Sonodynamic action of hypocrellin B on methicillin-resistant Staphylococcus aureus

Wang, Xinna; Ip, Margaret; Leung, Albert Wingnang; Wang, Pan; Zhang, Hongwei; Hua, Heyu; Xu, Chi

doi:10.1016/j.ultras.2015.10.008

Cited by 28 publications

(29 citation statements)

References 28 publications

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“…[41] Especially, the surface-modified polymeric phenyboronic acid enabled targeted delivery of DOX-loaded titanium dioxide nanoparticles, by which the combined therapeutic effect was realized as demonstrated by the substantially inhibited tumor growth upon US irradiation (15 W cm −2 , 1.5 MHz, duty cycle: 20%). [42] In addition to the broadly explored antitumor use of nanosonosensitizer-enabled SDT in the aforementioned paradigms, it can also be adopted for treating pathogenic bacterial infection, [44][45][46][47] because it can overcome the barriers of traditional antibiotics such as multidrug resistant after continuous and repeated antibiotic administrations. As a proof-of-concept paradigm, a US-sensitive Pd@Pt-T790 nanosonosensitizer was constructed by linking sonosensitizers meso-tetra(4-carboxyphenyl) porphine (T790) with Pd@Pt nanoplates (Figure 4).…”

Section: Sonodynamic Therapymentioning

confidence: 99%

“…In addition to the broadly explored antitumor use of nanosonosensitizer‐enabled SDT in the aforementioned paradigms, it can also be adopted for treating pathogenic bacterial infection, [ 44–47 ] because it can overcome the barriers of traditional antibiotics such as multidrug resistant after continuous and repeated antibiotic administrations. As a proof‐of‐concept paradigm, a US‐sensitive Pd@Pt‐T790 nanosonosensitizer was constructed by linking sonosensitizers meso‐tetra(4‐carboxyphenyl)porphine (T790) with Pd@Pt nanoplates ( Figure ).…”

Section: Sonodynamic Therapymentioning

confidence: 99%

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Emerging Nanomedicine‐Enabled/Enhanced Nanodynamic Therapies beyond Traditional Photodynamics

et al. 2021

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Figure 3. a) Scheme for the constructed Fe(III)/TPPS nanosonosensitizer for synergistic sonotheranostics by RGD-enabled tumor targeting, downregulated SOD2 expression, GSH depletion, Fenton reaction-triggered hydroxyl radicals and SDT. Reproduced with permission. [38] Copyright 2019, Wiley-VCH. b) Schematic illustration of the design principle and mechanism of combinatorial SDT and immunotherapy, including nanosonosensitizer-enabled and SDT-induced antitumor immune responses and checkpoint blockade for tumor immunotherapy. Reproduced under the terms of the CC-BY Creative Commons Attribution 4.

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Section: Sonodynamic Therapymentioning

confidence: 99%

Section: Sonodynamic Therapymentioning

confidence: 99%

Emerging Nanomedicine‐Enabled/Enhanced Nanodynamic Therapies beyond Traditional Photodynamics

et al. 2021

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“…After excluding non-eligible papers, 20 articles had eligibility to be considered for full-text reading. Of these 20 studies, 4 studies were further excluded and in the final stage of screening, 14 studies [11][12][13][14][15][16][17][18][19][20][21][22][23][24] were included in the current systematic review and meta-analysis. The main characteristics of the included studies are described in Table 1.…”

Section: Study Characteristicsmentioning

confidence: 99%

In Vitro Application of Sonodynamic Antimicrobial Chemotherapy as a Sonobactericidal Therapeutic Approach for Bacterial Infections: A Systematic Review and Meta-analysis

Pourhajibagher¹,

Bahador²

2020

J Lasers Med Sci

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Introduction: This study aimed to perform a systematic review of the literature followed by a meta-analysis about the efficacy of sonodynamic antimicrobial chemotherapy (SACT) in bacterial infections. Methods: According to the PICOS (population, intervention, comparison and outcome) recommendations and PRISMA guidelines, an electronic search was conducted in PubMed, SCOPUS, Embase, and Cochrane Library based on the MeSH terms. All analyses were conducted using Biostat's Comprehensive Meta-Analysis version 2.0. The inter-study heterogeneity and publication bias assessments were carried out on the studies using I 2 and the Egger's regression test. Results: Initially, 126 articles were identified in the electronic search, and 14 studies remained after analysis and exclusion of the duplicated studies and eligibility criteria. All results from the included studies displayed a significant reduction of microorganisms. The meta-analysis demonstrated a significant reduction in the bacterial load in all analyses (0.944% [95% CI, 0.901-0.969%; P=0.000]). Also, there was a low risk of bias for microbial load reduction without the evidence of publication bias. Conclusion:The results highlight that there is scientific evidence emphasizing the effectiveness of SACT in reducing the count of microorganisms in bacterial infections.

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“…Most specimens in ND and D control groups showed disordered connective tissue and even supragingival plaque [15,16,11]. In our previous study, HMME-mediated SDT could effectively kill more than 95% of Staphylococcus aureus [14].…”

Section: Histological Analysismentioning

confidence: 99%

“…Recently, many studies have indicated satisfactory results with SDT in inhibiting bacteria such as methicillin-resistant staphylococcus aureus (MRSA) [15], bacillus cereus and escherichia coli [16]. Our previous study showed that HMME-mediated SDT could effectively inhibit the growth of staphylococcus aureus [14].…”

Section: Introductionmentioning

confidence: 99%

In Vivo Assessments of Minocycline combined Hyaluronic Acid-mediated Ultrasound Therapy of Infected Wound in Rats

Zhang

Zhuang

2018

Preprint

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Objectives: The purpose of our research was to examine the effects of Minocycline combined hyaluronic acid (HA)-mediated Ultrasound therapy of infected wound in wister rats .Methods: 40 female wister rats were made wound on the two side of the backbone, then infected in Staphylococcus aureus at the comic for three times. then ,they are divided into four groups: control group, minocycline combined HA alone, ultasound alone , minocycline combined HA-mediated ultasound group ,respective. After 3 times of treatments, the rats were killed and made into specimens.Assessments consisted of visual inspection in the change of the skin, scar formation pathological morphology by hematoxylin and eosin(HE) stain with optical microscopy,IL-1B assaying and TNF-a were performed. Result: Compared with control group, minocycline combined HA alone, ultasound alone, minocycline combined HA-mediated ultasound group all have effect for wound healing, there was a obvious improvement in all parameters over the duration of the experiment(P<0.05). Compared with the control group, minocycline combined HA-mediated ultasound group indicated less inflammation cells (P<0.001) and the reduce of and IL-1B and TNF-a (P<0.001) .Conclusion: Minocycline combined HA-mediated ultrasound can accelerate tissue regrowth ,which exert significant benefits in healing the wounds.

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Sonodynamic action of hypocrellin B on methicillin-resistant Staphylococcus aureus

Cited by 28 publications

References 28 publications

Emerging Nanomedicine‐Enabled/Enhanced Nanodynamic Therapies beyond Traditional Photodynamics

Emerging Nanomedicine‐Enabled/Enhanced Nanodynamic Therapies beyond Traditional Photodynamics

In Vitro Application of Sonodynamic Antimicrobial Chemotherapy as a Sonobactericidal Therapeutic Approach for Bacterial Infections: A Systematic Review and Meta-analysis

In Vivo Assessments of Minocycline combined Hyaluronic Acid-mediated Ultrasound Therapy of Infected Wound in Rats

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