“…Diagnosis is done in second trimester as oligohydramnios as the alerting sign 7 . Sirenomelia can be differentiated from caudal regression syndrome with presence of "persistent vitelline artery" 1,8 and the syndrome is not associated with any chromosomal abnormality 6 .…”
Section: Discussionmentioning
confidence: 99%
“…2,3 . This lethal anomaly is associated with a number of genitourinary and anorectal defects [3][4] .This syndrome has strong association with maternal Diabetes mellitus with relative risk 1;200-250 and 22% of foetuses will have diabetic mother 5,6 . Intake of haloperidol antenatally is considered a cause for Sirenomelia.…”
“…Diagnosis is done in second trimester as oligohydramnios as the alerting sign 7 . Sirenomelia can be differentiated from caudal regression syndrome with presence of "persistent vitelline artery" 1,8 and the syndrome is not associated with any chromosomal abnormality 6 .…”
Section: Discussionmentioning
confidence: 99%
“…2,3 . This lethal anomaly is associated with a number of genitourinary and anorectal defects [3][4] .This syndrome has strong association with maternal Diabetes mellitus with relative risk 1;200-250 and 22% of foetuses will have diabetic mother 5,6 . Intake of haloperidol antenatally is considered a cause for Sirenomelia.…”
“…The relative risk for developing this syndrome is 1:200 to 1:250 with maternal diabetes and 22% of foetuses with this anomaly will have diabetic mothers. 7 Other environmental risk factors are smoking, heavy metal exposure and retinoic acid. 8 The characteristic finding of Sirenomelia is partial or complete fusion of the lower legs.…”
“…3 Sirenomelili fetüslerin %22'si diyabetik anne bebeğidir. 4,5 Hastalığın patogenezinde öne çıkan iki teori; vasküler çalma sendromu ve defektif blastogenez hipotezidir.…”
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