Sophora alopecuroides var. alopecuroides: Phytochemical composition, antioxidant and enzyme inhibitory activity of the methanolic extract of aerial parts, flowers, leaves, roots, and stems

Arumugam, Radjassegarin; Sarıkürkçü, Cengiz; Mutlu, Muzaffer; Tepe, Bektaş

doi:10.1016/j.sajb.2020.10.009

Cited by 11 publications

(8 citation statements)

References 38 publications

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“…According to Ghimire et al (2011), the existence of bioactive chemicals such as phenolics, flavonoids, and tannins in different plant sections could reflect the varying scavenging activities. The perusal of available literature indicates a clear link between the radical scavenging ability of plant extracts and phytochemical contents (Arumugam et al, 2019(Arumugam et al, , 2020Namvar et al, 2017). The current findings also support the view of Yingming et al (2004), who found that extracts with a high phenolic content were more effective in scavenging free radicals.…”

Section: Dpph Radical Scavenging Ac Vitysupporting

confidence: 87%

Comparative antioxidant, antibacterial and phytochemical analysis of roots, stems, leaves and seeds from Cleome rutidosperma DC

Arumugam¹,

Balachandravinayagam²,

Jayakumar³

et al. 2022

NRFHH

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The emerging microbial infections and their resistance to the existing antibiotics lead to discovering novel compounds, primarily from medicinal plants with secondary metabolites having several bioactive potentials, including antioxidants. The current investigation aims to measure the antioxidant and antibacterial efficacy of ethanolic extracts from roots, stems, leaves and seeds of Cleome rutidosperma. The extracts were subjected to quantitative (total phenolic and flavonoid), qualitative phytochemical studies, and functional groups identification by FT-IR analysis. The extract of leaves showed the highest total antioxidant (54.21±1.56 mg ABAE/g), DPPH (62.92±1.94 mg GAEs/g), and FRAP (71.64±2.02 mg GAEs/g) activity among the all-tested parts. The antibacterial efficacy of extracts was determined by the microdilution bioassay method, which demonstrated that G(+ve) bacteria appear to be more susceptible to the crude extracts than G (-ve) bacteria. The qualitative phytochemical screening-detected alkaloids, flavonoids, phenols, sugars, proteins, saponins, sterols, tannins, and terpenoids. The leaves have the highest levels of phenolics (70.451.23 mg GAE/g DW) and flavonoids (32.261.12 mg RE/g DW) among the all-tested parts. The extracts' functional group was validated using the FT-IR spectra. Polyphenols, flavonoids, and tannins were identified in the crude extracts. These findings imply that C. rutidoserma could be a promising candidate for further research into infectious illness treatment and as a resource of novel antioxidants in nutraceutical and biopharmaceutical industries as a functional additive.

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Section: Dpph Radical Scavenging Ac Vitysupporting

confidence: 87%

Comparative antioxidant, antibacterial and phytochemical analysis of roots, stems, leaves and seeds from Cleome rutidosperma DC

Arumugam¹,

Balachandravinayagam²,

Jayakumar³

et al. 2022

NRFHH

Self Cite

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“…For example, recent papers have shown that the Folin–Ciocalteu assay measures reducing power instead of total phenolics content [ 54 ]. To obtain more accurate levels of total phenolics, at least one chromatographic technique has been suggested recently [ 55 , 56 , 57 ]. In this sense, the chemical profile of K. parviflora extracts was identified by LC-MS/MS.…”

Section: Resultsmentioning

confidence: 99%

Establishment of a Rapid Micropropagation System for Kaempferia parviflora Wall. Ex Baker: Phytochemical Analysis of Leaf Extracts and Evaluation of Biological Activities

