What and Where in human audition: selective deficits following focal hemispheric lesions

Clarke, Stéphanie; Thiran, Anne Bellmann; Maeder, Philippe; Adriani, Michela; Vernet, Olivier; Regli, Luca; Cuisenaire, O.; Thiran, Jean‐Philippe

doi:10.1007/s00221-002-1203-9

Cited by 195 publications

(87 citation statements)

References 65 publications

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“…Auditory processing is thought to be mediated by partially segregated "what" and "where" pathways involved in sound recognition and localization, respectively (Rauschecker, 1998;Hackett et al, 1999;Clarke et al, 2000Clarke et al, , 2002Tian et al, 2001;Clarke and Thiran, 2004;De Santis et al, 2007). Previous studies have demonstrated plastic changes within the "what" stream as subjects learned to discriminate between frequency, duration, or intensity of sounds or between semantic features of complex environmental sounds or speech (Tremblay et al, 1998;Jäncke et al, 2001;Syka, 2002;Bergerbest et al, 2004;Gottselig et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Learning-Induced Plasticity in Auditory Spatial Representations Revealed by Electrical Neuroimaging

Spierer¹,

Tardif²,

Sperdin³

et al. 2007

J. Neurosci.

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Auditory spatial representations are likely encoded at a population level within human auditory cortices. We investigated learninginduced plasticity of spatial discrimination in healthy subjects using auditory-evoked potentials (AEPs) and electrical neuroimaging analyses. Stimuli were 100 ms white-noise bursts lateralized with varying interaural time differences. In three experiments, plasticity was induced with 40 min of discrimination training. During training, accuracy significantly improved from near-chance levels to ϳ75%. Before and after training, AEPs were recorded to stimuli presented passively with a more medial sound lateralization outnumbering a more lateral one (7:1). In experiment 1, the same lateralizations were used for training and AEP sessions. Significant AEP modulations to the different lateralizations were evident only after training, indicative of a learning-induced mismatch negativity (MMN). More precisely, this MMN at 195-250 ms after stimulus onset followed from differences in the AEP topography to each stimulus position, indicative of changes in the underlying brain network. In experiment 2, mirror-symmetric locations were used for training and AEP sessions; no training-related AEP modulations or MMN were observed. In experiment 3, the discrimination of trained plus equidistant untrained separations was tested psychophysically before and 0, 6, 24, and 48 h after training. Learning-induced plasticity lasted Ͻ6 h, did not generalize to untrained lateralizations, and was not the simple result of strengthening the representation of the trained lateralizations. Thus, learning-induced plasticity of auditory spatial discrimination relies on spatial comparisons, rather than a spatial anchor or a general comparator. Furthermore, cortical auditory representations of space are dynamic and subject to rapid reorganization.

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Section: Discussionmentioning

confidence: 99%

Learning-Induced Plasticity in Auditory Spatial Representations Revealed by Electrical Neuroimaging

Spierer¹,

Tardif²,

Sperdin³

et al. 2007

J. Neurosci.

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show abstract

“…Regions responding to the crossmodal recognition task more than the localization task were found in the bilateral inferior occipital gyrus and the left lateral temporal cortex including the anterior part of STS and STG. However, severely deficient in auditory motion perception and partially deficient in auditory localization, but normal in recognition of environmental sounds, was accompanied with damage to a dorsal temporo-parieto-frontal region [52,53] .…”

Section: Cross-modal Studiesmentioning

confidence: 99%

The dual-pathway model of auditory signal processing

Wang

2008

Neurosci. Bull.

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Similar to the visual dual-pathway model, neurophysiological studies in non-human primates have suggested that the dual-pathway model is also applicable for explaining auditory cortical processing, including the ventral "what" pathway for object identification and the dorsal "where" pathway for spatial localization. This review summarizes evidence from human neuroimaging studies supporting the dual-pathway model for auditory cortical processing in humans.

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“…Evidence from both monkeys and humans had already suggested that there were multisynaptic corticocortical pathways in audition paralleling those in vision (Bruce et al, 1981;Wang et al, 1995;Andersen, 1997;Romanski et al, 1999;Rauschecker and Tian, 2000;Clarke et al, 2002;Kaiser et al, 2003;Rama et al, 2004;For review see, Shroeder and Fox, 2005). The metabolic mapping study not only lends strong support to that notion, but also allows simultaneous visualization of the territory occupied by all three of these proposed pathways.…”

Section: Comparison Of Auditory and Visual Mapsmentioning

confidence: 99%

Exploring the extent and function of higher-order auditory cortex in rhesus monkeys

Poremba

Mishkin

2007

Hearing Research

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Just as cortical visual processing continues far beyond the boundaries of early visual areas, so too does cortical auditory processing continue far beyond the limits of early auditory areas. In passively listening rhesus monkeys examined with metabolic mapping techniques, cortical areas reactive to auditory stimulation were found to include the entire length of the superior temporal gyrus (STG) as well as several other regions within the temporal, parietal, and frontal lobes. Comparison of these widespread activations with those from an analogous study in vision supports the notion that audition, like vision, is served by several cortical processing streams, each specialized for analyzing a different aspect of sensory input, such as stimulus quality, location, or motion. Exploration with different classes of acoustic stimuli demonstrated that most portions of STG show greater activation on the right than on the left regardless of stimulus class. However, there is a striking shift to left hemisphere "dominance" during passive listening to species-specific vocalizations, though this reverse asymmetry is observed only in the region of temporal pole. The mechanism for this left temporal pole "dominance" appears to be suppression of the right temporal pole by the left hemisphere, as demonstrated by a comparison of the results in normal monkeys with those in split-brain monkeys.

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What and Where in human audition: selective deficits following focal hemispheric lesions

Cited by 195 publications

References 65 publications

Learning-Induced Plasticity in Auditory Spatial Representations Revealed by Electrical Neuroimaging

Learning-Induced Plasticity in Auditory Spatial Representations Revealed by Electrical Neuroimaging

The dual-pathway model of auditory signal processing

Exploring the extent and function of higher-order auditory cortex in rhesus monkeys

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