Congenital glioblastoma multiforme: prenatal diagnosis on the basis of sonography and magnetic resonance imaging.

Morof, Diane; Levine, Deborah; Stringer, Keith; Grable, Ian; Folkerth, Rebecca D.

doi:10.7863/jum.2001.20.12.1369

Cited by 19 publications

(15 citation statements)

References 21 publications

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“…Routine foetal ultrasonography is the main tool for diagnosis antenatally with noted macrocephaly or a hyperechogenic intracranial mass [12]. If a lesion is detected, then foetal MRI can be a useful adjunct for diagnosis, assessment of vascularity and haemorrhage, and detection of other congenital malformations [1,11]. Diagnosis post-partum, as in our case, is usually made by MRI triggered by signs of macrocephaly, a bulging fontanelle, or other symptoms of raised intracranial pressure.…”

Section: Discussionmentioning

confidence: 99%

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Congenital Glioblastoma Multiforme: Complete Resection with Long-Term Survival and a Novel Technique of Contralateral Cystoventriculostomy

et al. 2012

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Congenital glioblastomas are rare primary tumours of the central nervous system with poor prognosis if left untreated. We report the case of a 4-week-old infant with such a tumour treated by surgical excision and a course of postoperative chemotherapy. After the chemotherapy, the patient displayed a neurological deterioration and follow-up magnetic resonance imaging (MRI) scans revealed no signs of recurrence, but showed entrapment and significant distension of the right lateral ventricle. A novel technique of contralateral cystoventriculostomy was performed to attempt to decompress the cyst and improve the infant's neurological status. After surgery there was a significant neurological improvement, and 30 months after resection the child is alive, with mild hemiparesis and no signs of recurrence on follow-up MRI scan. The cystoventriculostomy is patent and continues to decompress the encapsulated ventricle.

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Section: Discussionmentioning

confidence: 99%

“…Congenital supratentorial primary central nervous system tumours are a rare entity [1], of which congenital glioblastomas represent only a very small proportion (3.5%) [2]. They were first described by Holt in 1917 [3], and few cases have been reported in the literature [4,5].…”

Section: Introductionmentioning

confidence: 99%

Congenital Glioblastoma Multiforme: Complete Resection with Long-Term Survival and a Novel Technique of Contralateral Cystoventriculostomy

et al. 2012

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“…Several cases of congenital malignant gliomas, including glioblastomas, have been reported [5,6,7,8,9,10,11,12], and some patients survived in the long term after surgical resection and chemotherapy [6, 9, 12]. Hall et al [24] described a case of anaplastic ganglioglioma in an infant who did well for 20 months after the operation without evidence of tumor recurrence on subsequent CT scans.…”

Section: Discussionmentioning

confidence: 99%

“…Solitare and Krigman [2] specified three categories of congenital brain tumors: (1) definitely congenital – present or producing symptoms at birth; (2) probably congeni tal – present or producing symptoms within the first week; (3) possibly congenital – present or producing symptoms within the first months of life. The period of 2 months, first proposed by Arnstein et al [3], is the more widely accepted limit for defining congenital brain tumors [1, 4], and several cases of congenital malignant gliomas, including glioblastomas, have been reported [5,6,7,8,9,10,11,12]. …”

Section: Introductionmentioning

confidence: 99%

Successful Chemotherapy for Congenital Malignant Gliomas: A Report of Two Cases

et al. 2006

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We describe the cases of 2 patients with a congenital malignant glioma that responded to chemotherapy. In the first case, a 2-month-old boy had a conjugate deviation to the right side and nystagmus. A T₁-weighted gadolinium-enhanced magnetic resonance image showed a large tumor in his right frontal lobe. The tumor was partially resected, and the histological diagnosis was malignant ganglioglioma. The child then underwent 6 cycles of chemotherapy (mainly carboplatin and etoposide), and the residual tumor shrank. The tumor was then partially resected during a second operation, after which the patient underwent 5 cycles of chemotherapy (a combination of carboplatin, etoposide, vincristine, ifosfamide, cisplatin and cyclophosphamide). The tumor has not recurred in more than 8.5 years. In the second case, a 2-month-old boy had bulging of the anterior fontanel. The T₁-weighted gadolinium-enhanced magnetic resonance image showed a large suprasellar tumor. The tumor was partially resected, and the histological diagnosis was anaplastic astrocytoma. The patient underwent 8 cycles of chemotherapy (MCNU, carboplatin and etoposide) and the tumor has not recurred in more than 7.5 years. Our experience indicates that, if surgical removal and chemotherapy are done aggressively for malignant gliomas in neonates and infants, long-term survival is possible.

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“…In cases where follow-up imaging is available, significant change in the size of the intracranial mass might be described, not only due to the tumor's reported tendency to increase rapidly, but sometimes due to the presence of hemorrhage as well (►Table 1). 2,4,9,29,35 It should be noted that there are no specific diagnostic criteria for congenital GBM. Other congenital brain tumors, as well as vascular malformations, infarctions, and primary hemorrhage should be included in the differential diagnosis since a definite diagnosis cannot be made only by prenatal sonography.…”

Section: Antenatal Diagnosismentioning

confidence: 99%

Congenital Glioblastoma Multiforme: An Unusual and Challenging Tumor

et al. 2017

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Congenital glioblastoma multiforme is a rare tumor of the central nervous system with unique features. The existing evidence on its pathogenesis, genetic and molecular profile, special characteristics, treatment, and prognosis is reviewed. An increased number of antenatal diagnoses and prolonged survival for those individuals who can tolerate combined surgical resection and chemotherapy has been noted. The overall prognosis, however, remains poor. A better understanding of this unusual entity is important. Further research is needed to discern tumor's pathogenesis and natural history. This will likely lead to the development and implementation of treatment strategies that may decrease mortality and morbidity in these patients.

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Congenital glioblastoma multiforme: prenatal diagnosis on the basis of sonography and magnetic resonance imaging.

Cited by 19 publications

References 21 publications

Congenital Glioblastoma Multiforme: Complete Resection with Long-Term Survival and a Novel Technique of Contralateral Cystoventriculostomy

Congenital Glioblastoma Multiforme: Complete Resection with Long-Term Survival and a Novel Technique of Contralateral Cystoventriculostomy

Successful Chemotherapy for Congenital Malignant Gliomas: A Report of Two Cases

Congenital Glioblastoma Multiforme: An Unusual and Challenging Tumor

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