Park

Kim

et al. 2021

Plants

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This study aimed to establish a rapid in vitro plant regeneration method from rhizome buds of Kaempferia parviflora to obtain the valuable secondary metabolites with antioxidant and enzyme inhibition properties. The disinfection effect of silver oxide nanoparticles (AgO NPs) on rhizome and effects of plant growth regulators on shoot multiplication and subsequent rooting were investigated. Surface sterilization of rhizome buds with sodium hypochlorite was insufficient to control contamination. However, immersing rhizome buds in 100 mg L−1 AgO NPs for 60 min eliminated contamination without affecting the survival of explants. The number of shoots (12.2) produced per rhizome bud was higher in Murashige and Skoog (MS) medium containing 8 µM of 6-Benzyladenine (6-BA) and 0.5 µM of Thidiazuron (TDZ) than other treatments. The highest number of roots (24), with a mean root length of 7.8 cm and the maximum shoot length (9.8 cm), were obtained on medium MS with 2 µM of Indole-3-butyric acid (IBA). A survival rate of 98% was attained when plantlets of K. parviflora were acclimatized in a growth room. Liquid chromatography with tandem mass spectrometry (LC-MS/MS) was used to determine the chemical profile of K. parviflora leaf extracts. Results showed that several biologically active flavonoids reported in rhizomes were also present in leaf tissues of both in vitro cultured and ex vitro (greenhouse-grown) plantlets of K. parviflora. We found 40 and 36 compounds in in vitro cultured and ex vitro grown leaf samples, respectively. Greenhouse leaves exhibited more potent antioxidant activities than leaves from in vitro cultures. A higher acetylcholinesterase inhibitory ability was obtained for greenhouse leaves (1.07 mg/mL). However, leaves from in vitro cultures exhibited stronger butyrylcholinesterase inhibitory abilities. These results suggest that leaves of K. parviflora, as major byproducts of black ginger cultivation, could be used as valuable alternative sources for extracting bioactive compounds.

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“…The UV spectrum showed absorption bands ( λ max 202 and 260 nm) characteristic for α , β ‐unsaturated lactam chromophore. The 1 H NMR spectrum of 1 showed the existence of two coupled olefinic protons of [ δ H 6.57 dd ( J = 9.0, 6.3 Hz), 5.91 d ( J = 9.0 Hz)], and two sets characteristic protons for C‐17 in matrine‐type scaffold at [ δ H 4.23 dd ( J = 12.5, 4.3 Hz), 3.14 t ( J = 12.5 Hz); and 4.07 overlapped, 3.17 t ( J = 12.5 Hz)]. The 13 C and DEPT NMR spectroscopic data revealed the presence of total 30 carbon resonances, comprising two amide carbons ( δ C 171.1 and 165.8), a double bond ( δ C 142.3 and 124.9), ten sp 3 methines, and sixteen sp 3 methylenes (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…Sophora alopecuroides L., is a perennial herb plant found in arid desert grassland of northwest China and some Asian countries. [ 1 ] The seeds of S. alopecuroides (known as “Ku‐Dou‐Zi” in China) were used as traditional Chinese medicine for the treatment of many kinds of illnesses such as fever, rheumatism, bacterial infection and inflammatory diseases. [ 2‐3 ] Previous phytochemical and pharmacological investigations of the S. alopecuroides extracts revealed that matrine‐type alkaloids are one of principal active chemical constituents, [ 4‐7 ] which are responsible for diverse intriguing bioactivities such as antiviral, [ 8 ] anti‐tumor, [ 9‐10 ] and promising anti‐inflammatory activities.…”

Section: Background and Originality Contentmentioning

confidence: 99%

Structurally Diverse Matrine‐Based Alkaloids with Anti‐inflammatory Effects from Sophora alopecuroides

et al. 2021

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Main observation and conclusion A phytochemical investigation on the seeds of Sophora alopecuroides led to obtaining fourteen structurally diverse matrine‐based alkaloids (1—14), including eight new ones (1, 6, 8—12, 14). Notably, alopecuroide F (1) represents the first dimeric matrine‐type skeleton assembled via unprecedent C‐13–C‐12' connection. The new structures were determined through extensive spectroscopic data (UV, OR, HRESIMS, 1D, and 2D NMR), ECD calculations, and three instances, verified by X‐ray crystallography. Biologically, all alkaloids were evaluated for cytotoxicity against four human cancer cell lines (HepG2, A549, THP‐1, and MCF‐7) and anti‐inflammatory activities for two pro‐inflammatory cytokines (TNF‐α and IL‐6). Alopecuroide F (1) can inhibit TNF‐α and IL‐6 productions in a dose‐dependent manner, with IC50 values of 35.6 ± 0.5 and 41.7 ± 0.8 μmol/L, respectively.

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Sophora alopecuroides var. alopecuroides: Phytochemical composition, antioxidant and enzyme inhibitory activity of the methanolic extract of aerial parts, flowers, leaves, roots, and stems

Cited by 11 publications

References 38 publications

Comparative antioxidant, antibacterial and phytochemical analysis of roots, stems, leaves and seeds from <i>Cleome rutidosperma</i> DC

Comparative antioxidant, antibacterial and phytochemical analysis of roots, stems, leaves and seeds from <i>Cleome rutidosperma</i> DC

Establishment of a Rapid Micropropagation System for Kaempferia parviflora Wall. Ex Baker: Phytochemical Analysis of Leaf Extracts and Evaluation of Biological Activities

Structurally Diverse Matrine‐Based Alkaloids with Anti‐inflammatory Effects from Sophora alopecuroides

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