Separation of 89Zr from irradiated yttrium targets by extraction chromatography

Production of zirconium-88 via proton irradiation of metallic yttrium and preparation of target for neutron transmission measurements at DICER

“…Another commonly used procedure was developed by Holland and co-workers 19 and includes dissolution of the Y metal target in 6 mol·L −1 HCl at room temperature and addition of H 2 O 2 42 , 46 . Finally, concentrated HCl (10 mol·L −1 or more) is also sometimes used to dissolve Y metal or Y 2 O 3 targets 50 , 51 , in this case 88 Zr or 89 Zr is separated from stable Y using an anion exchange resin. In this work, preliminary experiments with the stable Y metal showed that the optimal HCl concentration for massive (≈20 g) Y target dissolution is 6 mol·L −1 or higher.…”

“…Hydroxamate-based resin can be easily synthesized by functionalizing a weak cation exchange resin with hydroxamate groups using the previously described procedure 19 and is commercially available. Other extraction chromatographic resins (TEVA, UTEVA, TRU and LN resins) can also be used to separate 89 Zr from irradiated Y targets 51 .…”

“…Similar to 88 Zr, high amounts of 89 Zr can be produced via irradiation of either Y metal or Y 2 O 3 in a proton beam but at lower proton energies. Usually, only small targets (1 g or less) have been used www.nature.com/scientificreports/ to produce GBq (mCi) amounts of 88 Zr or 89 Zr and some authors selected yttrium metal 9,19,[42][43][44][45][46][47][48][49] (typically sputtered on Nb or Cu) or pressed yttrium oxide [50][51][52] as a target material. Liquid yttrium nitrate targets have also been studied 42 for the production of 89 Zr.…”

“…Vol:. ( 1234567890 50,51 , in this case 88 Zr or 89 Zr is separated from stable Y using an anion exchange resin. In this work, preliminary experiments with the stable Y metal showed that the optimal HCl concentration for massive (≈20 g) Y target dissolution is 6 mol•L −1 or higher.…”