Sophalines E–I, Five Quinolizidine-Based Alkaloids with Antiviral Activities against the Hepatitis B Virus from the Seeds of <i>Sophora alopecuroides</i>

Zhang, Yubo; Yang, Li; Luo, Dan; Chen, Neng‐Hua; Wu, Zhong‐Nan; Ye, Wen‐Cai; Wang, Guo‐Cai

doi:10.1021/acs.orglett.8b02637

Cited by 43 publications

(32 citation statements)

References 19 publications

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“…Quinolizidine alkaloids are a group of alkaloids possessing a quinolizidine ring or a piperidine ring with diversified pharmacological properties, including cytotoxic, oxytocic, antipyretic, antibacterial, antiviral, and hypoglycemic activities (Bunsupa et al, 2012). Sophocarpine ( 1 ) and sophoridine ( 2 ) are two active quinolizidine alkaloids isolated from Sophora alopecuroides , which distributes in western and central Asia and been used as traditional Chinese medicine for the treatment of bacterial infections, fever, rheumatism, and cardiovascular diseases (Zhang Y.-B. et al, 2018).…”

Section: Plant-based Alkaloids Against Ibdmentioning

confidence: 99%

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease

Jiao

Zheng

et al. 2019

Front. Pharmacol.

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Inflammatory bowel disease (IBD) represents a group of intestinal disorders with self-destructive and chronic inflammation in the digestive tract, requiring long-term medications. However, as many side effects and drug resistance are frequently encountered, safer and more effective agents for IBD treatment are urgently needed. Over the past few decades, a variety of natural alkaloids made of plants or medicinal herbs have attracted considerable interest because of the excellent antioxidant and anti-inflammatory properties; additionally, these alkaloids have been reported to reduce the colonic inflammation and damage in a range of colitic models. In this review paper, we summarize the recent findings regarding the anti-colitis activity of plant-derived alkaloids and emphasize their therapeutic potential for the treatment of IBD; obvious improvement of the colonic oxidative and pro-inflammatory status, significant preservation of the epithelial barrier function and positive modulation of the gut microbiota are the underlying mechanisms for the plant-derived alkaloids to treat IBD. Further clinical trials and preclinical studies to unravel the molecular mechanism are essential to promote the clinical translation of plant-derived alkaloids for IBD.

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Section: Plant-based Alkaloids Against Ibdmentioning

confidence: 99%

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease

Jiao

Zheng

et al. 2019

Front. Pharmacol.

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“…Besides, P2X 7 receptors may be related to the comorbidity of DNP and depression [62]. Palmatine treatment ameliorated the comorbidity of DNP and depression via reducing the expression of TNF-α, IL-1β mRNA, and phosphorylation of extracellular regulates protein kinases 1/2(ERK1/2) protein in the hippocampus of [156] Kudouzi Sophora alopecuroides [156][157][158] Kushen Sophora flavescens [156,159] Shandougen Sophora subprostrata [156] Oxymatrine 16837-52-8 C 15 H 24 N 2 O 2 Baicihua Sophora davidii [156] Kudouzi Sophora alopecuroides [157,158] Kushen Sophora flavescens [159] Shashenhuai Sophora moorcroftiana [156] Shandougen Sophora subprostrata [156] Isoquinoline DPN rats [43]. ATP-induced activation of P2X 3 receptors might collaborate with the phosphorylation of P38 mitogen-activated protein kinase (P38MAPK) in DRG, causing mechanical and heat hyperalgesia [63].…”

Section: Regulation Of Alkaloids On Oxidative Stress and Neuroinflammmentioning

confidence: 99%

Effects of alkaloids on peripheral neuropathic pain: a review

et al. 2020

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Neuropathic pain is a debilitating pathological pain condition with a great therapeutic challenge in clinical practice. Currently used analgesics produce deleterious side effects. Therefore, it is necessary to investigate alternative medicines for neuropathic pain. Chinese herbal medicines have been widely used in treating intractable pain. Compelling evidence revealed that the bioactive alkaloids of Chinese herbal medicines stand out in developing novel drugs for neuropathic pain due to multiple targets and satisfactory efficacy. In this review, we summarize the recent progress in the research of analgesic effects of 20 alkaloids components for peripheral neuropathic pain and highlight the potential underlying molecular mechanisms. We also point out the opportunities and challenges of the current studies and shed light on further in-depth pharmacological and toxicological studies of these bioactive alkaloids. In conclusion, the alkaloids hold broad prospects and have the potentials to be novel drugs for treating neuropathic pain. This review provides a theoretical basis for further applying some alkaloids in clinical trials and developing new drugs of neuropathic pain.

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“…53 Sophocarpine and sophoridine, isolated from Sophora alopecuroides, have been used as traditional Chinese medicine for treating rheumatism. 54,55 Studies on DSS-induced murine colitis showed that sophocarpine (15, 30, or 60 mg/kg body weight) decreased levels of IL-1b, IL-6, and colonic MPO activity, and improved the symptom of DSSinduced colitis. 56 Berberine, a well-known representative isoquinoline alkaloid that is isolated from Coptis chinensis and Phellodendron chinense, reportedly can protect against colitis by controlling the gut microbiota, the innate and adaptive immune responses, and the function of the intestinal barrier.…”

Section: Phytochemicalsmentioning

confidence: 99%

Nutritional Interventions Using Functional Foods and Nutraceuticals to Improve Inflammatory Bowel Disease

Shin

Lim

2020

Journal of Medicinal Food

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The gastrointestinal tract, the second largest organ in the body, plays an important role in nutrient and mineral intake through the intestinal barrier. Dysfunction of intestinal permeability and related disorders commonly occur in patients with inflammatory bowel disease (IBD), one of the health problems in the Western societies that are considered to be mainly due to the Western diet. Although the exact etiology of IBD has not been elucidated, environmental and genetic factors may be involved in its pathogenesis. Many synthetic or biological drugs, such as 5-aminosalicylic acid corticosteroids as antiinflammatory drugs, have been used clinically to treat IBD. However, their long-term use exhibits some adverse health consequences. Therefore, many researchers have devised alternative therapies to overcome this problem. Many studies have revealed that some functional nutrients in nature can relieve gastrointestinal inflammation by controlling proinflammatory cytokines. In this study, we review the ability of functional nutraceuticals such as phytochemicals, fatty acids, and bioactive peptides in improving IBD by regulating its underlying pathogenic mechanisms.

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Sophalines E–I, Five Quinolizidine-Based Alkaloids with Antiviral Activities against the Hepatitis B Virus from the Seeds of Sophora alopecuroides

Cited by 43 publications

References 19 publications

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease

Effects of alkaloids on peripheral neuropathic pain: a review

Nutritional Interventions Using Functional Foods and Nutraceuticals to Improve Inflammatory Bowel Disease

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