Sonic Hedgehog–dependent proliferation in a series of patients with colorectal cancer

Douard, Richard; Moutereau, Stéphane; Pernet, Pascal; Chimingqi, Mihelaiti; Allory, Yves; Manivet, Philippe; Conti, Marc; Vaubourdolle, Michel; Cugnenc, Paul-Henri; Loric, Sylvain

doi:10.1016/j.surg.2005.10.012

Cited by 119 publications

(109 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similarly, when he studied HT-29 colorectal cell line, exogenous SHH promoted cell proliferation, while inhibition of SHH expression decreased proliferation. Expression of GLI1 mRNA increased with exogenous exposure to SHH (Douard et al, 2006).…”

Section: Discussionmentioning

confidence: 92%

“…The data about the roles they play on CRC have not been well documented. Some of them even remained controversial (Berman et al, 2003;Douard et al, 2006;Monzo et al, 2006;Chatel et al, 2007;Varnat et al, 2009; 2320 Yoshikawa et al, 2009;Fu et al, 2010;Saqui-Salces and Merchant, 2010;You et al, 2010;Tapati et al, 2011). There were disagreements in the roles of downstream Hh signaling components i.e.…”

Section: Expression and Clinical Significance Of Hedgehog Signaling Pmentioning

confidence: 99%

See 1 more Smart Citation

Expression and Clinical Significance of Hedgehog Signaling Pathway Related Components in Colorectal Cancer

Wang

Li²,

Wu³

et al. 2012

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Aim: To investigate the expression of three components of the Hedgehog (Hh) signaling pathway (SHH, SMO and GLI1) in human colorectal cancer (CRC) tissues and evaluate their association with clinicopathologic characteristics of the patients. Methods: Fresh tumor tissues and matched tissues adjacent to the tumor were collected from 43 CRC patients undergoing surgery. Normal colorectal tissues from 20 non-CRC cases were also sampled as normal controls. The expression of SHH, SMO, GLI1 mRNAs was assessed by RT-PCR and proteins were detected by immunohistochemical staining. Associations with clinicopathological characteristics of patients were analyzed. Results: SHH mRNA was expressed more frequently in tumor tissues than in normal tissues, but the difference did not reach significance in comparison to that in the adjacent tissues. SMO and GLI1 mRNAs were expressed more frequently in tumor tissues than in both adjacent andnormal tissues. The expression intensities of SHH, SMO, GLI1 mRNA in tumor tissues were significantly higher than those in adjacent tissues and normal tissues. Proteins were also detected more frequently in tumors than other tissues. No significant links were apparent with gender, age, location, degree of infiltration or Dukes stage. Conclusion: Positive rates and intensities of mRNA and protein expression of Hh signaling pathway related genes SHH, SMO, GLI1 were found to be significantly increased in CRC tissues. However, over-expression did not appear to be associated with particular clinicopathological characteristics.

show abstract

Section: Discussionmentioning

confidence: 92%

Section: Expression and Clinical Significance Of Hedgehog Signaling Pmentioning

confidence: 99%

Expression and Clinical Significance of Hedgehog Signaling Pathway Related Components in Colorectal Cancer

Wang

Li²,

Wu³

et al. 2012

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…FoxM1 has been shown to activate the oncogenic pathways that are important in carcinogenesis such as mitogen activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK), phosphatdyl inositol 3-kinase (PI3k)/Akt), nuclear factor kappa-B and sonic hedgehog (SHH) [33][34][35][36][37]. Moreover, FoxM1 has been shown to decrease the gene expression levels of the tumor suppressor genes and also the genes involved in cellular senescence like p53 and p21 cip1 [20,38].…”

Section: Discussionmentioning

confidence: 99%

Targeting FoxM1 transcription factor in T-cell acute lymphoblastic leukemia cell line

et al. 2015

View full text Add to dashboard Cite

The Forkhead box protein M1 (FoxM1) is an important transcription factor having significant roles in various cellular events. FoxM1 overexpression has been reported to be related with many types of cancer. However, it is not known whether it contributes to oncogenesis of acute lymphoblastic leukemia. Siomycin A, a thiazol antibiotic, is known to inhibit FoxM1 transcriptional activity. In this study, we aimed to determine gene expression levels of FoxM1 in Jurkat cells (T-cell acute lymphoblastic leukemia cell line) and therapeutic potential of targeting FoxM1 by siomycin A alone and in combination with dexamethasone which improves the survival of children with T-cell acute lymphoblastic leukemia (ALL). We also examined the molecular mechanisms of siomycin A and dexamethasone-induced cell death in Jurkat cells. We demonstrated that FoxM1 mRNA is highly expressed in Jurkat cells. Dexamethasone and siomycin A caused a significant reduction in gene expression levels of FoxM1 in Jurkat cells. Targeting FoxM1 by siomycin A and dexamethasone caused a significant decrease in T-ALL cell line proliferation through induction of G1 cell cycle arrest. All these findings suggest a possible role of FoxM1 in T-cell ALL pathogenesis and represent FoxM1 as an attractive target for T-cell ALL therapy. © 2014 Elsevier Ltd.Dokuz Eylul University Scientific Research Projects Coordination Unit (99.3456.23

show abstract

“…Human cancer types frequently harboring a deregulation in the Hh pathway include leukemia, multiple myeloma, and brain, skin, head and neck, lung, liver, gastrointestinal, colorectal, pancreatic, prostate, mammary, ovarian, and renal carcinomas (Berman et al, 2003;Thayer et al, 2003;Karhadkar et al, 2004;Oniscu et al, 2004;Sanchez et al, 2004;Sheng et al, 2004;Ohta et al, 2005;Datta and Datta, 2006;Douard et al, 2006;Mimeault et al, 2006Mimeault et al, , 2007aBian et al, 2007;Chen et al, 2007b;Stecca et al, 2007;Taniguchi et al, 2007;Bhattacharya et al, 2008;Hegde et al, 2008;Tada et al, 2008;Eichenmü ller et al, 2009). More importantly, accumulating lines of evidence have also revealed that the persistent activation of the Hh cascade may represent a critical step in the malignant transformation of cancer stem/progenitor cells (also designated as cancer-and metastasis-initiating cells), treatment resistance, and disease relapse Bar et al, 2007;Clement et al, 2007;Ehtesham et al, 2007;Mimeault et al, 2007bPeacock et al, 2007;Batra, 2008a, 2010b,c;Xu et al, 2008;Kobune et al, 2009;Ward et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Frequent Deregulations in the Hedgehog Signaling Network and Cross-Talks with the Epidermal Growth Factor Receptor Pathway Involved in Cancer Progression and Targeted Therapies

2010

View full text Add to dashboard Cite

Sonic Hedgehog–dependent proliferation in a series of patients with colorectal cancer

Cited by 119 publications

References 15 publications

Expression and Clinical Significance of Hedgehog Signaling Pathway Related Components in Colorectal Cancer

Expression and Clinical Significance of Hedgehog Signaling Pathway Related Components in Colorectal Cancer

Targeting FoxM1 transcription factor in T-cell acute lymphoblastic leukemia cell line

Frequent Deregulations in the Hedgehog Signaling Network and Cross-Talks with the Epidermal Growth Factor Receptor Pathway Involved in Cancer Progression and Targeted Therapies

Contact Info

Product

Resources

About