Sonographic changes of the pancreas in chronic renal failure

Lerch, Markus M.; Riehl, J; Mann, H.; Nolte, I.; Sieberth, H. G.; Matern, Siegfried

doi:10.1007/bf01889225

Cited by 16 publications

(5 citation statements)

References 12 publications

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“…Cystinuria has been associated with a variety of other disorders, including familial pancreatitis [35]. It is not clear whether this association is caused by co-transmission of one of the recently identified trypsinogen mutations that characterize hereditary pancreatitis, might indicate a de novo formation of pancreatic duct calculi in cystinuria or is based on the known association between chronic renal failure and pancreatic disease [36,37].…”

Section: Cystinuriamentioning

confidence: 99%

Acute and Chronic Pancreatitis in Patients with Inborn Errors of Metabolism

et al. 2001

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Section: Cystinuriamentioning

confidence: 99%

Acute and Chronic Pancreatitis in Patients with Inborn Errors of Metabolism

et al. 2001

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“…Duct calculi in patients with cystinuria, chronic renal insufficiency or renal failure may adversely affect the pancreas [37,38]. Lysinuric protein intolerance leads to inflammatory changes, necrosis, intraductal protein plugs, atrophy, and fibrosis in the pancreas [39,40]. Furthermore, pancreatitis has been reported in patients with pyruvate kinase deficiency [41] and acute intermittent porphyria [42][43][44][45][46].…”

Section: Discussionmentioning

confidence: 99%

Pancreatic involvement in patients with inborn errors of metabolism

Hwang

Lim

Kim

et al. 2021

Orphanet J Rare Dis

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Background Repeated inflammation of the pancreas can cause pancreatitis or diabetes. It is well recognized that the organic acidemias may be complicated by pancreatitis but less recognized are other metabolic disorders in which pancreatitis can occur. This study shows that long-term follow-up of patients with various metabolic disorders in Korea revealed several with episodes of isolated pancreatitis or diabetes concomitantly with pancreatitis. Results and discussion In this study, two patients with methylmalonic aciduria (MMA), two with propionic acidemia (PPA), one with fatty acid oxidation disorder (FAOD), and one with hyperornithinemia, gyrate atrophy, and juvenile onset diabetes mellitus (DM) were clinically followed for up to 10 – 21 years. Two Korean siblings with MMA showed recurrent pancreatitis from the age of 15 and 19, respectively. The frequency of admission due to pancreatitis was up to 11 times. One patient with MMA developed diabetes mellitus at the age of 20. The other patient with MMA developed recurrent pancreatitis at 4 years and diabetes at 8 years of age. One of the patients with PPA presented with diabetic ketoacidosis. The other PPA patient died of cardiac arrest at age 10. The patient with FAOD presented with pancreatitis at 10 years and died at the age of 15 years due to cardiac arrest. A 35-year-old woman with hyperornithinemia/gyrate atrophy was diagnosed with juvenile onset diabetes at the age of 7 years. No pancreatitis occurred during the follow-up period. Conclusions We conclude that various metabolic disorders can trigger acute or chronic pancreatitis. Proper and prompt multidisciplinary management of metabolic derangement is crucial for preventing pancreatic damage. Further clinical and investigational studies are required to elucidate the pathogenesis of pancreatitis and diabetes mellitus in patients with inborn errors in metabolism.

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“…Abdominal ultrasound in four planes (Picker 9000, 3.5 curved linear array) was evaluated as previously described [8]. Dilatation of the pancreatic duct > 4 mm, parenchymal calcifications and circumscript lesions like cysts and nodules were considered evidence of pancreatic disease.…”

Section: Methodsmentioning

confidence: 99%

Diagnostic value of indirect pancreatic function test in serum of anuric patients with chronic renal failure

Lerch¹,

Nolte²,

Riehl³

et al. 1994

Scandinavian Journal of Clinical and Laboratory Investigation

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Although patients with chronic renal failure have a high incidence of chronic pancreatic disease, the condition is frequently overlooked. We have modified the pancreolauryl test--an indirect pancreatic function test--for anuric patients. The test permitted good discrimination between patients with chronic pancreatic disease and those with a normal pancreas when serum levels of fluorescein were measured 10 h after administration with a standard meal. The sensitivity at this time interval was 80% and the specificity 83%. We conclude that the pancreolauryl test with serum measurements provides a simple, noninvasive, and reliable diagnostic test for chronic pancreatic disease in anuric patients with chronic renal failure.

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Sonographic changes of the pancreas in chronic renal failure

Cited by 16 publications

References 12 publications

Acute and Chronic Pancreatitis in Patients with Inborn Errors of Metabolism

Acute and Chronic Pancreatitis in Patients with Inborn Errors of Metabolism

Pancreatic involvement in patients with inborn errors of metabolism

Diagnostic value of indirect pancreatic function test in serum of anuric patients with chronic renal failure

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