(−)-Epigallocatechin-3-gallate induces apoptosis and suppresses proliferation by inhibiting the human Indian Hedgehog pathway in human chondrosarcoma cells

Tang, Guiqian; Yan, Taiqiang; Guo, Wei; Ren, Tingting; Peng, Changliang; Zhao, Hui; Lu, Xin; Zhao, Fulong; Han, Xiaoguang

doi:10.1007/s00432-010-0765-3

Cited by 44 publications

(28 citation statements)

References 26 publications

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“…We found that the percentage of EGCG-treated cells in the sub-G 1 phase which may comprise of apoptotic cells was significantly increased as compared to the untreated cells after 24 and 48 h treatment with EGCG ( Figure 5), suggesting a up-regulation of cell death machinery. This is in agreement with previous studies which established that apoptosis is the likely mechanism of action of green tea polyphenol, EGCG for inhibiting cell growth in various carcinomas (Yang et al, 1998;Gupta et al, 2003;Huh et al, 2004;Qanungo et al, 2005;Khan et al, 2006;Gu et al, 2009;Tang et al, 2010). It has also been shown that treatment of MCF7 breast cancer cells with EGCG resulted in G 0 /G 1 phase cell cycle arrest (Liang et al, 1999).…”

Section: Failure Of Conventional Treatment Strategies Insupporting

confidence: 82%

(-)-Epigallocatechin-3-Gallate Induces Apoptosis and Inhibits Invasion and Migration of Human Cervical Cancer Cells

Sharma¹,

Nusri²,

Begum³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Section: Failure Of Conventional Treatment Strategies Insupporting

confidence: 82%

(-)-Epigallocatechin-3-Gallate Induces Apoptosis and Inhibits Invasion and Migration of Human Cervical Cancer Cells

Sharma¹,

Nusri²,

Begum³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Taken together, these results indicate that the Hedgehog signaling could be a target of EGCG, leading to the inhibition of prostate cancer cell growth in vitro and in vivo. Finally, EGCG has also been shown to effectively inhibit cellular proliferation and induce apoptosis of SW1353 and CRL-7891 human chondrosarcoma cells by targeting the Indian Hedgehog pathway, suggesting that EGCG can have therapeutic relevance in the treatment of patients with chondrosarcoma (138). Yet the molecular mechanisms of inhibition of carcinogenesis in animals and humans remain to be further investigated.…”

Section: Natural Products and Human Healthmentioning

confidence: 96%

Chemoprevention in Gastrointestinal Physiology and Disease. Natural products and microbiome

Greiner

Papineni

Umar

2014

American Journal of Physiology-Gastrointestinal and Liver Physi

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The human intestinal tract harbors a complex ecosystem of commensal bacteria that play a fundamental role in the well-being of their host. There is a general consensus that diet rich in plant-based foods has many advantages in relation to the health and well-being of an individual. In adults, diets that have a high proportion of fruit and vegetables and a low consumption of meat are associated with a highly diverse microbiota and are defined by a greater abundance of Prevotella compared with Bacteroides, whereas the reverse is associated with a diet that contains a low proportion of plant-based foods. In a philosophical term, our consumption of processed foods, widespread use of antibiotics and disinfectants, and our modern lifestyle may have forever altered our ancient gut microbiome. We may never be able to identify or restore our microbiomes to their ancestral state, but dietary modulation to manipulate specific gut microbial species or groups of species may offer new therapeutic approaches to conditions that are prevalent in modern society, such as functional gastrointestinal disorders, obesity, and age-related nutritional deficiency. We believe that this will become an increasingly important area of health research.

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“…In medulloblastoma cells, CUR was able to arrest cells at the G2/M phase of the cell cycle and induce apoptosis by down-regulating the expression of the sonic hedgehog homolog (SHH) protein and its downstream molecules GLI1 and protein patched homolog 1 (PTCH1) [68]. A recent study by Tang et al showed that EGCG affected proliferation and promoted apoptosis of SW1353 and CRL-7891 human chondrosarcoma cells in a dose-dependent manner by inhibiting PTCH1 and GLI protein expression [69]. …”

Section: Polyphenols Target Signal Transduction Pathways Involved mentioning

confidence: 99%

In Vitro and in Vivo Antitumoral Effects of Combinations of Polyphenols, or Polyphenols and Anticancer Drugs: Perspectives on Cancer Treatment

Fantini

Benvenuto

Masuelli

et al. 2015

IJMS

275

236

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Carcinogenesis is a multistep process triggered by genetic alterations that activate different signal transduction pathways and cause the progressive transformation of a normal cell into a cancer cell. Polyphenols, compounds ubiquitously expressed in plants, have anti-inflammatory, antimicrobial, antiviral, anticancer, and immunomodulatory properties, all of which are beneficial to human health. Due to their ability to modulate the activity of multiple targets involved in carcinogenesis through direct interaction or modulation of gene expression, polyphenols can be employed to inhibit the growth of cancer cells. However, the main problem related to the use of polyphenols as anticancer agents is their poor bioavailability, which might hinder the in vivo effects of the single compound. In fact, polyphenols have a poor absorption and biodistribution, but also a fast metabolism and excretion in the human body. The poor bioavailability of a polyphenol will affect the effective dose delivered to cancer cells. One way to counteract this drawback could be combination treatment with different polyphenols or with polyphenols and other anti-cancer drugs, which can lead to more effective antitumor effects than treatment using only one of the compounds. This report reviews current knowledge on the anticancer effects of combinations of polyphenols or polyphenols and anticancer drugs, with a focus on their ability to modulate multiple signaling transduction pathways involved in cancer.

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(−)-Epigallocatechin-3-gallate induces apoptosis and suppresses proliferation by inhibiting the human Indian Hedgehog pathway in human chondrosarcoma cells

Abstract: Our findings demonstrate that EGCG is effective for growth inhibition of a chondrosarcoma cell lines in vitro, and suggest that EGCG may be a new therapeutic option for patients with chondrosarcoma.

Cited by 44 publications

References 26 publications

(-)-Epigallocatechin-3-Gallate Induces Apoptosis and Inhibits Invasion and Migration of Human Cervical Cancer Cells

(-)-Epigallocatechin-3-Gallate Induces Apoptosis and Inhibits Invasion and Migration of Human Cervical Cancer Cells

Chemoprevention in Gastrointestinal Physiology and Disease. Natural products and microbiome

In Vitro and in Vivo Antitumoral Effects of Combinations of Polyphenols, or Polyphenols and Anticancer Drugs: Perspectives on Cancer Treatment

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