Sorption of Rare-Earth Elements and Ac on UTEVA Resin in Different Acid Solutions

Marinov, G.; Marinova, A.; Milanova, Maria; Happel, Steffen; Lebedev, N.A.; Drokhlyansky, Abigail; Mirzayev, N.A.; Karaivanov, Dimitar Petkov; Filosofov, D.V.

doi:10.1080/07366299.2017.1336404

Cited by 9 publications

(2 citation statements)

References 15 publications

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“…Separation of 225 Ac from 225 Ra is then achieved with cation-exchange chromatography, which is loaded in 0.1 M HNO 3 , 225 Ra eluted with 1.2 M HNO 3 , and finally 225 Ac eluted with 8 M HNO 3 . Recently, there have been a number of studies attempting to develop simple and robust purification systems for 225 Ac, many of which employ either UTEVA or DGA, among other resins. − …”

Section: Actiniummentioning

confidence: 99%

Radioactive Main Group and Rare Earth Metals for Imaging and Therapy

2018

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Radiometals possess an exceptional breadth of decay properties and have been applied to medicine with great success for several decades. The majority of current clinical use involves diagnostic procedures, which use either positron-emission tomography (PET) or single-photon imaging to detect anatomic abnormalities that are difficult to visualize using conventional imaging techniques (e.g., MRI and X-ray). The potential of therapeutic radiometals has more recently been realized and relies on ionizing radiation to induce irreversible DNA damage, resulting in cell death. In both cases, radiopharmaceutical development has been largely geared toward the field of oncology; thus, selective tumor targeting is often essential for efficacious drug use. To this end, the rational design of fourcomponent radiopharmaceuticals has become popularized. This Review introduces fundamental concepts of drug design and applications, with particular emphasis on bifunctional chelators (BFCs), which ensure secure consolidation of the radiometal and targeting vector and are integral for optimal drug performance. Also presented are detailed accounts of production, chelation chemistry, and biological use of selected main group and rare earth radiometals.

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Section: Actiniummentioning

confidence: 99%

Radioactive Main Group and Rare Earth Metals for Imaging and Therapy

2018

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“…Liquid chromatography for the separation of elements is currently used in radiochemistry for elemental and isotopic analyses protocols. The protocols on extraction chromatographic resins are widely implemented on radioactive samples for purified actinides or others elements like lanthanides [78][79][80][81][82][83]. Common methods for actinide matrix removal use chromatographic resin beds that are several milliliters in volume.…”

Section: Solid Phase Extraction (Spe)mentioning

confidence: 99%