Sortilin-Driven Cancer Secretome Enhances Tumorigenic Properties of Hepatocellular Carcinoma via de Novo Lipogenesis

Chan, Kristy Kwan-Shuen; Au, Kwan-Yung; Suen, Long-Hin; Leung, Bernice; Wong, Cheuk-Yan; Leow, Wei-Qiang; Lim, Tony Kiat-Hon; Ng, Irene Oi-Lin; Chung, Clive Yik-Sham; Lo, Regina Cheuk-Lam

doi:10.1016/j.ajpath.2023.08.005

Cited by 1 publication

(2 citation statements)

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“…Failure to accurately sort and recycle receptors has been linked to a number of human diseases including cancer ( Carosi et al, 2023 ). Some retromer-associated proteins, such as sorting nexin-27 (SNX27) and sortilin, are overexpressed and correlate with cancer progression and metastasis in prostate, liver, colorectal and breast cancer ( Table 1 ) ( Berger et al, 2021 ; Blondy et al, 2021 ; Chan et al, 2023 ; Gao et al, 2022 ; Martini et al, 2022 ; Sharma et al, 2019 ; Ye et al, 2022 ).…”

Section: Adaptations In Endocytosis Support Tumour Growth and Metabol...mentioning

confidence: 99%

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Adaptations of membrane trafficking in cancer and tumorigenesis

Evergren,

Mills,

Kennedy

2024

Journal of Cell Science

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Membrane trafficking, a fundamental cellular process encompassing the transport of molecules to specific organelles, endocytosis at the plasma membrane and protein secretion, is crucial for cellular homeostasis and signalling. Cancer cells adapt membrane trafficking to enhance their survival and metabolism, and understanding these adaptations is vital for improving patient responses to therapy and identifying therapeutic targets. In this Review, we provide a concise overview of major membrane trafficking pathways and detail adaptations in these pathways, including COPII-dependent endoplasmic reticulum (ER)-to-Golgi vesicle trafficking, COPI-dependent retrograde Golgi-to-ER trafficking and endocytosis, that have been found in cancer. We explore how these adaptations confer growth advantages or resistance to cell death and conclude by discussing the potential for utilising this knowledge in developing new treatment strategies and overcoming drug resistance for cancer patients.

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Section: Adaptations In Endocytosis Support Tumour Growth and Metabol...mentioning

confidence: 99%

“…Autophagy intersects with multiple membrane trafficking pathways, including the COPII, COPI and endocytic pathways. 1) (Berger et al, 2021;Blondy et al, 2021;Chan et al, 2023;Gao et al, 2022;Martini et al, 2022;Sharma et al, 2019;Ye et al, 2022).…”

Section: The Retromer Complex Regulates Glucose Transporters In Cance...mentioning

confidence: 99%