Sonic Hedgehog Is Required for Progenitor Cell Maintenance in Telencephalic Stem Cell Niches

Machold, Robert; Hayashi, Shigemi; Rutlin, Michael; Muzumdar, Mandar Deepak; Nery, Susana Vaz; Corbin, Joshua G.; Gritli-Linde, Amel; Dellovade, Tammy L.; Porter, Jeffery A.; Rubin, Lee L.; Dudek, Henryk; McMahon, Andrew P.; Fishell, Gord

doi:10.1016/s0896-6273(03)00593-2

Cited by 138 publications

(194 citation statements)

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“…During bone development, the IHH pathway plays an important role in chondrocyte proliferation, differentiation, and normal longitudinal bone development (Machold et al 2003;Ingham and McMahon 2001). Hedgehog (HH) activates GLI-mediated transcription through the transmembrane proteins patched (PTCH) and smoothened (SMO).…”

Section: Discussionmentioning

confidence: 99%

(−)-Epigallocatechin-3-gallate induces apoptosis and suppresses proliferation by inhibiting the human Indian Hedgehog pathway in human chondrosarcoma cells

Tang

Yan

Guo

et al. 2010

J Cancer Res Clin Oncol

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Section: Discussionmentioning

confidence: 99%

(−)-Epigallocatechin-3-gallate induces apoptosis and suppresses proliferation by inhibiting the human Indian Hedgehog pathway in human chondrosarcoma cells

Tang

Yan

Guo

et al. 2010

J Cancer Res Clin Oncol

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“…Increasing data now support the notion that developmental signaling pathways remain active in a subset of cells in adult tissues [43][44][45][46][47][48].…”

Section: Hh Signaling In Adult Pancreasmentioning

confidence: 90%

Hedgehog signaling in pancreas development and disease

Lau

Kawahira

Hebrok

2006

Cell. Mol. Life Sci.

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Since its discovery, numerous studies have shown that the Hedgehog (Hh) signaling pathway plays an instrumental role during diverse processes of cell differentiation and organ development. More recently, it has become evident that Hh signaling is not restricted to developmental events, but retains some of its activity during adult life. In mature tissues, Hh signaling has been implicated in the maintenance of stem cell niches in the brain, renewal of the gut epithelium and differentiation of hematopoietic cells. In addition to the basal function in adult tissue, deregulated signaling has been implicated in a variety of cancers, including basal cell carcinoma, glioma and small cell lung cancer. Here, we will focus on the role of Hh signaling in pancreas development and pancreatic diseases, including diabetes mellitus, chronic pancreatitis and pancreatic cancer.

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“…In the dentate gyrus, signaling via secreted Wnt proteins has also been suggested to control neuroblast proliferation and commitment to a neuronal fate (Lie et al 2005). Recent studies have also implicated the Notch and Sonic hedgehog (Shh) pathways in the control of SVZ and/or SGZ cell proliferation and lineage commitment, but the cell-type-specific pattern of expression for components of these pathways has not been fully described (Givogri et al 2006;Androutsellis-Theotokis et al 2006;Palma et al 2005;Machold et al 2003;Ahn and Joyner 2005).…”

Section: External Regulators Of Stem Cell Proliferation and Lineage Cmentioning

confidence: 99%

Cells in the astroglial lineage are neural stem cells

Ihrie¹,

2007

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A common assumption of classical neuroscience was that neurons and glial cells were derived from separate pools of progenitor cells and that, once development was completed, no new neurons were produced. The subsequent disproving of the "no new neuron" dogma suggested that ongoing adult neurogenesis was supported by a population of multipotent neural stem cells. Two germinal regions within the adult mammalian brain were shown to contain neural progenitor cells: the subventricular zone (SVZ) along the walls of the lateral ventricles, and the subgranular zone (SGZ) within the dentate gyrus of the hippocampus. Surprisingly, when the primary progenitors (stem cells) of the new neurons in these regions were identified, they exhibited structural and biological markers of astrocytes. The architecture of these germinal regions and the pattern of division of neural stem cells have raised fundamental questions about the mechanism of adult neurogenesis. This review describes studies on the origin of adult neural stem cells, the features distinguishing them from astrocytes in non-germinal regions, and the control mechanisms of the proliferation and differentiation of these cells. Astrocytic adult neural stem cells are part of a developmental lineage extending from the neuroepithelium to radial glia to germinal astrocytes. Adult neural stem cells appear to be strongly influenced by their local microenvironment, while also contributing significantly to the architecture of these germinal zones. However, environment alone does not seem to be sufficient to induce non-germinal astrocytes to behave as neural stem cells. Although emerging evidence suggests that significant heterogeneity exists within populations of germinal zone astrocytes, the way that these differences are encoded remains unclear. The further characterization of these cells should eventually provide a body of knowledge central to the understanding of brain development and disease.

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Sonic Hedgehog Is Required for Progenitor Cell Maintenance in Telencephalic Stem Cell Niches

Cited by 138 publications

References 0 publications

(−)-Epigallocatechin-3-gallate induces apoptosis and suppresses proliferation by inhibiting the human Indian Hedgehog pathway in human chondrosarcoma cells

(−)-Epigallocatechin-3-gallate induces apoptosis and suppresses proliferation by inhibiting the human Indian Hedgehog pathway in human chondrosarcoma cells

Hedgehog signaling in pancreas development and disease

Cells in the astroglial lineage are neural stem cells

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