al 1999) or left (Pinek et al 1989) hemispheric specialization for auditory localization. While some authors attributed impaired sound localization exclusively to lesions in temporal lobe (Sanchez-Longo and Forster 1958;Efron et al 1983;Zatorre and Penhune 2001), others questioned its importance in sound localization (Jerger et al 1972) or reported auditory spatial deficits following parietal lobe lesions (Bisiach et al 1984;Pinek and Brouchon 1992;Griffiths et al 1997).…”

Unilateral hemispheric lesions disrupt parallel processing within the contralateral intact hemisphere: an auditory fMRI study

“…Several studies reported mislocalization within the hemispace contralateral to the brain lesion, after right or left hemispheric lesions (Wortis and Pfeffer, 1948;Sanchez-Longo and Forster, 1958;Klingon and Bontecou, 1966;Poirier et al, 1994;Zatorre et al, 1995). Other studies described deficits within the whole field following unilateral lesions (Haeske-Dewick et al, 1996;Zatorre and Penhune, 2001) and some advocated either right (Ruff et al, 1981;Bisiach et al, 1984;Tanaka et al, 1999) or left (Pinek et al, 1989) hemispheric specialization for auditory localization.…”

Avaliação comportamental, eletroacústica e eletrofisiológica da audição em pacientes com lesão isquêmica do hemisfério direito

“…Ainda, na mesma literatura especializada, a média de idade encontrada para os pacientes com lesão foi: 61 e 63 anos (De Renzi et al, 1989), 36 anos (Obert e Cranford, 1990), 64 anos (Robertson et al, 1997), 56 anos Discussão (Tanaka et al, 1999), 58 anos (Deouell et al, 2000), 63 anos (Bamiou et al, 2006), 40, 53 e 55 anos (Biedermann et al, 2008), 67 e 73 anos (Gopinath et al, 2009). Pudemos verificar que a maioria destes estudos mostrou média de idade acima de 40 anos, desta forma, a presente pesquisa apresentou média de idade semelhante àquela encontrada pela literatura especializada.…”

“…(Bisiach et al, 1984, Kileny et al, 1987, Obert e Cranford, 1990, Tanaka et al, 1999, Deouell et al, 2000, Bellmann et al, 2001, Adriani et al, 2003, Alvarenga et al, 2005, Bamiou et al, 2006, Biedermann et al, 2008, Gopinath et al, 2009). …”

“…Alvarenga et al (2005) Kileny et al (1987) (Bisiach et al, Discussão 1984, Tanaka et al,1999, Bellmann et al,2001, Adriani et al,2003, de resolução temporal (De Renzi et al,1989, Bamiou et al, 2006, de atenção auditiva sustentada (Robertson et al,1997), de padrão de freqüência, intensidade e duração (Biedermann et al,2008) A tabela 19 e o gráfico 2 mostraram as comparações dos valores de latências das ondas P300, entre as orelhas direita e esquerda, para ambos os grupos. Verificamos que não houve diferença estatisticamente significante entre as orelhas para o grupo controle, porém, encontramos uma tendência à diferença estatística entre as orelhas para o grupo pesquisa.…”