Sonographic target sign in neurofibromas.

The accuracy of high-resolution ultrasound for evaluating focal lesions of the hand and wrist

“…1,3,4 Nerve tumors also can be diagnosed confidently with ultrasound when the entering/exiting nerve is identified. 2,14 We misdiagnosed one small digital nerve tumor because the entering/exiting nerve was not seen. Glomus tumors, because of their characteristic location and markedly increased internal vascularity, also are diagnosed readily on ultrasound.…”

“…Nevertheless several recent articles and published reviews have described the sonographic features of a variety of solid and cystic lesions of the hand and wrist. [1][2][3][4][5][6][7][8][9][10][11][12][13][14] To our knowledge only one study has assessed the efficacy, role, and limitations of ultrasound of the hand and wrist for several different types of pathologic lesions. 6 These investigators suggested that ultrasound is indicated for the diagnosis and localization of foreign bodies, diagnosis of tendon rupture and other tendon pathologies, and the diagnosis and assessment of occult ganglions.…”

Imaging Presentation of Malignant Peripheral Nerve Sheath Tumor at Sacral Region

“…The target appearance on sonography (hyperechoic center with a hypoechoic periphery) described by Lin et al [7] was presented in most benign peripheral nerve sheath tumors. The target appearance has been attributed to a central fibrocollagenous region and a peripheral myxomatous region [8].…”

High-resolution ultrasound of peripheral neurogenic tumors

“…Another typical sonographic feature of neurofibromas is the so-called "target sign"; this layered aspect, with a hyperechoic centre and a peripheral hypoechoic rim (Fig. 6b), best seen on transverse scans, is due to the ultrastructure of neurofibromas with a fibrocollageneous center surrounded by a myxomateous periphery [16,34,35]. Large lesions often protrude beyond the surface of the nerve, without a clear capsule [3].…”