Sonography and neuropathology of a congenital brain tumor: report of a rare incident

Leins, A.; Kainer, F.; Weis, Serge

doi:10.1046/j.1469-0705.2001.00350.x

Cited by 17 publications

(6 citation statements)

References 16 publications

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“…As a group, astrocytomas differ in their gross and histological features as well as in their site of origin and clinical manifestations. 14,[29][30][31][32][33][34][35] Most fetal astrocytomas occurred outside the posterior cranial fossa and above the tentorium (Table 4). When it could be determined, the cerebral hemisphere was the main primary site.…”

Section: Astrocytomamentioning

confidence: 99%

Fetal Brain Tumors: A Review of 154 Cases

Isaacs

2009

Amer J Perinatol

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The purpose of this literature review is to describe the various types of brain tumors that occur in the fetus, their locations, initial findings, pathology, and outcome. Data are presented that show which patients are likely to survive or benefit from treatment compared with those who are unlikely to respond. An analysis is performed on patients with fetal brain tumors that were detected prenatally by imaging studies or discovered directly after birth. The review revealed 154 fetuses presenting with brain tumors. Teratoma was the leading neoplasm. Next was astrocytoma followed by craniopharyngioma, primitive neuroectodermal tumor, choroid plexus papilloma, meningeal tumors, and ependymoma. The most common presenting findings were macrocephaly and an intracranial mass. Overall hydrocephalus was next, followed by stillbirth. Most tumors were detected during the third trimester of pregnancy. Over a third of the affected fetuses were stillborn. Many tumors were inoperable as they occupied much of the intracranial cavity and involved large areas of the brain. Overall survival rate was 23/154, or 15%. Generally fetal brain tumors are associated with a poor prognosis.

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Section: Astrocytomamentioning

confidence: 99%

Fetal Brain Tumors: A Review of 154 Cases

Isaacs

2009

Amer J Perinatol

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“…Arises from the cerebral hemispheres and basal nuclei of fetuses, stillbirths, and infants [21, 23, 24, 30, 38, 43, 49, 68, 72]. It is the leading form of astrocytoma in this and in other similar perinatal studies [12, 15, 30, 31, 68].…”

Section: Resultsmentioning

confidence: 88%

Perinatal (fetal and neonatal) astrocytoma: a review

Isaacs

2016

Childs Nerv Syst

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Introduction The purpose of this review is to document the various types of astrocytoma that occur in the fetus and neonate, their locations, initial findings, pathology, and outcome. Data are presented that show which patients are likely to survive or benefit from treatment compared with those who are unlikely to respond. Materials and methods One hundred one fetal and neonatal tumors were collected from the literature for study. Results Macrocephaly and an intracranial mass were the most common initial findings. Overall, hydrocephalus and intracranial hemorrhage were next. Glioblastoma (GBM) was the most common neoplasm followed in order by subependymal giant cell astrocytoma (SEGA), low-grade astrocytoma, anaplastic astrocytoma, and desmoplastic infantile astrocytoma (DIA). Tumors were detected most often toward the end of the third trimester of pregnancy. Conclusion A number of patients were considered inoperable since their tumor occupied much of the intracranial cavity involving large areas of the brain. High-grade astrocytomas were more common than low-grade ones in this review. Fetuses and neonates with astrocytoma have a mixed prognosis ranging from as low as 20 % (GBM) to a high of 90 %. The overall survival was 47/101 or 46 %.

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“…Many were very poorly differentiated, showing glial differentiation only after immunohistochemical staining for glial fibrillary acidic protein. A report by Leins et al 14 described an undifferentiated tumor, but their illustrations suggested a glioblastoma. In 1 case, staining for p53 protein overexpression, a feature seen in about 50% of adult glioblastomas, was performed, but the results were negative.…”

Section: Discussionmentioning

confidence: 99%

“…3 There have been at least 13 reports of antenatal detection of a glioblastoma in utero. [3][4][5][6][7][8][9][10][11][12][13][14] We present a case in which the initial sonographic impression was that of an arteriovenous malformation with multifocal hemorrhage versus an intracranial neoplasm and in which subsequent prenatal magnetic resonance imaging (MRI) allowed a more definitive diagnosis of an aggressive central nervous system tumor.…”

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confidence: 99%