Sortilin restricts secretion of apolipoprotein B-100 by hepatocytes under stressed but not basal conditions

Sorting through the extensive and confusing roles of sortilin in metabolic disease

“…However, under conditions where the cell has excess proBDNF, sortilin targets this excess to the endolysosomal system for degradation ( 10 , 84 ). In hepatocytes, sortilin may traffic apoB-100 toward the secretory pathway for secretion or toward the lysosome for degradation, depending on the metabolic context ( 114 , 115 , 170 ). The mechanism underlying these switches is unknown.…”

“…( 9 ) McA cells NA NA Plasmid NA — ND Conlon et al. ( 170 ) hAPOB McA cells NA NA Plasmid NA ↓ ND Amengual et al. ( 116 ) hAPOB McA cells NA NA Plasmid NA ↓ ND Conlon et al.…”

“…( 116 ) hAPOB McA cells NA NA Plasmid NA ↓ ND Conlon et al. ( 170 ) HepG2 cells NA NA AV NA ↓ ND Bi et al. ( 39 ) WT mouse heps CD ♂ AV NA ↓ ND Bi et al.…”

“…( 9 ) WT mice CD ♂ AAV8-TBG ↓ — ND Conlon et al. ( 170 ) WT mice CD ♂ AV ↓ ND ND Bi et al. ( 39 ) WT mice CD NR AAV8 ND — ND Ai et al.…”

“…( 20 ) WT mice HFD ♂ AAV8-TBG ↓ ↓ ND Conlon et al. ( 170 ) WT mice HFD NR AAV8 ND ↓ ND Ai et al. ( 40 ) Apo bec −/− ; APOB Tg mice CD NR AAV8-TBG ↓ ↓ ND Musunuru et al.…”